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  2. TSHZ3 - teashirt zinc finger homeobox 3 Gene

TSHZ3 - teashirt zinc finger homeobox 3 Gene

中文名称:teashirt 锌指同源盒 3

种属: Homo sapiens

同用名: TSH3; ZNF537

基因 ID: 57616 | 基因类型: protein coding

关于 TSHZ3

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:31,149,876-31,350,877 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in ovary (RPKM 16.6), endometrium (RPKM 15.6) and 19 other tissues.

功能概要

该基因编码一种锌指转录因子,可调节发育中泌尿道中的平滑肌细胞分化。与这一作用一致,该基因失活的小鼠在尿路平滑肌细胞前体和肾脏缺陷 (包括肾积水) 中表现出异常基因表达。编码的转录因子包含抑制半胱天冬酶表达的基因沉默复合物。该基因表达减少和随后的半胱天冬酶上调可能与人类患者阿尔茨海默氏病的进展相关。[RefSeq 提供,2016 年 7 月]

This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits Caspase expression. Reduced expression of this gene and consequent Caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]

TSHZ3 基因产物(1)

mRNA Protein Name
NM_020856.4 NP_065907.2 teashirt homolog 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
19343227 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19343227 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19343227 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19343227 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TSHZ3 蛋白结构

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (213 - 245)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (272 - 301)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (386 - 412)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1041 - 1064)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1081 a.a.
蛋白主名 其他名称

teashirt homolog 3

teashirt family zinc finger 3

TSHZ3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TSHZ3 Q63HK5 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra TSHZ3 Q63HK5 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 CTBP1 Homo sapiens Q13363-2
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra TSHZ3 Q63HK5 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra TSHZ3 Q63HK5 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 ANKRA2 Homo sapiens Q9H9E1
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 ANKRA2 Homo sapiens Q9H9E1
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 ANKRA2 Homo sapiens Q9H9E1
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra TSHZ3 Q63HK5 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra TSHZ3 Q63HK5 LRRC73 Homo sapiens Q5JTD7
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 LRRC73 Homo sapiens Q5JTD7
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra TSHZ3 Q63HK5 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra TSHZ3 Q63HK5 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra TSHZ3 Q63HK5 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 SPAG5 Homo sapiens Q96R06
Y2H Array
25416956
Intra TSHZ3 Q63HK5 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra TSHZ3 Q63HK5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra TSHZ3 Q63HK5 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 MRPL28 Homo sapiens Q13084
Y2H Array
32296183
Intra TSHZ3 Q63HK5 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra TSHZ3 Q63HK5 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra TSHZ3 Q63HK5 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 CEP63 Homo sapiens Q96MT8
Y2H Prey Pooling
25416956
Intra TSHZ3 Q63HK5 CEP63 Homo sapiens Q96MT8
Y2H Array
25416956
Intra TSHZ3 Q63HK5 APEX2 Homo sapiens Q9UBZ4
Y2H Prey Pooling
32296183
Intra TSHZ3 Q63HK5 APEX2 Homo sapiens Q9UBZ4
Validated Y2H
32296183
Intra TSHZ3 Q63HK5 APEX2 Homo sapiens Q9UBZ4
Y2H Array
32296183
Intra TSHZ3 Q63HK5 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra TSHZ3 Q63HK5 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra TSHZ3 Q63HK5 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra TSHZ3 Q63HK5 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Prune Belly Syndrome

Eagle-Barrett Syndrome

Abdominal Muscle Deficiency Syndrome

PBS

Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism

Egbrs

Eagle-Barret Syndrome

Urethral Obstruction Sequence

Obrinsky Syndrome

Triad Syndrome

Obrisnksy Syndrome

Euos

Early Urethral Obstruction Sequence

Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction

Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism

Abdomen Muscle Deficiency Syndrome

Abdomen Muscular Deficiency Syndrome

Abdominal Muscular Deficiency Syndrome

Abdominal Muscle Aplasia Syndrome

Calvarial Doughnut Lesions With Bone Fragility

Calvarial Doughnut Lesions With Bone Fragility With Or Without Spondylometaphyseal Dysplasia

Calvarial Doughnut Lesions-Bone Fragility Syndrome

CDL

Doughnut Lesions Of Skull, Familial

Calvarial Doughnut Lesions With Bone Fragility And Spondylometaphyseal Dysplasia

Familial Doughnut Lesions Of Skull

CDLSMD

Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases

Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TSHZ3 VGNC VGNC:47905
Mus musculus TSHZ3 MGD MGI:2442819
Felis catus TSHZ3 VGNC VGNC:66619
Rattus norvegicus TSHZ3 RGD RGD:1306322
Macaca mulatta TSHZ3 VGNC VGNC:79866
Bos taurus TSHZ3 VGNC VGNC:36420