2. Cell Cycle/DNA Damage Epigenetics Vitamin D Related/Nuclear Receptor
  3. HDAC VD/VDR
  4. ZG-126

ZG-126 是维生素 D 受体 (VDR) 的激动剂和组蛋白去乙酰化酶 (HDAC) 的抑制剂 (IC50=0.63-67.6 μM)。ZG-126 在癌细胞 MDA-MB-231 和 4T1 中表现出细胞毒性。ZG-126 在小鼠模型中对黑色素瘤和三阴性乳腺癌 (TNBC) 表现出抗肿瘤和抗转移活性。ZG-126 通过减少巨噬细胞浸润和免疫抑制性亚型 M2 极化表现出抗炎活性。

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ZG-126 Chemical Structure

ZG-126 Chemical Structure

CAS No. : 3049802-32-3

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ZG-126 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization[1].

IC50 & Target

HDAC6

0.633 μM (IC50)

HDAC3

0.997 μM (IC50)

HDAC11

2.02 μM (IC50)

HDAC1

2.53 μM (IC50)

HDAC8

3.31 μM (IC50)

HDAC2

4.64 μM (IC50)

HDAC10

13.9 μM (IC50)

HDAC7

55.4 μM (IC50)

HDAC5

59.4 μM (IC50)

HDAC4

67.6 μM (IC50)

分子量

513.67

Formula

C29H43N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZG-126 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZG-1263049802-32-3ZG126ZG 126HDACVD/VDRHistone deacetylasesVitamin DVitamin D receptorC57BL/6 mouseB16-F10MDA-MB-2314T1panmelanomaTNBCInhibitorinhibitorinhibit

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产品名称：
ZG-126
目录号：
HY-161778
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