2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. HDAC Microtubule/Tubulin
  4. HDAC6-IN-10

HDAC6-IN-10 是一种高选择性的 HDAC6 抑制剂，IC50 为 0.73 nM，对其他 HDAC 异构体有 144~10941 倍的选择性。HDAC6-IN-10 对多发性骨髓瘤细胞表现出抗增殖活性。

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HDAC6-IN-10 Chemical Structure

HDAC6-IN-10 Chemical Structure

CAS No. : 2408286-73-5

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HDAC6-IN-10 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1].

IC50 & Target[1]

HDAC6

0.73 nM (IC50)

HDAC10

105 nM (IC50)

HDAC8

513 nM (IC50)

HDAC7

752 nM (IC50)

HDAC11

1800 nM (IC50)

HDAC9

2560 nM (IC50)

HDAC5

4370 nM (IC50)

HDAC4

5620 nM (IC50)

HDAC1

8020 nM (IC50)

体外研究
(In Vitro)

HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6[1].
HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-10 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 hours
Result: Showed a dose-dependent increase in the level of Ac-tubulin.

Cell Proliferation Assay[1]

Cell Line: RPMI-8226 and U266 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed antiproliferative activities against RPMI-8226 and U266 with the IC50s of 33.183 μM and 43.233 μM, respectively.
分子量

392.41

Formula

C21H20N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-102408286-73-5HDACMicrotubule/TubulinHistone deacetylasesHCT-116RPMI-8226U266anti-proliferative activityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150595
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