Cd40 - CD40 antigen Gene

种属: Mus musculus

同用名: IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5

基因 ID: 21939 | 基因类型: protein coding

关于 Cd40

功能概要

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein Ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to Other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd40 基因产物(4)

mRNA	Protein	Name
NM_011611.2	NP_035741.2	tumor necrosis factor receptor superfamily member 5 isoform 1 precursor
NM_170702.2	NP_733803.2	tumor necrosis factor receptor superfamily member 5 isoform 5 precursor
NM_170703.2	NP_733804.1	tumor necrosis factor receptor superfamily member 5 isoform 2 precursor
NM_170704.2	NP_733805.1	tumor necrosis factor receptor superfamily member 5 isoform 4 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	8910514	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B cell activation	IDA IDA: 通过直接分析推断	14594818	MGI
involved in B cell mediated immunity	IGI IGI: 通过遗传相互作用推断	18624351	MGI
acts upstream of B cell proliferation	IDA IDA: 通过直接分析推断	8666928	MGI
acts upstream of B cell proliferation	IGI IGI: 通过遗传相互作用推断	15963492	MGI
involved in CD40 signaling pathway	IGI IGI: 通过遗传相互作用推断	18624351	MGI
acts upstream of or within defense response to protozoan	IDA IDA: 通过直接分析推断	19047410	MGI
acts upstream of or within defense response to virus	IDA IDA: 通过直接分析推断	17277142	MGI
acts upstream of or within immune response-regulating cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	15240714	MGI
involved in immunoglobulin production	IGI IGI: 通过遗传相互作用推断	18624351	MGI
acts upstream of interleukin-12 production	IDA IDA: 通过直接分析推断	15240714	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: 通过突变表型推断	21410936	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	16546095	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: 通过直接分析推断	8666928	MGI
acts upstream of or within positive regulation of B cell proliferation	IGI IGI: 通过遗传相互作用推断	15963492	MGI
acts upstream of or within positive regulation of interleukin-12 production	IDA IDA: 通过直接分析推断	15240714	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IDA IDA: 通过直接分析推断	12882831	MGI
acts upstream of or within regulation of immune response	IDA IDA: 通过直接分析推断	12882831	MGI
acts upstream of or within regulation of immunoglobulin production	IDA IDA: 通过直接分析推断	12958312	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CD40 receptor complex	IDA IDA: 通过直接分析推断	20614026	MGI
located in cell surface	IDA IDA: 通过直接分析推断	20685650	MGI
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	8566034	MGI
located in intracellular membrane-bounded organelle	IDA IDA: 通过直接分析推断	16708399	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	20614026	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

tumor necrosis factor receptor superfamily member 5

B-cell surface antigen CD40	CD40L receptor
T-cell differentiation antigen

Cd40 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Cd40	P27512	Traf2	Mus musculus	P39429	Anti Bait CoIP	23334419
Intra	Cd40	P27512	Btk	Mus musculus	P35991	Confocal	21441935
Intra	Cd40	P27512	Btk	Mus musculus	P35991	Anti Tag CoIP	21441935

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Cd40 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72724	CD40 Protein, Mouse (HEK293, His)	P27512-1 (L20-R193)	≥95%
HY-P72911	CD40 Protein, Mouse (HEK293, Fc)	P27512-1 (L20-R193)	≥95%
HY-P74298	CD40 Protein, Mouse (Biotinylated , HEK293, His-Avi)	P27512-1/NP_035741.2 (L20-R193)	≥95%

相关产品

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-B1618	Corticosterone	Agonist	99.76%	Phase 3
HY-131968	BMS-986202	Inhibitor	99.92%	Phase 1

抗体抑制剂 (10)

目录号	产品名	作用方式	纯度	Phase
HY-P99625	Frexalimab	Inhibitor	99.00%	Phase 3
HY-P99670	Iscalimab	Inhibitor	99.64%	Phase 2
HY-P99742	Mitazalimab	Inhibitor	98.74%	Phase 2
HY-P99167	Lucatumumab	Inhibitor	98.18%	Phase 2
HY-P99015	Dacetuzumab	Inhibitor	95.37%	Phase 2
HY-P99315	Ruplizumab	Inhibitor	99.84%	Phase 2
HY-P99701	Letolizumab	Inhibitor	95.00%	Phase 2
HY-P99821	Ravagalimab	Inhibitor	99.31%	Phase 2
HY-P99572	Tecaginlimab	Inhibitor	99.00%	Phase 2
HY-P99325	Toralizumab	Inhibitor	99.57%	Phase 1

Pre-clinical Phase

生物活性分子 (21)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-122663A	BIO8898	Inhibitor	99.88%	否
HY-120323	DRI-C21045	Inhibitor	99.02%	否
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	否
HY-148980A	Polyinosinic acid sodium		/	否
HY-154821A	DRI-C21041 (DIEA)	Inhibitor	/	否
HY-153345	Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br	Agonist	99.67%	否
HY-122663	(Rac)-BIO8898	Inhibitor	99.81%	否
HY-16668	Tyrphostin A1	Inhibitor	98.96%	否
HY-152121	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Agonist	95.21%	否
HY-154822	DRI-C25441	Inhibitor	99.53%	否
HY-154821	DRI-C21041	Inhibitor	/	否
HY-148980	Polyinosinic acid		/	否
HY-125025	SMI 6860766	Inhibitor	/	否
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	否
HY-148459	ATAC21		/	否
HY-D1124	Mordant brown 1		/	否
HY-P10399	KGYY15	Inhibitor	/	否
HY-RS02246	CD40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02247	CD40LG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-120471	AM-0687	Inhibitor	/	否
HY-400878	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	Agonist	99.86%	否

抗体抑制剂 (4)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99663	Inezetamab	Inhibitor	99.77%	否
HY-P99842A	Dapirolizumab	Inhibitor	99.40%	否
HY-P99321	Teneliximab	Inhibitor	≥99.0%	否
HY-P990111	BMS-986325 (anti-CD40)	Inhibitor	96.46%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cd40	NCBI	NCBI:958
Canis familiaris	Cd40	NCBI	NCBI:403469
Macaca fascicularis	Cd40	NCBI	NCBI:102118696
Leporidae	Cd40	NCBI
Rattus norvegicus	Cd40	NCBI	NCBI:171369
Macaca mulatta	Cd40	NCBI	NCBI:707749

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