2. Gene
  3. KIFAP3 - kinesin associated protein 3 Gene

KIFAP3 - kinesin associated protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白相关蛋白 3

种属: Homo sapiens

同用名: FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1

基因 ID: 22920 | 基因类型: protein coding

关于 KIFAP3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,921,329-170,085,184 (from NCBI)

This gene has 6 transcripts (splice variants) and 260 orthologues. Broad expression in brain (RPKM 27.3), testis (RPKM 15.2) and 24 other tissues.

功能概要

小 G 蛋白 GDP 解离刺激物 (smg GDS) 是一种调节蛋白，对一组小 G 蛋白具有两种活性，包括 Rho 和 Rap1 家族成员以及 Ki-Ras；一种是刺激它们的 GDP/GTP 交换反应，另一种是抑制它们与细胞膜的相互作用。该基因编码的蛋白质包含 9 个“犰狳”重复序列，并通过这些重复序列与 smg GDS 蛋白质相互作用。这种高度集中在内质网周围的蛋白质被 v-src 磷酸化，这种磷酸化降低了蛋白质对 smg GDS 的亲和力。据认为，这种蛋白质充当人类染色体相关多肽 (HCAP) 和细胞核中的驱动蛋白超家族蛋白 KIF3A/B 之间的连接子，并且它在染色体与 ATP 酶马达蛋白的相互作用中发挥作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2011 年 3 月]

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a Kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

KIFAP3 基因产物(6)

mRNA Protein Name
NM_001204514.2 NP_001191443.1 kinesin-associated protein 3 isoform 2
NM_001204516.2 NP_001191445.1 kinesin-associated protein 3 isoform 3
NM_001204517.2 NP_001191446.1 kinesin-associated protein 3 isoform 4
NM_001375830.1 NP_001362759.1 kinesin-associated protein 3 isoform 5
NM_001375831.1 NP_001362760.1 kinesin-associated protein 3 isoform 6
NM_014970.4 NP_055785.2 kinesin-associated protein 3 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinesin binding IPI
IPI: 通过物理相互作用推断
16298999 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9506951 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
24338362 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
16298999 GOA
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
16298999 GOA
part of kinesin II complex IDA
IDA: 通过直接分析推断
16298999 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
16298999 GOA
colocalizes with spindle microtubule IDA
IDA: 通过直接分析推断
16298999 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIFAP3 蛋白结构

KAP

KAP: Kinesin-associated protein (KAP) (13 - 720)

  • 0
  • 200
  • 400
  • 600
  • 792 a.a.
蛋白主名 其他名称

kinesin-associated protein 3

small G protein GDP dissociation stimulator

KIFAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KIFAP3 Q92845 KIF3A Homo sapiens Q9Y496
Anti Bait CoIP
16298999
Intra KIFAP3 Q92845 KIF3A Homo sapiens Q9Y496
Anti Tag CoIP
33961781
Intra KIFAP3 Q92845 KIF3A Homo sapiens Q9Y496
TAP
27173435
Intra KIFAP3 Q92845 KIF3A Homo sapiens Q9Y496
Anti Tag CoIP
26496610
Intra KIFAP3 Q92845 KIF3A Homo sapiens Q9Y496
Anti Tag CoIP
28514442
Intra KIFAP3 Q92845 C19orf44 Homo sapiens Q9H6X5-2
Validated Y2H
32296183
Intra KIFAP3 Q92845 NAA11 Homo sapiens Q9BSU3
Validated Y2H
32296183
Intra KIFAP3 Q92845 KIF3B Homo sapiens O15066
Anti Tag CoIP
33961781
Intra KIFAP3 Q92845 KIF3B Homo sapiens O15066
Anti Bait CoIP
16298999
Intra KIFAP3 Q92845 KIF3B Homo sapiens O15066
TAP
27173435
Intra KIFAP3 Q92845 KIF3B Homo sapiens O15066
Anti Tag CoIP
28514442
Intra KIFAP3 Q92845 KIF3B Homo sapiens O15066
Anti Tag CoIP
26496610
Intra KIFAP3 Q92845 NCF2 Homo sapiens P19878
Y2H Array
31515488
Intra KIFAP3 Q92845 NAA10 Homo sapiens P41227
Validated Y2H
25416956
Intra KIFAP3 Q92845 NAA10 Homo sapiens P41227
Y2H Array
25416956
Intra KIFAP3 Q92845 NAA10 Homo sapiens P41227
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Lipoma

Lipoma Of Breast
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy

Jeune Syndrome

Asphyxiating Thoracic Dysplasia

Short-Rib Thoracic Dysplasia With Or Without Polydactyly

Thoracic Pelvic Phalangeal Dystrophy

Asphyxiating Thoracic Chondrodystrophy

Atd

Chondroectodermal Dysplasia-Like Syndrome

Infantile Thoracic Dystrophy

Jeune Thoracic Dysplasia

Thoracic Asphyxiant Dystrophy

Thoracic-Pelvic-Phalangeal Dystrophy

Short-Rib Thoracic Dysplasia Without Polydactyly

Asphyxiating Thoracic Dystrophy Of The Newborn

Asphyxiating Thorax Dystrophy
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07297 KIFAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KIFAP3 MGD MGI:107566
Canis familiaris KIFAP3 VGNC VGNC:42413
Felis catus KIFAP3 VGNC VGNC:63120
Rattus norvegicus KIFAP3 RGD RGD:1305191
Macaca mulatta KIFAP3 VGNC VGNC:73842
Bos taurus KIFAP3 VGNC VGNC:30610
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