2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Sirtuin Apoptosis
  4. C1A

C1A 是 I/II 类 HDAC 和 sirtuin 抑制剂，对 HDAC6 的 IC50 为 479 nM。C1A 诱导 HDAC6 底物 α-微管蛋白和 HSP90 的持续乙酰化。C1A 表现出很强的抗癌作用，并诱导癌细胞凋亡 (apoptosis)。

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C1A Chemical Structure

C1A Chemical Structure

CAS No. : 1021463-02-4

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Customer Review

C1A 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].

IC50 & Target[1]

HDAC6

0.48 μM (IC50)

HDAC8

0.61 μM (IC50)

HDAC3

5.5 μM (IC50)

HDAC10

9.8 μM (IC50)

HDAC2

11 μM (IC50)

HDAC1

14 μM (IC50)

HDAC5

15 μM (IC50)

HDAC4

16 μM (IC50)

HDAC7

49 μM (IC50)

HDAC9

56 μM (IC50)

SIRT3

55 μM (IC50)

体外研究
(In Vitro)

C1A (0.5-10 μM; 4-24 h) induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90[1].
C1A（2.5-10 μM；24 小时）以药物浓度相关的方式增加亚 G1 群体。C1A 在低微摩尔范围内诱导细胞凋亡并抑制来自不同来源的一组人类肿瘤细胞系的增殖[1]。
C1A（0.5-10 μM；4-24 小时）诱导 HDAC6 底物、α-微管蛋白和 HSP90 的持续乙酰化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C1A 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 2.5 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 24 h
Result: Increased the sub-G1 population in a drug concentration-related manner.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 4 h and 24 h
Result: Induced sustained acetylation of HDAC6 substrates, α-tubulin and HSP90.
体内研究
(In Vivo)

C1A（40 mg/kg；腹腔注射；每天一次、每天两次、每两天一次；持续 14 天）抑制体内结肠肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu-BALB/c mice injected with HCT-116 cells[1]
Dosage: 20 mg/kg, 40 mg/kg
Administration: ip; once a day, twice a day, once every two days; for 14 days
Result: Inhibited the growth of colon tumours in vivo.
分子量

498.42

Formula

C22H25Cl2N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

C1A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C1A1021463-02-4HDACSirtuinApoptosisHistone deacetylasesHDAC6 Inhibitorα-tubulinHSP90apoptosisInhibitorinhibitorinhibit

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产品名称：
C1A
目录号：
HY-124946
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