Traf6 - TNF receptor-associated factor 6 Gene

种属: Mus musculus

同用名: 2310003F17Rik; C630032O20Rik

基因 ID: 22034 | 基因类型: protein coding

关于 Traf6

功能概要

This gene encodes a member of the TNF Receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF Receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin Ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Traf6 基因产物(2)

mRNA	Protein	Name
NM_001303273.1	NP_001290202.1	TNF receptor-associated factor 6
NM_009424.3	NP_033450.2	TNF receptor-associated factor 6

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	8910514	MGI
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	15361868	MGI
enables ubiquitin protein ligase activity	IGI IGI: 通过遗传相互作用推断	22863753	MGI
enables ubiquitin protein ligase activity	IMP IMP: 通过突变表型推断	23042151	MGI
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	16252010	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within T-helper 1 type immune response	IMP IMP: 通过突变表型推断	14499111	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: 通过突变表型推断	15705807	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: 通过突变表型推断	14499111	MGI
involved in bone remodeling	IMP IMP: 通过突变表型推断	10421844	MGI
involved in bone resorption	IMP IMP: 通过突变表型推断	10215628	MGI
involved in canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	17633018	MGI
acts upstream of or within cell development	IMP IMP: 通过突变表型推断	15705807	MGI
acts upstream of or within immune response	IMP IMP: 通过突变表型推断	15705807	MGI
acts upstream of or within in utero embryonic development	IMP IMP: 通过突变表型推断	27996060	MGI
involved in interleukin-1-mediated signaling pathway	IMP IMP: 通过突变表型推断	10421844	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: 通过直接分析推断	19825828	MGI
involved in interleukin-17-mediated signaling pathway	IMP IMP: 通过突变表型推断	19825828	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IGI IGI: 通过遗传相互作用推断	26458771	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	26458771	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: 通过突变表型推断	14499111	MGI
involved in neural tube closure	IMP IMP: 通过突变表型推断	11007897	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: 通过突变表型推断	14699584	MGI
acts upstream of or within ossification	IMP IMP: 通过突变表型推断	10215628	MGI
involved in osteoclast differentiation	IMP IMP: 通过突变表型推断	10421844	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	20345905	MGI
involved in positive regulation of T cell proliferation	IMP IMP: 通过突变表型推断	10421844	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: 通过遗传相互作用推断	22863753	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	15322147	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: 通过突变表型推断	14499111	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	14499111	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	10215628	MGI
involved in positive regulation of type I interferon production	IDA IDA: 通过直接分析推断	15361868	MGI
involved in protein K63-linked ubiquitination	IDA IDA: 通过直接分析推断	16252010	MGI
involved in protein polyubiquitination	IMP IMP: 通过突变表型推断	19825828	MGI
acts upstream of or within protein ubiquitination	IDA IDA: 通过直接分析推断	23042151	MGI
acts upstream of or within protein ubiquitination	IGI IGI: 通过遗传相互作用推断	22095711	MGI
acts upstream of or within regulation of immunoglobulin production	IDA IDA: 通过直接分析推断	12958312	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	28973854	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: 通过表达模式推断	28973854	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: 通过突变表型推断	28973854	MGI
acts upstream of or within signal transduction	IDA IDA: 通过直接分析推断	12958312	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CD40 receptor complex	IDA IDA: 通过直接分析推断	20614026	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: 通过直接分析推断	20614026	MGI
located in cytosol	IDA IDA: 通过直接分析推断	16831874	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	28973854	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	28973854	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	28973854	MGI
located in lipid droplet	IDA IDA: 通过直接分析推断	21435586	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

TNF receptor-associated factor 6

E3 ubiquitin-protein ligase TRAF6

RING-type E3 ubiquitin transferase TRAF6

Traf6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Traf6	P70196	Trafd1	Mus musculus	Q3UDK1	Pull Down	16221674
种属内	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19091944
种属内	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19815506
种属内	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	18083102
种属内	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19131965
种属内	Traf6	P70196	Nr0b2	Mus musculus	Q62227	Anti Bait CoIP	21725320
种属内	Traf6	P70196	Map3k3	Mus musculus	Q61084	Anti Bait CoIP	16362041
种属内	Traf6	P70196	Map3k3	Mus musculus	Q61084	CoIP	14661019
种属内	Traf6	P70196	Irak1	Mus musculus	Q62406-1	Y2H	15102471
种属内	Traf6	P70196	Cd40	Mus musculus	P27512	Y2H	8910514
种属内	Traf6	P70196	Cd40	Mus musculus	P27512	Pull Down	8910514
种属内	Traf6	P70196	Ecsit	Mus musculus	Q9QZH6	Y2H	15102471
种属内	Traf6	P70196	Ecsit	Mus musculus	Q9QZH6	Y2H	10465784
种属内	Traf6	P70196	Traf3ip2	Mus musculus	Q8C0E5	Anti Tag CoIP	12459498
种属内	Traf6	P70196	Ern1	Mus musculus	Q9EQY0	Anti Bait CoIP	23942232
种属内	Traf6	P70196	Ern1	Mus musculus	Q9EQY0	Anti Tag CoIP	23942232
种属内	Traf6	P70196	Traf3ip2	Mus musculus	Q8N7N6	Y2H	15102471
种属内	Traf6	P70196	Irak3	Mus musculus	Q8K4B2	Y2H	15102471
种属内	Traf6	P70196	Tnfrsf11a	Mus musculus	O35305	Y2H	10097072
种属间	Traf6	P70196	TIFA	Homo sapiens	Q96CG3	Anti Tag CoIP	15047173

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120934	C25-140	Inhibitor	99.86%	否
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	否
HY-P3709A	TRAF6 peptide TFA	Inhibitor	95.99%	否
HY-P3709	TRAF6 peptide	Inhibitor	/	否
HY-164670	D228		99.77%	否
HY-125025	SMI 6860766	Inhibitor	/	否
HY-P3708	TRAF6 control peptide	Control	/	否
HY-RS14975	TRAF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Traf6	NCBI	NCBI:7189

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Traf6 - TNF receptor-associated factor 6 Gene

关于 Traf6

功能概要

Traf6 基因产物(2)

Traf6 蛋白互作信息

直系同源

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Traf6 - TNF receptor-associated factor 6 Gene

关于 Traf6

功能概要

Traf6 基因产物(2)

Traf6 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z