IRAK3 - interleukin 1 receptor associated kinase 3 Gene

中文名称：白介素 1 受体相关激酶 3

种属: Homo sapiens

同用名: ASRT5; IRAKM

基因 ID: 11213 | 基因类型: protein coding

关于 IRAK3

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,189,214-66,254,622 (from NCBI)

This gene has 3 transcripts (splice variants), 154 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 10.8), spleen (RPKM 8.1) and 21 other tissues.

功能概要

该基因编码白介素-1 受体相关激酶蛋白家族的成员。该家族的成员是 Toll/IL-R 免疫信号转导通路的重要组成部分。这种蛋白质主要在单核细胞和巨噬细胞中表达，并作为 Toll 样受体信号传导的负调节剂发挥作用。该基因的突变与哮喘易感性有关。交替剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like Receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

IRAK3 基因产物(2)

mRNA	Protein	Name
NM_001142523.2	NP_001135995.1	interleukin-1 receptor-associated kinase 3 isoform b
NM_007199.3	NP_009130.2	interleukin-1 receptor-associated kinase 3 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	10383454	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	10383454	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	29686383	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	10383454	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	33238146	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	10383454	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	33238146	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	10383454	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in interleukin-1-mediated signaling pathway	IMP IMP: 通过突变表型推断	10383454	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: 通过突变表型推断	17379480	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	10383454	GOA
involved in negative regulation of interleukin-12 production	IMP IMP: 通过突变表型推断	18156187	GOA
involved in negative regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	18156187	GOA
involved in negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	17379480	GOA
involved in negative regulation of protein-containing complex disassembly	IMP IMP: 通过突变表型推断	12150927	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	15728517	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	10383454	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	10383454	GOA
involved in response to interleukin-1	IMP IMP: 通过突变表型推断	10383454	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17379480	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17379480	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRAK3 蛋白结构

Death

Pkinase

0
100
200
300
400
500
596 a.a.

蛋白主名

其他名称

interleukin-1 receptor-associated kinase 3

IL-1 receptor-associated kinase M

IRAK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	IRAK3	Q9Y616	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	10383454
Intra	IRAK3	Q9Y616	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	IRAK3	Q9Y616	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Asthma-Related Traits 5

Asthma-Related Traits, Susceptibility To, 5	ASRT5
Asthma Susceptibility 5	Asthma-Related Traits, Susceptibility To, Type 5

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Deafness, Autosomal Recessive 74

DFNB74	Autosomal Recessive Nonsyndromic Deafness 74
Autosomal Recessive Deafness 74	Deafness, Autosomal Recessive, 74
Deafness, Autosomal Recessive, Type 74

Pleuropneumonia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-142662A	PROTAC IRAK3 degrade-1 formic		98.10%	否
HY-142662	PROTAC IRAK3 degrade-1	Modulator	/	否
HY-RS06897	IRAK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IRAK3	MGD	MGI:1921164
Bos taurus	IRAK3	VGNC	VGNC:30267
Rattus norvegicus	IRAK3	RGD	RGD:1308846
Felis catus	IRAK3	VGNC	VGNC:62971
Macaca mulatta	IRAK3	VGNC	VGNC:81423
Canis familiaris	IRAK3	VGNC	VGNC:54151
Others	IRAK3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IRAK3 - interleukin 1 receptor associated kinase 3 Gene

关于 IRAK3

功能概要

IRAK3 基因产物(2)

IRAK3 蛋白结构

IRAK3 蛋白互作信息

关联疾病

直系同源

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IRAK3 - interleukin 1 receptor associated kinase 3 Gene

关于 IRAK3

功能概要

IRAK3 基因产物(2)

IRAK3 蛋白结构

IRAK3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z