2. Gene
  3. ANKRA2 - ankyrin repeat family A member 2 Gene

ANKRA2 - ankyrin repeat family A member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锚蛋白重复家族 A 成员 2

种属: Homo sapiens

同用名: ANKRA

基因 ID: 57763 | 基因类型: protein coding

关于 ANKRA2

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,552,190-73,565,639 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 11.0), endometrium (RPKM 9.3) and 25 other tissues.

功能概要

具有酶结合活性和低密度脂蛋白颗粒受体结合活性。参与调节含蛋白质的复合物装配。位于胞质溶胶和膜中。部分含蛋白质复合物。与 3M 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in cytosol and membrane. Part of protein-containing complex. Colocalizes with 3M complex. [provided by Alliance of Genome Resources, Apr 2022]

ANKRA2 基因产物(1)

mRNA Protein Name
NM_023039.5 NP_075526.1 ankyrin repeat family A protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone deacetylase binding IDA
IDA: 通过直接分析推断
22649097 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
22649097 GOA
enables low-density lipoprotein particle receptor binding IPI
IPI: 通过物理相互作用推断
22649097 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20873783 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
25752541 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
25752541 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of 3M complex IDA
IDA: 通过直接分析推断
25752541 GOA
located in cytosol IDA
IDA: 通过直接分析推断
11095640 GOA
located in membrane IDA
IDA: 通过直接分析推断
11095640 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
20873783 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANKRA2 蛋白结构

Ank

Ank: Ankyrin repeat (182 - 209)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (216 - 276)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

ankyrin repeat family A protein 2

RFXANK-like protein 2

ANKRA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANKRA2 Q9H9E1 SAMD4A Homo sapiens Q9UPU9-3
Validated Y2H
32296183
种属内
ANKRA2 Q9H9E1 RFX7 Homo sapiens Q2KHR2
X-Ray Diffraction
31864703
种属内
ANKRA2 Q9H9E1 RFX7 Homo sapiens Q2KHR2
Anti Tag CoIP
25752541
种属内
ANKRA2 Q9H9E1 HDAC4 Homo sapiens P56524
Validated Y2H
25416956
种属内
ANKRA2 Q9H9E1 HDAC4 Homo sapiens P56524
Y2H Array
25416956
种属内
ANKRA2 Q9H9E1 HDAC4 Homo sapiens P56524
Y2H Prey Pooling
25416956
种属内
ANKRA2 Q9H9E1 CCDC8 Homo sapiens Q9H0W5
Anti Tag CoIP
25752541
种属内
ANKRA2 Q9H9E1 HDAC5 Homo sapiens Q9UQL6
Anti Tag CoIP
25752541
种属内
ANKRA2 Q9H9E1 HDAC5 Homo sapiens Q9UQL6
Phage Display
35044719
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae
Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome

BOFS

Bof Syndrome

Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome

Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome

Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging

Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging

Bofs Syndrome

Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00711 ANKRA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ANKRA2 VGNC VGNC:37879
Felis catus ANKRA2 VGNC VGNC:59795
Rattus norvegicus ANKRA2 RGD RGD:1303108
Mus musculus ANKRA2 MGD MGI:1915808
Bos taurus ANKRA2 VGNC VGNC:25907
Macaca mulatta ANKRA2 VGNC VGNC:69603
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