2. Gene
  3. BAG5 - BAG cochaperone 5 Gene

BAG5 - BAG cochaperone 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BAG 辅伴侣 5

种属: Homo sapiens

同用名: BAG-5; CMD2F

基因 ID: 9529 | 基因类型: protein coding

关于 BAG5

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,556,551-103,562,657 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 41.2), thyroid (RPKM 15.2) and 24 other tissues.

功能概要

该基因编码的蛋白质是 BAG1 相关蛋白质家族的成员。 BAG1 是一种抗凋亡蛋白，通过与多种细胞凋亡和生长相关蛋白相互作用发挥作用，包括 BCL-2、Raf 蛋白激酶、类固醇激素受体、生长因子受体和热休克蛋白 70 kDa 家族成员。该蛋白在 C 端附近包含一个 BAG 结构域，可以结合并抑制 Hsc70/HSP70 的分子伴侣活性。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG5 基因产物(3)

mRNA Protein Name
NM_001015048.3 NP_001015048.1 BAG family molecular chaperone regulator 5
NM_001015049.5 NP_001015049.2 BAG family molecular chaperone regulator 5
NM_004873.4 NP_004864.1 BAG family molecular chaperone regulator 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24510904 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
24475098 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
15603737 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24270810 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
24510904 GOA
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
24510904 GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
24475098 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
24475098 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
25006867 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
24475098 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
25006867 GOA
involved in regulation of inclusion body assembly IMP
IMP: 通过突变表型推断
15603737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
24510904 GOA
located in inclusion body IDA
IDA: 通过直接分析推断
15603737 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
24475098 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24510904 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15603737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BAG5 蛋白结构

BAG

BAG: BAG domain (13 - 85)

BAG

BAG: BAG domain (185 - 258)

BAG

BAG: BAG domain (278 - 349)

BAG

BAG: BAG domain (369 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
蛋白主名 其他名称

BAG family molecular chaperone regulator 5

BCL2 associated athanogene 5

BAG5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BAG5 Q9UL15 LRRK1 Homo sapiens Q38SD2
Protein Array
24947832
Intra BAG5 Q9UL15 DES Homo sapiens P17661
Y2H Array
32296183
Intra BAG5 Q9UL15 DES Homo sapiens P17661
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra BAG5 Q9UL15 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra BAG5 Q9UL15 TOM1 Homo sapiens O60784-2
Y2H Array
32296183
Intra BAG5 Q9UL15 TOM1 Homo sapiens O60784-2
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 LRRK2 Homo sapiens Q5S007
Pull Down
24510904
Intra BAG5 Q9UL15 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24510904
Intra BAG5 Q9UL15 HSPA1A Homo sapiens P08107
Anti Tag CoIP
24510904
Intra BAG5 Q9UL15 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra BAG5 Q9UL15 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra BAG5 Q9UL15 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra BAG5 Q9UL15 FAM118B Homo sapiens Q9BPY3
Y2H Array
25416956
Intra BAG5 Q9UL15 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra BAG5 Q9UL15 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra BAG5 Q9UL15 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Anti Tag CoIP
25036637
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Anti Tag CoIP
33961781
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
25416956
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
25416956
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra BAG5 Q9UL15 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra BAG5 Q9UL15 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra BAG5 Q9UL15 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra BAG5 Q9UL15 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra BAG5 Q9UL15 q53fc7_human Homo sapiens Q53FC7
Lumier
25036637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Dilated, 2f

CMD2F

Dilated Cardiomyopathy 2f

Cardiomyopathy, Dilated 2f
Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01346 BAG5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BAG5 VGNC VGNC:26409
Canis familiaris BAG5 VGNC VGNC:38367
Rattus norvegicus BAG5 RGD RGD:1310847
Macaca mulatta BAG5 VGNC VGNC:70221
Felis catus BAG5 VGNC VGNC:81031
Mus musculus BAG5 MGD MGI:1917619
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