2. Gene
  3. TPR - translocated promoter region, nuclear basket protein Gene

TPR - translocated promoter region, nuclear basket protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：易位启动子区，核篮蛋白

种属: Homo sapiens

基因 ID: 7175 | 基因类型: protein coding

关于 TPR

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,311,652-186,375,253 (from NCBI)

This gene has 9 transcripts (splice variants), 277 orthologues and is associated with 94 phenotypes. Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues.

功能概要

该基因编码一种大的卷曲螺旋蛋白，该蛋白形成附着在核孔复合体 (NPC) 内表面的核内细丝。该蛋白质直接与 NPC 的几个组件相互作用。它是 mRNA 和一些蛋白质的核输出所必需的。该基因的 5' 端与几种不同的激酶基因发生致癌融合，发生在一些瘤形成中。[RefSeq 提供，2008 年 7 月]

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

TPR 基因产物(1)

mRNA Protein Name
NM_003292.3 NP_003283.2 nucleoprotein TPR
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
17897941 GOA
enables dynein complex binding IDA
IDA: 通过直接分析推断
20133940 GOA
enables heat shock protein binding IDA
IDA: 通过直接分析推断
17897941 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
17897941 GOA
enables mitogen-activated protein kinase binding IDA
IDA: 通过直接分析推断
18794356 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12802065 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11514627 GOA
NOT enables protein-membrane adaptor activity IMP
IMP: 通过突变表型推断
12802065 GOA
enables structural constituent of nuclear pore IDA
IDA: 通过直接分析推断
22253824 GOA
enables tubulin binding IDA
IDA: 通过直接分析推断
20133940 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA export from nucleus IMP
IMP: 通过突变表型推断
11952838 GOA
involved in RNA import into nucleus IDA
IDA: 通过直接分析推断
9864356 GOA
involved in cellular response to heat IDA
IDA: 通过直接分析推断
17897941 GOA
involved in mRNA export from nucleus in response to heat stress IDA
IDA: 通过直接分析推断
17897941 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
20133940 GOA
involved in negative regulation of RNA export from nucleus IDA
IDA: 通过直接分析推断
22253824 GOA
involved in negative regulation of RNA export from nucleus IMP
IMP: 通过突变表型推断
21613532 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21613532 GOA
involved in negative regulation of translational initiation IMP
IMP: 通过突变表型推断
21613532 GOA
NOT involved in nuclear matrix organization IMP
IMP: 通过突变表型推断
11952838 GOA
NOT involved in nuclear pore complex assembly IMP
IMP: 通过突变表型推断
12802065 GOA
NOT involved in nuclear pore organization IMP
IMP: 通过突变表型推断
11952838 GOA
involved in nuclear pore organization IMP
IMP: 通过突变表型推断
15229283 GOA
involved in positive regulation of heterochromatin formation IMP
IMP: 通过突变表型推断
20407419 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: 通过突变表型推断
19273613 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: 通过突变表型推断
18981471 GOA
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
18794356 GOA
NOT involved in protein export from nucleus IMP
IMP: 通过突变表型推断
11952838 GOA
NOT involved in protein import into nucleus IDA
IDA: 通过直接分析推断
9864356 GOA
NOT involved in protein import into nucleus IMP
IMP: 通过突变表型推断
11952838 GOA
involved in protein import into nucleus IMP
IMP: 通过突变表型推断
18794356 GOA
NOT involved in regulation of mRNA export from nucleus IMP
IMP: 通过突变表型推断
22253824 GOA
involved in regulation of mitotic sister chromatid separation IMP
IMP: 通过突变表型推断
20133940 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
19273613 GOA
NOT involved in regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
22253824 GOA
NOT involved in regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
22253824 GOA
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
18981471 GOA
NOT involved in regulation of protein stability IMP
IMP: 通过突变表型推断
21613532 GOA
involved in response to epidermal growth factor IDA
IDA: 通过直接分析推断
18794356 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11952838 GOA
part of cytoplasmic dynein complex IDA
IDA: 通过直接分析推断
20133940 GOA
NOT located in kinetochore IDA
IDA: 通过直接分析推断
19273613 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
20133940 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
20133940 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
17098863 GOA
located in nuclear inclusion body IDA
IDA: 通过直接分析推断
11514627 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
9024684 GOA
located in nuclear periphery IDA
IDA: 通过直接分析推断
9024684 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
9828100 GOA
part of nuclear pore nuclear basket IDA
IDA: 通过直接分析推断
9024684 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15654337 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPR 蛋白结构

