WBP11 - WW domain binding protein 11 Gene

中文名称：WW 结构域结合蛋白 11

种属: Homo sapiens

同用名: BUG13; FAP90; NPWBP; SIPP1; VCTRL; CFAP90; VCTERL; WBP-11; PPP1R165

基因 ID: 51729 | 基因类型: protein coding

关于 WBP11

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:14,784,582-14,803,478 (from NCBI)

This gene has 5 transcripts (splice variants), 17 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 48.6), bone marrow (RPKM 38.2) and 25 other tissues.

功能概要

该基因编码一种核蛋白，它与 mRNA 剪接因子和含有中间丝的核周网络共定位。该蛋白与小鼠 Wbp11 蛋白具有 95% 的氨基酸序列同一性。它包含两个富含脯氨酸的区域，与核蛋白 Npw38 的 WW 结构域结合，因此该蛋白也称为 Npw38 结合蛋白 NpwBP。 Npw38-NpwBP 复合体可能作为细胞核中 mRNA 工厂的一个组成部分发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

WBP11 基因产物(1)

mRNA	Protein	Name
NM_016312.3	NP_057396.1	WW domain-binding protein 11

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables WW domain binding	IPI IPI: 通过物理相互作用推断	19592703	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16000308	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WBP11 蛋白结构

Wbp11

0
100
200
300
400
500
600
641 a.a.

蛋白主名

其他名称

WW domain-binding protein 11

Npw38-binding protein NpwBP

WBP11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	WBP11	Q9Y2W2	MCRS1	Homo sapiens	Q96EZ8	MAPPIT	32296183
Intra	WBP11	Q9Y2W2	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	WBP11	Q9Y2W2	PPP1CA	Homo sapiens	P62136	Y2H	22365833
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	FYN	Homo sapiens	P06241	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	FYN	Homo sapiens	P06241	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	MAPPIT	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	Anti Tag CoIP	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	Anti Tag CoIP	33961781
Intra	WBP11	Q9Y2W2	TESC	Homo sapiens	Q96BS2	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Anti Tag CoIP	33961781
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Anti Tag CoIP	28514442
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Y2H Pooling	16189514
Intra	WBP11	Q9Y2W2	CD2BP2	Homo sapiens	O95400	Y2H	16000308
Intra	WBP11	Q9Y2W2	CD2BP2	Homo sapiens	O95400	Protein Array	16000308
Cross	WBP11	Q9Y2W2	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects

VCTERL	Vcterl Syndrome
VCTRL

Baastrup'S Syndrome

Kissing Spine	Baastrup Syndrome
Kissing Spine, Site Unspecified	Osteoarthrosis Interspinalis
Overriding Of Dorsal Spinous Processes	Localised Idiopathic Skeletal Hyperostosis
Baastrup Disease

Renpenning Syndrome 1

Renpenning Syndrome	Golabi-Ito-Hall Syndrome
Mrxs3	Mrxs8
X-Linked Intellectual Disability Due To Pqbp1 Mutations	RENS1
Sutherland-Haan X-Linked Mental Retardation Syndrome	Shs
Mrx55	X-Linked Intellectual Disability, Renpenning Type
Sutherland-Haan Syndrome	Mental Retardation, X-Linked, Renpenning Type
Mental Retardation, X-Linked, With Spastic Diplegia	Mental Retardation, X-Linked, Syndromic 3
Mental Retardation, X-Linked, Syndromic 8	Mental Retardation, X-Linked 55
Syndromic X-Linked Mental Retardation 8	X-Linked Mental Retardation Renpenning Type
X-Linked Mental Retardation With Spastic Diplegia	Sutherland-Haan X-Linked Intellectual Disability Syndrome
X-Linked Intellectual Disability With Spastic Diplegia	Hamel Cerebropalatocardiac Syndrome
Porteous Syndrome	X-Linked Intellectual Deficit Due To Pqbp1 Mutations
X-Linked Intellectual Deficit, Renpenning Type	X-Linked Intellectual Disability, Sutherland-Haan Type
Hamel Cerebro-Palato-Cardiac Syndrome	Renpenning Syndrome, Type 1

Olmsted Syndrome, X-Linked

OLMSX	Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked
Ppkmx	X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
X-Linked Olmsted Syndrome	Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome	Abdominal Obesity Metabolic Syndrome
Metabolic Syndrome X	Aoms2
Aoms1

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2	FANCD2
Fad2	Fa4
Fancd	Fanconi Pancytopenia Type 4
Fanconi Anemia, Complementation Group D	Fanconi Pancytopenia, Type 4
Facd	Fanconi Anemia Complementation Group D

Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15749	WBP11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	WBP11	VGNC	VGNC:99700
Canis familiaris	WBP11	VGNC	VGNC:48339
Rattus norvegicus	WBP11	RGD	RGD:1307911
Mus musculus	WBP11	MGD	MGI:1891823

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