2. Cell Cycle/DNA Damage Epigenetics Autophagy Apoptosis
  3. HDAC Autophagy Apoptosis
  4. HDAC-IN-36

HDAC-IN-36 (compound 23 g) 是一种口服有效的HDAC (组蛋白去乙酰化酶)抑制剂，其 IC50 为 11.68 nM (HDAC6)。HDAC-IN-36 可促进细胞凋亡 (apoptosis)，自噬 (autophagy) 和抑制迁移。HDAC-IN-36 具有抗肿瘤和抗转移活性，可用于乳腺癌研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

HDAC-IN-36 Chemical Structure

HDAC-IN-36 Chemical Structure

CAS No. : 2482992-54-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC-IN-36 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-36 (compound 23 g) is an orally active and potent HDAC (histone deacetylase) inhibitor, with an IC50 of 11.68 nM (HDAC6). HDAC-IN-36 promotes apoptosis, autophagy and suppresses migration. HDAC-IN-36 shows anti-tumor and anti-metastatic activity, and can be used for breast cancer research[1].

IC50 & Target

HDAC6

11.68 nM (IC50)

HDAC10

13.24 nM (IC50)

HDAC3

79.17 nM (IC50)

HDAC1

86.93 nM (IC50)

HDAC2

97.32 nM (IC50)

HDAC8

378.2 nM (IC50)

HDAC4

>1000 nM (IC50)

HDAC5

>1000 nM (IC50)

HDAC7

>1000 nM (IC50)

HDAC9

>1000 nM (IC50)

HDAC11

>1000 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-36 (compound 23 g) (0-10, 24 h) exhibits good antiproliferative activity in MDA-MB-231 cells, promotes the acetylation of α-Tubulin and HSP90[1].
HDAC-IN-36 (0-10, 24 h) induces apoptosis in MDA-MB-231 cells in a dose-dependent manner, and mainly induces mitochondrial-dependent apoptosis[1].
HDAC-IN-36 (0-10, 24 h) inhibits MDA-MB-231 cells migration in a dose-dependent manner, increases the expression of E-cadherin and decreases the expression of MMP-2 obviously[1].
HDAC-IN-36 (0-10, 24 h) induces noteworthy autophagy, increases the expression of Beclin1, LC3II and decreases the expression of SQSTM1/p62[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-36 相关抗体:

Cell Viability Assay

Cell Line: MDA-MB-231 cells[1]
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Exhibited good anti-proliferative activity in MDA-MB-231 cells, with IC50 of 1.32 ± 0.13 μM, increased the acetylation level of intracellular proteins, and promoted the acetylation of α-Tubulin and HSP90.

Apoptosis Analysis

Cell Line: MDA-MB-231 cells[1]
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-231 cells in a dose-dependent manner.

Cell Autophagy Assay

Cell Line: MDA-MB-231 cells[1]
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Induced noteworthy autophagy with increased aggregation of LC3 puncta.

Western Blot Analysis

Cell Line: MDA-MB-231 cells[1]
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Mainly induced mitochondrial-dependent apoptosis, up-regulated the expression of Bax and downregulated the expression of Bcl-2, and increased the cleavage of caspase3, caspase8 and caspase9; increased the expression of E-cadherin and decreased the expression of MMP-2 obviously; increased the expression of Beclin1, LC3II and decreased the expression of SQSTM1/p62.
体内研究
(In Vivo)

HDAC-IN-36 (compound 23 g) (Zebrafish tumor xenograft model; 0-5 μg/mL, 3 days) shows potent anti-tumor and anti-metastatic activity, and improves in vivo anti-tumor efficacy[1].
HDAC-IN-36 (Beagles, 20 mg/kg, Orally, once) shows a significant improvement in pharmacokinetic parameters[1].
Pharmacokinetic Parameters of HDAC-IN-36 in male Beagles[1].

Parameters 23g (20 mg/kg)
T1/2 (h) 1.24 ± 0.21
Tmax (h) 0.79 ± 0.33
Cmax (μg/L) 120.36 ± 15.53
AUC0-t (μg/L∗h) 1275.35 ± 70.17
AUC0-∞ (μg/L∗h) 1289.40 ± 88.91

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish (MDA-MB-231-derived xenograft model, Wild-type AB strain)[1]
Dosage: 0, 2.5, 5 μg/mL
Administration: 3 days
Result: Inhibited tumor formation and migration in a dose-dependent manner, and improved in vivo anti-tumor efficacy.
Animal Model: Beagles (female, 8-10 kg, n = 4)[1]
Dosage: 20 mg/kg (dissolved 0.5% sodium carboxyl methyl cellulose (CMC-Na) aqueous solution)
Administration: Orally, once (Pharmacokinetic Analysis)
Result: Showed a significant improvement in pharmacokinetic parameters with T1/2 value of 1.24 h.
分子量

537.65

Formula

C29H39N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-362482992-54-9HDACAutophagyApoptosisHistone deacetylasesBreast cancerOrally activeMDA-MB-231 cellAnti-tumor activityInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC-IN-36
目录号：
HY-146684
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z