SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Gene

中文名称：ERAD E3 泛素连接酶的 SEL1L 接头亚基

种属: Homo sapiens

同用名: Hrd3; SEL1L1; PRO1063; SEL1-LIKE

基因 ID: 6400 | 基因类型: protein coding

关于 SEL1L

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,471,547-81,533,853 (from NCBI)

This gene has 6 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 48.9), thyroid (RPKM 38.9) and 25 other tissues.

功能概要

由该基因编码的蛋白质是错误折叠的蛋白质从内质网腔逆向易位或错位到胞质溶胶所需的蛋白质复合物的一部分，在那里它们以泛素依赖性方式被蛋白酶体降解。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the Proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEL1L 基因产物(2)

mRNA	Protein	Name
NM_001244984.2	NP_001231913.1	protein sel-1 homolog 1 isoform 2 precursor
NM_005065.6	NP_005056.3	protein sel-1 homolog 1 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18264092	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	21454652	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: 通过突变表型推断	25660456	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Derlin-1 retrotranslocation complex	IDA IDA: 通过直接分析推断	21454652	GOA
part of Hrd1p ubiquitin ligase ERAD-L complex	IMP IMP: 通过突变表型推断	26471130	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	26471130	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEL1L 蛋白结构

fn2

Sel1

0
200
400
600
794 a.a.

蛋白主名

其他名称

protein sel-1 homolog 1

SEL1L, ERAD E3 ligase adaptor subunit

SEL1L 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SEL1L	Q9UBV2	FOXRED2	Homo sapiens	Q8IWF2	Anti Bait CoIP	19706418
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Tag CoIP	18711132
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Bait CoIP	28827405
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Pull Down	22119785
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Bait CoIP	29496332
Intra	SEL1L	Q9UBV2	SYVN1	Homo sapiens	Q86TM6	Pull Down	22119785
Intra	SEL1L	Q9UBV2	SYVN1	Homo sapiens	Q86TM6	Anti Bait CoIP	28827405

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 1 Diabetes Mellitus 11

Diabetes Mellitus, Insulin-Dependent, 11	Iddm11
Insulin-Dependent Diabetes Mellitus 11	T1D11
Insulin-Dependent Diabetes Mellitus-11

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Lipase Deficiency, Combined

Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency	Lpl And Htgl Deficiency
Lpl And Hl Deficiency	Familial Lipase Maturation Factor 1 Deficiency
Lipase Deficiency Combined	Combined Lipase Deficiency
Familial Lmf1 Deficiency	CLD

Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10	IDDM10
Insulin-Dependent Diabetes Mellitus 10	Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10
T1D10	Diabetes, Mellitus, Insulin-Dependent 10
Diabetes Mellitus, Insulin-Dependent, Type 10

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12630	SEL1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12631	SEL1L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SEL1L	VGNC	VGNC:77155
Rattus norvegicus	SEL1L	RGD	RGD:620147
Mus musculus	SEL1L	MGD	MGI:1329016
Felis catus	SEL1L	VGNC	VGNC:64978
Canis familiaris	SEL1L	VGNC	VGNC:54990
Bos taurus	SEL1L	VGNC	VGNC:49962

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Gene

关于 SEL1L

功能概要

SEL1L 基因产物(2)

SEL1L 蛋白结构

SEL1L 蛋白互作信息

关联疾病

直系同源

热门区域

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SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Gene

关于 SEL1L

功能概要

SEL1L 基因产物(2)

SEL1L 蛋白结构

SEL1L 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z