Tecaginlimab  (Synonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042)

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Bispecific; Humanized

Tecaginlimab 结合重组人 CD40 和 4-1BB，亲和力分别为 1.0 nM 和 0.17 nM^[1]。
Tecaginlimab (0.001-1 µg/mL; 5 d) 在体外诱导树突状细胞 (DC) 成熟^[1]。
Tecaginlimab (0.2 µg/mL; 10-15 d) 在体外增强 T 细胞活化^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tecaginlimab (0.0008-0.2 µg/mL; 4 d) 增强肿瘤浸润淋巴细胞的扩增^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2253891-70-0

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• 
  Loaded Tecaginlimab on AHC2 biosensor, can bind 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) with an affinity constant of 5.270E-11 M as determined in BLI assay.

• [1]. Muik A, et, al. DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity. J Immunother Cancer. 2022 Jun;10(6):e004322.  [Content Brief]