HDAC5 - histone deacetylase 5 Gene

中文名称：组蛋白脱乙酰酶 5

种属: Homo sapiens

同用名: HD5; NY-CO-9

基因 ID: 10014 | 基因类型: protein coding

关于 HDAC5

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,076,753-44,123,641 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 14.0), ovary (RPKM 13.4) and 25 other tissues.

功能概要

组蛋白在转录调控、细胞周期进程和发育事件中发挥关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对 DNA 的访问。该基因编码的蛋白质属于 II 类组蛋白脱乙酰酶/acuc/apha 家族。它具有组蛋白脱乙酰酶活性，并在连接到启动子时抑制转录。它仅与 HDAC3 家族成员共免疫沉淀，并可能形成复合蛋白。它还与肌细胞增强因子 2 (MEF2) 蛋白相互作用，从而抑制 MEF2 依赖性基因。该基因被认为与结肠癌有关。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon Cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC5 基因产物(16)

mRNA	Protein	Name
XM_047435054.1	XP_047291010.1	histone deacetylase 5 isoform X7
NM_001382393.1	NP_001369322.1	histone deacetylase 5 isoform 1
XM_047435048.1	XP_047291004.1	histone deacetylase 5 isoform X2
NM_139205.1
XM_047435051.1	XP_047291007.1	histone deacetylase 5 isoform X3
NM_005474.5	NP_005465.2	histone deacetylase 5 isoform 1
XM_047435055.1	XP_047291011.1	histone deacetylase 5 isoform X8
XM_011524149.3	XP_011522451.1	histone deacetylase 5 isoform X4
XM_047435053.1	XP_047291009.1	histone deacetylase 5 isoform X6
NM_001015053.2	NP_001015053.1	histone deacetylase 5 isoform 3
XM_047435052.1	XP_047291008.1	histone deacetylase 5 isoform X5
XM_047435050.1	XP_047291006.1	histone deacetylase 5 isoform X3
XM_047435049.1	XP_047291005.1	histone deacetylase 5 isoform X2
XM_047435047.1	XP_047291003.1	histone deacetylase 5 isoform X1
XM_047435056.1	XP_047291012.1	histone deacetylase 5 isoform X8
XM_047435057.1	XP_047291013.1	histone deacetylase 5 isoform X9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	12242305	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	24413532	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	19071119	GOA
enables histone deacetylase activity	IDA IDA: 通过直接分析推断	10869435	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	23867755	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10869435	GOA
enables protein kinase C binding	IPI IPI: 通过物理相互作用推断	20188095	GOA
enables protein lysine deacetylase activity	IMP IMP: 通过突变表型推断	23867755	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19351956	GOA
enables transcription corepressor binding	IPI IPI: 通过物理相互作用推断	10898795	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	19351956	GOA
involved in negative regulation of myotube differentiation	IMP IMP: 通过突变表型推断	10983972	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16236793	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10869435	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10983972	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	19071119	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	19071119	GOA
involved in regulation of protein binding	IMP IMP: 通过突变表型推断	19071119	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10869435	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10869435	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC5 蛋白结构

HDAC4_Gln

Hist_deacetyl

0
200
400
600
800
1000
1122 a.a.

蛋白主名

其他名称

histone deacetylase 5

antigen NY-CO-9

关联疾病

疾病名称

别名

Alzheimer Disease 19

AD19	Alzheimer'S Disease 19
Alzheimer Disease 19, Late-Onset	Alzheimer Disease 19 Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Late Onset, Susceptibility To, Type 19
Alzheimer Disease, Late Onset

Anhidrosis, Isolated, With Normal Sweat Glands

Isolated Anhidrosis With Normal Sweat Glands	Dann-Epstein-Sohar Syndrome
ANHD	Isolated Generalized Anhidrosis With Normal Sweat Glands
Anhidrosis, Familial Generalized, With Normal Sweat Glands

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-13322	Pracinostat	Inhibitor	99.82%	是

目录号	产品名	作用方式	纯度	Phase
HY-14842	Givinostat	Inhibitor	98.16%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.28%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	98.84%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-18361	TMP195	Inhibitor	99.57%	否
HY-18998	LMK-235	Inhibitor	99.61%	否
HY-13428	Tubacin	Inhibitor	99.54%	否
HY-18360	TMP269	Inhibitor	98.05%	否
HY-16699	Nexturastat A	Inhibitor	98.28%	否
HY-112719	BRD 4354	Inhibitor	99.66%	否
HY-119939	CHDI-390576	Inhibitor	98.07%	否
HY-115475	SW-100	Inhibitor	99.59%	否
HY-143248	KR-39038	Inhibitor	99.48%	否
HY-126330	SS-208	Inhibitor	99.00%	否
HY-149285	NT160	Inhibitor	99.58%	否
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	否
HY-117554	BRD9757	Inhibitor	99.75%	否
HY-146678	HDAC6-IN-5	Inhibitor	/	否
HY-150109	Purinostat mesylate	Inhibitor	/	否
HY-146679	HDAC6-IN-6	Inhibitor	/	否
HY-161778	ZG-126	Inhibitor	/	否
HY-152226	MC2590	Inhibitor	/	否
HY-149208	HDAC-IN-53	Inhibitor	/	否
HY-15144B	(S)-Trichostatin A	Inhibitor	/	否
HY-146351	HDAC-IN-38	Inhibitor	/	否
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	否
HY-163803	CM-444	Inhibitor	/	否
HY-150595	HDAC6-IN-10	Inhibitor	/	否
HY-147934	HDAC8-IN-3	Inhibitor	/	否
HY-152225	MC2625	Inhibitor	/	否
HY-157740	XSJ-10	Inhibitor	/	否
HY-146684	HDAC-IN-36	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HDAC5	VGNC	VGNC:49093
Macaca mulatta	HDAC5	VGNC	VGNC:73166
Felis catus	HDAC5	VGNC	VGNC:62768
Mus musculus	HDAC5	MGD	MGI:1333784
Rattus norvegicus	HDAC5	RGD	RGD:619980
Bos taurus	HDAC5	VGNC	VGNC:50612

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