2. Gene
  3. Irak3 - interleukin-1 receptor-associated kinase 3 Gene

Irak3 - interleukin-1 receptor-associated kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: IRAK-M; 4833428C18Rik

基因 ID: 73914 | 基因类型: protein coding

关于 Irak3

功能概要

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macrophage tolerance induction; and response to molecule of Bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Irak3 基因产物(2)

mRNA Protein Name
NM_001359184.1 NP_001346113.1 interleukin-1 receptor-associated kinase 3 isoform 2
NM_028679.4 NP_082955.2 interleukin-1 receptor-associated kinase 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12054681 MGI
enables magnesium ion binding IDA
IDA: 通过直接分析推断
12054681 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
12054681 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12054681 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
12054681 MGI
acts upstream of or within interleukin-1-mediated signaling pathway IDA
IDA: 通过直接分析推断
12054681 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
17379480 MGI
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
12150927 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
12150927 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
12150927 MGI
involved in negative regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
12150927 MGI
involved in negative regulation of protein catabolic process IMP
IMP: 通过突变表型推断
17379480 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
12150927 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
12150927 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
12054681 MGI
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
29686383 MGI
involved in positive regulation of macrophage tolerance induction IMP
IMP: 通过突变表型推断
12150927 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
12054681 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12054681 MGI
involved in regulation of protein-containing complex disassembly IDA
IDA: 通过直接分析推断
12054681 MGI
involved in response to exogenous dsRNA IMP
IMP: 通过突变表型推断
12150927 MGI
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
12150927 MGI
involved in response to peptidoglycan IMP
IMP: 通过突变表型推断
12150927 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17379480 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17379480 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-1 receptor-associated kinase 3

IL-1 receptor-associated kinase M

inactive IL-1 receptor-associated kinase 3

Irak3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Irak3 Q8K4B2 Irak4 Mus musculus Q8R4K2
Anti Bait CoIP
23376919
种属内
Irak3 Q8K4B2 Traf6 Mus musculus P70196
Anti Tag CoIP
23376919
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142662A PROTAC IRAK3 degrade-1 formic 98.10% 否
HY-142662 PROTAC IRAK3 degrade-1 Modulator / 否
HY-RS06897 IRAK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irak3 NCBI NCBI:11213
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