2. Gene
  3. OS9 - OS9 endoplasmic reticulum lectin Gene

OS9 - OS9 endoplasmic reticulum lectin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：OS9 内质网凝集素

种属: Homo sapiens

同用名: OS-9; ERLEC2

基因 ID: 10956 | 基因类型: protein coding

关于 OS9

Cytogenetic location: 12q13.3-q14.1 Genomic coordinates (GRCh38): 12:57,694,132-57,721,557 (from NCBI)

This gene has 37 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 82.8), thyroid (RPKM 81.3) and 25 other tissues.

功能概要

该基因编码一种在骨肉瘤中高表达的蛋白质。这种蛋白质与缺氧诱导因子 1 (HIF-1) 结合，HIF-1 是缺氧反应和血管生成的关键调节因子，并促进其亚基之一的降解。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OS9 基因产物(11)

mRNA Protein Name
NM_001017956.3 NP_001017956.1 protein OS-9 isoform 2 precursor
NM_001017957.3 NP_001017957.1 protein OS-9 isoform 3 precursor
NM_001017958.3 NP_001017958.1 protein OS-9 isoform 4 precursor
NM_001261420.2 NP_001248349.1 protein OS-9 isoform 5 precursor
NM_001261421.2 NP_001248350.1 protein OS-9 isoform 6 precursor
NM_001261422.2 NP_001248351.1 protein OS-9 isoform 7 precursor
NM_001261423.2 NP_001248352.1 protein OS-9 isoform 8 precursor
NM_001410978.1 NP_001397907.1 protein OS-9 isoform 9 precursor
NM_001410979.1 NP_001397908.1 protein OS-9 isoform 10 precursor
NM_001410980.1 NP_001397909.1 protein OS-9 isoform 11 precursor
NM_006812.4 NP_006803.1 protein OS-9 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IDA
IDA: 通过直接分析推断
18264092 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15721254 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
18264092 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: 通过突变表型推断
25660456 GOA
involved in protein retention in ER lumen IDA
IDA: 通过直接分析推断
18417469 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
19084021 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
19084021 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19084021 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
18264092 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OS9 蛋白结构

PRKCSH

PRKCSH: Glucosidase II beta subunit-like protein (110 - 181)

  • 0
  • 200
  • 400
  • 600
  • 667 a.a.
蛋白主名 其他名称

protein OS-9

amplified in osteosarcoma 9

OS9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra OS9 Q13438 EGLN1 Homo sapiens Q9GZT9
Anti Tag CoIP
15721254
Intra OS9 Q13438 ERN1 Homo sapiens O75460-1
Anti Tag CoIP
26551274
Intra OS9 Q13438 NXPE3 Homo sapiens Q969Y0
Anti Tag CoIP
33961781
Intra OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Pull Down
22119785
Intra OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
26551274
Intra OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
33961781
Intra OS9 Q13438 HIF1A Homo sapiens Q16665
Anti Tag CoIP
15721254
Intra OS9 Q13438 HIF1A Homo sapiens Q16665
Pull Down
15721254
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies

FENIB

Encephalopathy, Familial, With Collins Bodies

Familial Dementia With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Collins Bodies
Erythrocytosis, Familial, 3

ECYT3

Familial Erythrocytosis 3

Erythrocytosis, Familial, Type 3
Erythrocytosis, Familial, 5

ECYT5

Familial Erythrocytosis 5
Fibrosarcomatous Osteosarcoma

Fibroblastic Osteosarcoma

Fibrosarcomatous Osteogenic Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09834 OS9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus OS9 VGNC VGNC:63975
Macaca mulatta OS9 VGNC VGNC:75635
Bos taurus OS9 VGNC VGNC:32455
Mus musculus OS9 MGD MGI:1924301
Rattus norvegicus OS9 RGD RGD:1359574
Canis familiaris OS9 VGNC VGNC:44148
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