1. Gene
  2. TIFAB - TIFA inhibitor Gene

TIFAB - TIFA inhibitor Gene

中文名称:TIFA 抑制因子

种属: Homo sapiens

基因 ID: 497189 | 基因类型: protein coding

关于 TIFAB

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,444,226-135,452,351 (from NCBI)

This gene has 1 transcript (splice variant), 73 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 4.5), appendix (RPKM 3.4) and 12 other tissues.

功能概要

TIFAB 与 TIFA (MIM 609028) 结合并抑制 TIFA 介导的 NF-kappa-B 激活 (NFKB1;MIM 164011) (Matsumura 等人,2004 [PubMed 15047173]) 。[OMIM 提供,2009 年 3 月]

TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

TIFAB 基因产物(1)

mRNA Protein Name
NM_001099221.2 NP_001092691.1 TRAF-interacting protein with FHA domain-containing protein B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15047173 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in auditory behavior IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in cochlea development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in cochlea morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in craniofacial suture morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in genitalia development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in genitalia morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in hard palate morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in inner ear development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in learned vocalization behavior IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in mastication IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in negative regulation of relaxation of muscle IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in negative regulation of saliva secretion IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in peristalsis IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in regulation of muscle organ development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in thorax and anterior abdomen determination IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in trigeminal nerve development IGI
IGI: 通过遗传相互作用推断
23419067 GOA
involved in vestibulocochlear nerve formation IGI
IGI: 通过遗传相互作用推断
23419067 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TIFAB 蛋白结构

FHA

FHA: FHA domain (37 - 107)

  • 0
  • 100
  • 161 a.a.
蛋白主名 其他名称

TRAF-interacting protein with FHA domain-containing protein B

TIFA-like protein

TIFAB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TIFAB Q6ZNK6 USP15 Homo sapiens Q9Y4E8
Anti Tag CoIP
32101751
种属内
TIFAB Q6ZNK6 USP15 Homo sapiens Q9Y4E8
TAP
32101751
种属内
TIFAB Q6ZNK6 TIFA Homo sapiens Q96CG3
TAP
32101751
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TIFAB VGNC VGNC:47367
Mus musculus TIFAB MGD MGI:2385852
Felis catus TIFAB VGNC VGNC:102344
Rattus norvegicus TIFAB RGD RGD:1311681
Macaca mulatta TIFAB VGNC VGNC:79944
Bos taurus TIFAB VGNC VGNC:52889