SYVN1 - synoviolin 1 Gene

中文名称：滑膜增生素 1

种属: Homo sapiens

同用名: DER3; HRD1

基因 ID: 84447 | 基因类型: protein coding

关于 SYVN1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,127,279-65,134,519 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 27.2), appendix (RPKM 21.7) and 25 other tissues.

功能概要

该基因编码一种参与内质网 (ER) 相关降解的蛋白质。编码的蛋白质通过从 ER 逆行转运到胞质溶胶，去除 ER 应激期间积累的未折叠蛋白质。这种蛋白质还使用泛素-蛋白酶体系统进一步降解未折叠的蛋白质。序列分析确定了编码不同异构体的两个转录本变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

SYVN1 基因产物(2)

mRNA	Protein	Name
NM_032431.3	NP_115807.1	E3 ubiquitin-protein ligase synoviolin isoform a
NM_172230.3	NP_757385.1	E3 ubiquitin-protein ligase synoviolin isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	16186510	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17170702	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	21636303	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	12459480	GOA
enables ubiquitin protein ligase activity	IMP IMP: 通过突变表型推断	21245296	GOA
enables ubiquitin-specific protease binding	IPI IPI: 通过物理相互作用推断	22590560	GOA
enables unfolded protein binding	IPI IPI: 通过物理相互作用推断	17059562	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IDA IDA: 通过直接分析推断	12459480	GOA
acts upstream of or within ERAD pathway	IMP IMP: 通过突变表型推断	21245296	GOA
involved in ERAD pathway	IMP IMP: 通过突变表型推断	22607976	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	12459480	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	14593114	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	21454652	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	12459480	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: 通过突变表型推断	25660456	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	14593114	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Derlin-1 retrotranslocation complex	IDA IDA: 通过直接分析推断	21454652	GOA
part of Hrd1p ubiquitin ligase ERAD-L complex	IDA IDA: 通过直接分析推断	28827405	GOA
part of Hrd1p ubiquitin ligase ERAD-L complex	IMP IMP: 通过突变表型推断	26471130	GOA
is active in endoplasmic reticulum	IDA IDA: 通过直接分析推断	37795761	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	12459480	GOA
located in endoplasmic reticulum quality control compartment	IDA IDA: 通过直接分析推断	23233672	GOA
located in smooth endoplasmic reticulum	IDA IDA: 通过直接分析推断	16186510	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SYVN1 蛋白结构

zf-RING_2

0
100
200
300
400
500
617 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase synoviolin

HMG-coA reductase degradation 1 homolog

SYVN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Anti Bait CoIP	31477895
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Confocal	31477895
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Pull Down	31477895
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Anti Tag CoIP	31477895
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Density Sedimentation	31477895
种属内	SYVN1	Q86TM6	USP15	Homo sapiens	Q9Y4E8	Y2H	31477895
种属内	SYVN1	Q86TM6	SEL1L	Homo sapiens	Q9UBV2	Anti Bait CoIP	28827405
种属内	SYVN1	Q86TM6	SEL1L	Homo sapiens	Q9UBV2	Anti Tag CoIP	35271311
种属内	SYVN1	Q86TM6	SEL1L	Homo sapiens	Q9UBV2	Pull Down	22119785
种属内	SYVN1	Q86TM6	SEL1L	Homo sapiens	Q9UBV2	Anti Tag CoIP	31477895
种属内	SYVN1	Q86TM6	SEL1L	Homo sapiens	Q9UBV2	Affinity Chrom	28827405
种属内	SYVN1	Q86TM6	ERLIN1	Homo sapiens	O75477	Pull Down	22119785
种属内	SYVN1	Q86TM6	TP53	Homo sapiens	P04637	Anti Bait CoIP	17170702
种属内	SYVN1	Q86TM6	ERN1	Homo sapiens	O75460	Anti Bait CoIP	18369366
种属内	SYVN1	Q86TM6	ERN1	Homo sapiens	O75460	Anti Tag CoIP	18369366
种属内	SYVN1	Q86TM6	ERLIN2	Homo sapiens	O94905	Anti Tag CoIP	21343306
种属内	SYVN1	Q86TM6	ERLIN2	Homo sapiens	O94905	Pull Down	22119785
种属内	SYVN1	Q86TM6	FAM8A1	Homo sapiens	Q9UBU6	Anti Bait CoIP	28827405
种属内	SYVN1	Q86TM6	FAM8A1	Homo sapiens	Q9UBU6	Pull Down	22119785
种属内	SYVN1	Q86TM6	FAM8A1	Homo sapiens	Q9UBU6	Affinity Chrom	28827405
种属内	SYVN1	Q86TM6	UBE2J1	Homo sapiens	Q9Y385	Pull Down	22119785
种属内	SYVN1	Q86TM6	UBE2J1	Homo sapiens	Q9Y385	Anti Bait CoIP	28827405
种属内	SYVN1	Q86TM6	UBE2J1	Homo sapiens	Q9Y385	Affinity Chrom	28827405

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Spinocerebellar Ataxia, Autosomal Recessive 6

SCAR6	Norwegian Infantile Onset Ataxia
Autosomal Recessive Spinocerebellar Ataxia 6	Autosomal Recessive Spinocerebellar Ataxia Type 6
Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia	Cerebellar Ataxia, Infantile Nonprogressive, Autosomal Recessive
Spinocerebellar Ataxia Autosomal Recessive 6	Cerebellar Ataxia Infantile Nonprogressive Autosomal Recessive

Arthropathy

Ankylosis Of Ankle And Foot Joint	Ankylosis Of Forearm Joint
Ankylosis Of Hand Joint	Ankylosis Of Joint Of Ankle And/Or Foot
Ankylosis Of Joint Of Forearm	Ankylosis Of Joint Of Hand
Ankylosis Of Joint Of Lower Leg	Ankylosis Of Joint Of Multiple Sites
Ankylosis Of Joint Of Pelvic Region And Thigh	Ankylosis Of Joint Of Shoulder Region
Ankylosis Of Joint Of Upper Arm	Ankylosis Of Lower Leg Joint
Ankylosis Of Multiple Joints	Ankylosis Of Upper Arm Joint
Infectious Arthropathy	Joint Ankylosis Of The Ankle And Foot
Joint Ankylosis Of The Ankle And/Or Foot	Joint Ankylosis Of The Forearm
Joint Ankylosis Of The Hand	Joint Ankylosis Of The Lower Leg
Joint Ankylosis Of The Pelvic Region And Thigh	Joint Ankylosis Of The Shoulder Region
Joint Ankylosis Of The Upper Arm	Joint Diseases
Joint Disease	Arthropathy Associated With Infection

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-135844	LS-102	Inhibitor	97.92%	否
HY-RS14127	SYVN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SYVN1	RGD	RGD:1310488
Canis familiaris	SYVN1	VGNC	VGNC:47055
Felis catus	SYVN1	VGNC	VGNC:65909
Macaca mulatta	SYVN1	VGNC	VGNC:78183
Bos taurus	SYVN1	VGNC	VGNC:56285
Mus musculus	SYVN1	MGD	MGI:1921376

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SYVN1 - synoviolin 1 Gene

关于 SYVN1

功能概要

SYVN1 基因产物(2)

SYVN1 蛋白结构

SYVN1 蛋白互作信息

关联疾病

直系同源

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SYVN1 - synoviolin 1 Gene

关于 SYVN1

功能概要

SYVN1 基因产物(2)

SYVN1 蛋白结构

SYVN1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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F

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