TIFA - TRAF interacting protein with forkhead associated domain Gene

中文名称：具有叉头相关结构域的 TRAF 相互作用蛋白

种属: Homo sapiens

同用名: T2BP; T6BP; TIFAA

关于 TIFA

功能概要

该基因编码一种参与适应性和先天性免疫的衔接蛋白。该蛋白质包含一个叉头相关 (FHA) 结构域，可特异性结合磷酸化的丝氨酸和苏氨酸残基。为了响应细菌感染，编码的宿主细胞蛋白在 FHA 结构域和磷酸化苏氨酸之间发生分子间相互作用，导致蛋白质寡聚化并刺激 NF-kappa B 和其他下游信号通路。该蛋白在肝细胞癌中表现出降低的表达，并可能抑制肝细胞癌的进展。这种蛋白质也可能在 DNA 损伤反应中发挥作用。[RefSeq 提供，2018 年 6 月]

This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to Bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and Other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]