2. Gene
  3. TFAP4 - transcription factor AP-4 Gene

TFAP4 - transcription factor AP-4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录因子 AP-4

种属: Homo sapiens

同用名: AP-4; bHLHc41

基因 ID: 7023 | 基因类型: protein coding

关于 TFAP4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,257,186-4,273,023 (from NCBI)

This gene has 7 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues.

功能概要

基本螺旋-环-螺旋-拉链 (bHLH-ZIP) 家族的转录因子包含一个用于 DNA 结合的基本结构域，以及用于寡聚化的 HLH 和 ZIP 结构域。转录因子 AP4 通过结合对称 DNA 序列 CAGCTG 来激活病毒和细胞基因 (Mermod 等人，1988 [PubMed 2833704]；Hu 等人，1990 [PubMed 2123466]) 。[OMIM 提供，2009 年 7 月]

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

TFAP4 基因产物(1)

mRNA Protein Name
NM_003223.3 NP_003214.1 transcription factor AP-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9931457 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
2833704 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
2833704 GOA
enables E-box binding IDA
IDA: 通过直接分析推断
7933101 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16540471 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16924111 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
2123466 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
2123466 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
2833704 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
IDA: 通过直接分析推断
18818310 GOA
involved in negative regulation by host of viral transcription IDA
IDA: 通过直接分析推断
14645924 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
7933101 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9931457 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18818310 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18818310 GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18818310 GOA
involved in positive regulation by host of viral transcription IDA
IDA: 通过直接分析推断
2833704 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12663744 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
18818310 GOA
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
19505873 GOA
involved in regulation of mitotic cell cycle phase transition IDA
IDA: 通过直接分析推断
18818310 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
7933101 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFAP4 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (49 - 100)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
蛋白主名 其他名称

transcription factor AP-4

activating enhancer-binding protein 4

TFAP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TFAP4 Q01664 PTPN3 Homo sapiens P26045
Y2H Array
32296183
Intra TFAP4 Q01664 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0
Validated Y2H
32296183
Intra TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0
Y2H Array
32296183
Intra TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra TFAP4 Q01664 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra TFAP4 Q01664 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra TFAP4 Q01664 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra TFAP4 Q01664 VMAC Homo sapiens Q2NL98
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 VMAC Homo sapiens Q2NL98
Validated Y2H
32296183
Intra TFAP4 Q01664 VMAC Homo sapiens Q2NL98
Y2H Array
32296183
Intra TFAP4 Q01664 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra TFAP4 Q01664 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra TFAP4 Q01664 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra TFAP4 Q01664 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
32296183
Intra TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26
Y2H Array
25416956
Intra TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra TFAP4 Q01664 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra TFAP4 Q01664 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra TFAP4 Q01664 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra TFAP4 Q01664 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra TFAP4 Q01664 GEM Homo sapiens P55040
Anti Bait CoIP
16924111
Intra TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
Intra TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24
Y2H Array
32296183
Intra TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
32296183
Intra TFAP4 Q01664 AJUBA Homo sapiens Q96IF1
Y2H Array
32296183
Intra TFAP4 Q01664 AJUBA Homo sapiens Q96IF1
Validated Y2H
32296183
Intra TFAP4 Q01664 AJUBA Homo sapiens Q96IF1
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14412 TFAP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TFAP4 MGD MGI:103239
Bos taurus TFAP4 VGNC VGNC:35781
Rattus norvegicus TFAP4 RGD RGD:1308357
Felis catus TFAP4 VGNC VGNC:107823
Macaca mulatta TFAP4 VGNC VGNC:104759
Canis familiaris TFAP4 VGNC VGNC:47287
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