USP15 - ubiquitin specific peptidase 15 Gene

中文名称：泛素特异性肽酶 15

种属: Homo sapiens

同用名: UNPH4; UNPH-2

基因 ID: 9958 | 基因类型: protein coding

关于 USP15

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:62,260,404-62,416,389 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues.

功能概要

该基因编码泛素特异性蛋白酶 (USP) 去泛素化酶家族的成员。 USP 酶通过多聚泛素链分解和泛素-底物键的水解，在泛素依赖过程中发挥关键作用。编码的蛋白质与 COP9 信号体相关联，并且还通过受体激活的 SMAD 转录因子的去泛素化在转化生长因子 β 信号传导中发挥作用。已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 2 号染色体的长臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the ubiquitin specific Protease (USP) family of deubiquitinating Enzymes. USP Enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP15 基因产物(11)

mRNA	Protein	Name
NM_001252078.2	NP_001239007.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 1
NM_001252079.2	NP_001239008.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 3
NM_001351159.2	NP_001338088.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 4
NM_001351160.2	NP_001338089.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 5
NM_001351161.2	NP_001338090.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 6
NM_001351162.2	NP_001338091.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 7
NM_001351163.2	NP_001338092.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351164.2	NP_001338093.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351165.2	NP_001338094.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351166.2	NP_001338095.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_006313.3	NP_006304.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables K48-linked deubiquitinase activity	IDA IDA: 通过直接分析推断	24399297	GOA
enables SMAD binding	IPI IPI: 通过物理相互作用推断	21947082	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: 通过直接分析推断	16005295	GOA
enables cysteine-type endopeptidase activity	IMP IMP: 通过突变表型推断	21947082	GOA
enables deubiquitinase activity	IDA IDA: 通过直接分析推断	32839293	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	22001210	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21209336	GOA
enables transforming growth factor beta receptor binding	IPI IPI: 通过物理相互作用推断	22344298	GOA
enables ubiquitin-modified histone reader activity	IDA IDA: 通过直接分析推断	24526689	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in BMP signaling pathway	IDA IDA: 通过直接分析推断	21947082	GOA
involved in monoubiquitinated protein deubiquitination	IDA IDA: 通过直接分析推断	21947082	GOA
involved in negative regulation of antifungal innate immune response	IDA IDA: 通过直接分析推断	33093067	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	22344298	GOA
involved in positive regulation of RIG-I signaling pathway	IDA IDA: 通过直接分析推断	24399297	GOA
involved in protein K27-linked deubiquitination	IDA IDA: 通过直接分析推断	33093067	GOA
involved in protein deubiquitination	IDA IDA: 通过直接分析推断	16005295	GOA
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: 通过直接分析推断	24526689	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	21947082	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	21947082	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21947082	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP15 蛋白结构

DUSP

Ubiquitin_3

UCH

0
200
400
600
800
981 a.a.

蛋白主名

其他名称

ubiquitin carboxyl-terminal hydrolase 15

deubiquitinating enzyme 15

关联疾病

疾病名称

别名

Microphthalmia, Isolated 1

Isolated Microphthalmia 1	MCOP1
Mcop	Anophthalmia, Clinical, Isolated
Microphthalmos, Autosomal Recessive

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148046	USP15-IN-1	Inhibitor	99.42%	否
HY-RS15526	USP15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	USP15	VGNC	VGNC:66869
Bos taurus	USP15	VGNC	VGNC:36713
Macaca mulatta	USP15	VGNC	VGNC:78737
Mus musculus	USP15	MGD	MGI:101857
Rattus norvegicus	USP15	RGD	RGD:628795
Canis familiaris	USP15	VGNC	VGNC:48180
Others	USP15	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

USP15 - ubiquitin specific peptidase 15 Gene

关于 USP15

功能概要

USP15 基因产物(11)

USP15 蛋白结构

关联疾病

直系同源

热门区域

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USP15 - ubiquitin specific peptidase 15 Gene

关于 USP15

功能概要

USP15 基因产物(11)

USP15 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z