MAD1L1 - mitotic arrest deficient 1 like 1 Gene

中文名称：有丝分裂停滞缺陷 1 样 1

种属: Homo sapiens

同用名: MAD1; PIG9; TP53I9; TXBP181

基因 ID: 8379 | 基因类型: protein coding

关于 MAD1L1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,815,795-2,232,945 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues.

功能概要

MAD1L1 是有丝分裂纺锤体组装检查点的一个组成部分，可防止后期开始，直到所有染色体在中期板上正确对齐。 MAD1L1 作为同型二聚体发挥作用并与 MAD2L1 相互作用。 MAD1L1 可能在细胞周期控制和肿瘤抑制中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

MAD1L1 基因产物(6)

mRNA	Protein	Name
NM_001013836.2	NP_001013858.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001013837.2	NP_001013859.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304523.2	NP_001291452.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304524.2	NP_001291453.1	mitotic spindle assembly checkpoint protein MAD1 isoform b precursor
NM_001304525.2	NP_001291454.1	mitotic spindle assembly checkpoint protein MAD1 isoform c
NM_003550.3	NP_003541.2	mitotic spindle assembly checkpoint protein MAD1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables kinetochore binding	IDA IDA: 通过直接分析推断	18981471	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12006501	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic sequestering of protein	IDA IDA: 通过直接分析推断	19010891	GOA
involved in deactivation of mitotic spindle assembly checkpoint	IDA IDA: 通过直接分析推断	19010891	GOA
involved in mitotic spindle assembly checkpoint signaling	IDA IDA: 通过直接分析推断	18981471	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: 通过突变表型推断	9546394	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IDA IDA: 通过直接分析推断	22898774	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: 通过突变表型推断	36322655	GOA
involved in regulation of metaphase plate congression	IDA IDA: 通过直接分析推断	20133940	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MAD1 complex	IPI IPI: 通过物理相互作用推断	22493223	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19010891	GOA
colocalizes with kinetochore	IDA IDA: 通过直接分析推断	17363900	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	20133940	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	20133940	GOA
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex	IPI IPI: 通过物理相互作用推断	12006501	GOA
colocalizes with mitotic spindle pole	IDA IDA: 通过直接分析推断	22351768	GOA
colocalizes with nuclear envelope	IDA IDA: 通过直接分析推断	22351768	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	22493223	GOA
part of nuclear pore nuclear basket	IDA IDA: 通过直接分析推断	18981471	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19010891	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAD1L1 蛋白结构

MAD

0
200
400
600
718 a.a.

蛋白主名

其他名称

mitotic spindle assembly checkpoint protein MAD1

MAD1 mitotic arrest deficient like 1

MAD1L1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAD1L1	Q9Y6D9	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	TPM3	Homo sapiens	Q5VU62	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	LGALSL	Homo sapiens	Q3ZCW2	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	TSC22D3	Homo sapiens	Q99576-3	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	YJU2	Homo sapiens	Q9BW85	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	YJU2	Homo sapiens	Q9BW85	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	USP15	Homo sapiens	Q9Y4E8	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	USP15	Homo sapiens	Q9Y4E8	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	MFAP1	Homo sapiens	P55081	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	TPR	Homo sapiens	P12270	Anti Bait CoIP	24581499
Intra	MAD1L1	Q9Y6D9	CENPE	Homo sapiens	Q02224	Pull Down	26258632
Intra	MAD1L1	Q9Y6D9	CENPE	Homo sapiens	Q02224	Anti Bait CoIP	26258632
Intra	MAD1L1	Q9Y6D9	CAPN7	Homo sapiens	Q9Y6W3	Validated Y2H	32296183
Intra	MAD1L1	Q9Y6D9	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	NEBL	Homo sapiens	O76041	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	NEBL	Homo sapiens	O76041	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	NEBL	Homo sapiens	O76041	Y2H Array	31515488
Intra	MAD1L1	Q9Y6D9	NEBL	Homo sapiens	O76041	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	TPM3	Homo sapiens	P06753	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	BAG5	Homo sapiens	Q9UL15	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	RNF8	Homo sapiens	O76064	Y2H Array	31515488
Intra	MAD1L1	Q9Y6D9	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	TRIM29	Homo sapiens	Q14134	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	TRIM29	Homo sapiens	Q14134	Y2H Pooling	16189514
Intra	MAD1L1	Q9Y6D9	TRIM29	Homo sapiens	Q14134	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	ZSCAN32	Homo sapiens	Q9NX65	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	ZSCAN32	Homo sapiens	Q9NX65	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	ZSCAN32	Homo sapiens	Q9NX65	Y2H Array	25416956
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	21772247
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	NMR	18318601
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	GMS	18318601
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Lumier	37398436
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	IF	21772247
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	BRET	37398436
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	22493223
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Y2H	21988832
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Y2H Array	31515488
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	24581499
Intra	MAD1L1	Q9Y6D9	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	26258632
Intra	MAD1L1	Q9Y6D9	ALOX5	Homo sapiens	P09917	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	ALOX5	Homo sapiens	P09917	Validated Y2H	25416956
Intra	MAD1L1	Q9Y6D9	TSHZ3	Homo sapiens	Q63HK5	Y2H Prey Pooling	25416956
Intra	MAD1L1	Q9Y6D9	TSHZ3	Homo sapiens	Q63HK5	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Retroperitoneum Carcinoma

Retroperitoneal Cancer	Malignant Neoplasm Of Retroperitoneum And Peritoneum
Retroperitoneal Neoplasms	Carcinoma Of Retroperitoneum
Carcinoma Of The Retroperitoneum	Malignant Neoplasm Of Retroperitoneum
Malignant Retroperitoneal Cancer	Malignant Tumor Of Peritoneum And Retroperitoneum
Neoplasm Of Retroperitoneum	Neoplasm Of The Retroperitoneum
Retroperitoneal Neoplasm	Tumor Of Retroperitoneum
Malignant Retroperitoneal Tumour	Primary Malignant Neoplasm Of Retroperitoneum
Retroperitoneum Cancer

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07948	MAD1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MAD1L1	VGNC	VGNC:74471
Bos taurus	MAD1L1	VGNC	VGNC:31130
Canis familiaris	MAD1L1	VGNC	VGNC:42914
Mus musculus	MAD1L1	MGD	MGI:1341857
Rattus norvegicus	MAD1L1	RGD	RGD:1596881
Felis catus	MAD1L1	VGNC	VGNC:68124

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