SLC52A1 - solute carrier family 52 member 1 Gene

中文名称：溶质载体家族 52 成员 1

种属: Homo sapiens

同用名: PAR2; RFT1; RBFVD; RFVT1; hRFT1; GPCR42; GPR172B; huPAR-2

基因 ID: 55065 | 基因类型: protein coding

关于 SLC52A1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,032,602-5,042,414 (from NCBI)

This gene has 5 transcripts (splice variants), 175 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 20.9), placenta (RPKM 16.1) and 2 other tissues.

功能概要

生物氧化还原反应需要电子供体和受体。维生素 B2 是黄素腺嘌呤二核苷酸 (FAD) 和黄素单核苷酸 (FMN) 中黄素的来源，它们是常见的氧化还原试剂。该基因编码核黄素 (维生素 B2) 转运蛋白家族的成员。这种蛋白质的单倍体不足会导致母体核黄素缺乏。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2013 年 1 月]

Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

SLC52A1 基因产物(2)

mRNA	Protein	Name
NM_001104577.2	NP_001098047.1	solute carrier family 52, riboflavin transporter, member 1 precursor
NM_017986.4	NP_060456.3	solute carrier family 52, riboflavin transporter, member 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables riboflavin transmembrane transporter activity	IDA IDA: 通过直接分析推断	20463145	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in riboflavin transport	IDA IDA: 通过直接分析推断	20463145	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	20463145	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC52A1 蛋白结构

DUF1011

0
100
200
300
400
448 a.a.

蛋白主名

其他名称

solute carrier family 52, riboflavin transporter, member 1

G protein-coupled receptor 172B

SLC52A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC52A1	Q9NWF4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	SGCB	Homo sapiens	Q16585	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	SGCB	Homo sapiens	Q16585	Y2H Array	32296183
Intra	SLC52A1	Q9NWF4	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC52A1	Q9NWF4	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Riboflavin Deficiency

Ariboflavinosis	Maternal Riboflavin Deficiency
RBFVD	Vitamin B2 Deficiency
Hyporiboflavinosis

Brown-Vialetto-Van Laere Syndrome

Fazio-Londe Disease

Fazio-Londe Syndrome	Riboflavin Transporter Deficiency Neuronopathy
Brown-Vialetto-Van Laere Syndrome	Progressive Bulbar Palsy Of Childhood
Bulbar Palsy, Progressive, Of Childhood	Bvvls
Pontobulbar Palsy With Deafness	Progressive Bulbar Palsy With Sensorineural Deafness
Riboflavin Transporter Deficiency	FALOND
Bulbar Palsy Progressive Of Childhood	Bulbar Palsy Of Childhood, Progressive

Progressive Bulbar Palsy

Bulbar Palsy, Progressive	Progressive Bulbar Atrophy
Bulbar Palsy	Pbp - [Progressive Bulbar Palsy]
Progressive Bulbar Paralysis	Bulbar Paralysis
Chronic Bulbar Palsy	Chronic Bulbar Paralysis
Supranuclear Bulbar Paralysis

Brown-Vialetto-Van Laere Syndrome 2

BVVLS2	Rfvt3-Related Riboflavin Transporter Deficiency
Rtd3	Riboflavin Transporter Deficiency 3
Brown-Vialetto-Van Laere Syndrome, Type 2

Multiple Acyl-Coa Dehydrogenase Deficiency

MADD	Ethylmalonic-Adipicaciduria
Ema	Glutaric Acidemia Iia
Glutaric Acidemia Iib	Ga Ii
Glutaric Acidemia Iic	Glutaric Acidemia Type 2
Glutaric Acidemia Ii	Glutaric Aciduria Ii
Electron Transfer Flavoprotein Deficiency	Glutaric Aciduria Type 2
Mad Deficiency	Glutaric Acidemia Type Ii
Glutaric Aciduria 2	Etfa Deficiency
Etfb Deficiency	Etfdh Deficiency
Multiple Acyl Coenzyme A Dehydrogenase Deficiency	Ga2
Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency	Electron Transfer Flavoprotein Dehydrogenase Deficiency
Ga 2	Glutaric Acidemia 2
Glutaric Acidemia, Type 2	Glutaric Aciduria, Type 2
Mad	Multiple Fad Dehydrogenase Deficiency
Ethylmalonic Adipic Aciduria	Glutaricaciduria Ii
Glutaric Aciduria 2a	GA2A
Gaiia	Glutaricaciduria Iia
Glutaric Aciduria 2b	GA2B
Gaiib	Glutaricaciduria Iib
Glutaric Aciduria 2c	GA2C
Gaiic	Glutaricaciduria Iic
Glutaricaciduria, Type Iia	Glutaric Acidemia Type 2a
Glutaric Acidemia Type 2c	Glutaric Aciduria Iia
Glutaric Aciduria Iib	Glutaric Aciduria Iic

Schwannoma Of Twelfth Cranial Nerve

Hypoglossal Schwannoma

Schwannoma Of The Twelfth Cranial Nerve

Hypoglossal Nerve Disease

Hypoglossal Nerve Diseases	Disorder Of 12th Nerve
Disorder Of Hypoglossal [12th] Nerve	Disorder Of Hypoglossal Nerve
Disorder Of Xii Nerve	Disorders Of The Twelfth Cranial Nerve
Disorders Of 12th Cranial Nerve

Angular Cheilitis

Cheilosis	Angular Cheilosis
Angular Stomatitis	Commissural Cheilitis

Primary Optic Atrophy

Mitochondrial Complex I Deficiency, Nuclear Type 20

Acyl-Coa Dehydrogenase 9 Deficiency	Acad9 Deficiency
MC1DN20	Mitochondrial Complex I Deficiency Due To Acad9 Deficiency
Nuclear Type Mitochondrial Complex I Deficiency 20	Acyl-Coa Dehydrogenase Family, Member 9, Deficiency Of
Mitochondrial Complex 1 Deficiency Due To Acad9 Deficiency	Deficiency Of Acyl-Coa Dehydrogenase Family Member 9
Acyl-Coa Dehydrogenase Family, Member 9, Deficiency

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of

Vlcad Deficiency	Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency	Lcad Deficiency
Very Long-Chain Acyl-Coa Dehydrogenase Deficiency	Long Chain Acyl-Coa Dehydrogenase Deficiency
ACADVLD	Acadl Deficiency
Vlcadd	Long-Chain Acyl-Coa Dehydrogenase Deficiency
Acadvl	Acyl-Coa Dehydrogenase Very Long Chain Deficiency
Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency	Vlcad-C
Vlcad-H	Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of
Acyl-Coa Dehydrogenase Very Long-Chain Deficiency	Acyl-Coa Dehydrogenase Long-Chain Deficiency
Deficiency, Very Long Chain Acyl-Coa Dehydrogenase	Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency

Cranial Nerve Palsy

Cranial Nerve Paralysis	Cranial Nerve Diseases
Cranial Nerve Palsies

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13277	SLC52A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC52A1	MGD	MGI:1289288
Macaca mulatta	SLC52A1	VGNC	VGNC:77795
Others	SLC52A1	NCBI

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