TPR_MLP1_2

TPR_MLP1_2: TPR/MLP1/MLP2-like protein (1037 - 1167)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2363 a.a.
蛋白主名 其他名称

nucleoprotein TPR

NPC-associated intranuclear protein

TPR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TPR P12270 MAD1L1 Homo sapiens Q9Y6D9
Pull Down
24581499
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome

Arthropathy-Camptodactyly Syndrome

Pericarditis-Arthropathy-Camptodactyly Syndrome

Xyy Syndrome

Pac Syndrome

Cacp Syndrome

CACP

Fibrosing Serositis, Familial

Camptodactyly-Arthropathy-Pericarditis Syndrome

Cap Syndrome

47, Xyy Syndrome

47,Xyy Syndrome

Double Y Syndrome

Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

Hypertrophic Synovitis, Congenital Familial

Congenital Familial Hypertrophic Synovitis

Xyy Karyotype

Y Disomy

Yy Syndrome

Familial Fibrosing Serositis

Disomy Y

Double Y

Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

Arthropathy Camptodactyly Syndrome

Camptodactyly Arthropathy Pericarditis Syndrome

Pericarditis Arthropathy Camptodactyly Syndrome

Jacob'S Syndrome

47,Xyy

Cdags Syndrome
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Bejel

Njovera

Dichuchwa

Nonvenereal Endemic Syphilis

Endemic Syphilis

Frenga

Nonvenereal Syphilis

Treponemal Infections

Non-Venereal Endemic Syphilis

Siti

Skerljevo

Belesh
Yaws

Frambesia

Frambesia Tropica

Bouba

Frambosie

Polypapilloma Tropicum

Thymosis

Endemic Treponematoses

Treponema Pertenue Infection

Pian

Framboesia

Framboesia Tropica

Castellani

Infection By Treponema Pertenue

Parangi

Framboesioma

Chancre Of Yaws

Primary Framboesia

Initial Lesions Of Yaws

Mother Yaw

Initial Framboesia
Primary Syphilis

Early Symptomatic Syphilis

Early Syphilis, Symptomatic

Symptomatic Early Syphilis
Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone
Latent Syphilis

Syphilis, Latent
Late Yaws

Yaws Gummata And Ulcers

Gummata And Ulcers Due To Yaws

Gummata Of Yaws

Gummatous Frambeside

Multiple Papillomata Due To Yaws And Wet Crab Yaws

Nodular Late Yaws

Ulcers Of Yaws
Gummatous Syphilis
Early Yaws

Initial Lesions Of Yaws

Bone And Joint Lesions Due To Yaws

Bone And Joint Yaws Lesion

Chancre Of Yaws

Frambesia, Initial Or Primary

Initial Frambesial Ulcer

Primary Frambesia

Initial Lesion Of Yaws
Early Congenital Syphilis
Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe

Malignant Neoplasm Of Occipital Lobe

Tumor Of Occipital Lobe
Congenital Syphilis

Syphilis, Congenital

Congenital Syphilis, Unspecified

Mtct Of Syphilis

Mother-To-Child Transmission Of Syphilis

Syphilis Congenital

Hereditary Syphilis

Heredosyphilis
Cardiovascular Syphilis

Syphilis, Cardiovascular
Acute Pericementitis

Acute Periodontitis

Aggressive And Acute Periodontitis

Peridental Infection

Periodontal Infection
Meningovascular Neurosyphilis
Tertiary Syphilis

Late Syphilis

Syphilis, Tertiary

Late Syphilis, Unspecified

Late Tertiary Syphilis
Tertiary Neurosyphilis

Late Neurosyphilis

Late Syphilis Of Central Nervous System Nos
Pulp Degeneration

Degeneration Of Dental Pulp
Parenchymatous Neurosyphilis
Syphilis

Chancre

Syphilitic Chancre
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Childhood Hepatocellular Carcinoma

Pediatric Hepatocellular Carcinoma

Childhood Carcinoma Of Liver Cell

Childhood Hepatoma

Childhood Liver Cell Carcinoma

Pediatric Carcinoma Of Liver Cell

Pediatric Hepatoma

Pediatric Liver Cell Carcinoma

Childhood-Onset Hcc

Childhood-Onset Hepatocellular Carcinoma

Pediatric Hcc

Childhood Liver Cancer
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103241 Ro 90-7501 99.10% 否
HY-125759 3-Phenyltoxoflavin Inhibitor 99.86% 否
HY-P1896 Hsp70-derived octapeptide 98.01% 否
HY-RS14946 TPR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TPR VGNC VGNC:100164
Mus musculus TPR MGD MGI:1922066
Rattus norvegicus TPR RGD RGD:1310664
Felis catus TPR VGNC VGNC:107957
Canis familiaris TPR VGNC VGNC:53807
Others TPR NCBI
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