BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

中文名称：BRMS1 转录抑制因子和失巢凋亡调节因子

种属: Homo sapiens

基因 ID: 25855 | 基因类型: protein coding

关于 BRMS1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,337,339-66,345,104 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues.

功能概要

该基因降低了人乳腺癌和黑色素瘤细胞系的转移潜能，但不降低其致瘤性。由该基因编码的蛋白质主要定位于细胞核，是组蛋白脱乙酰酶复合物 (HDAC) 的 mSin3a 家族的一个组成部分。该蛋白质包含两个卷曲螺旋基序和几个不完美的亮氨酸拉链基序。可变剪接导致编码不同异构体的两个转录变体。[RefSeq 提供，2008 年 7 月]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast Cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

BRMS1 基因产物(2)

mRNA	Protein	Name
NM_001024957.2	NP_001020128.1	breast cancer metastasis-suppressor 1 isoform 2
NM_015399.4	NP_056214.1	breast cancer metastasis-suppressor 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NF-kappaB binding	IDA IDA: 通过直接分析推断	17000776	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16919237	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20830743	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	17000776	GOA
involved in positive regulation of anoikis	IMP IMP: 通过突变表型推断	17000776	GOA
involved in positive regulation of protein deacetylation	IDA IDA: 通过直接分析推断	17000776	GOA
involved in regulation of apoptotic process	IDA IDA: 通过直接分析推断	17000776	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20830743	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17000776	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRMS1 蛋白结构

Sds3

0
100
200
246 a.a.

蛋白主名

其他名称

breast cancer metastasis-suppressor 1

breast cancer metastasis suppressor 1

BRMS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BRMS1	Q9HCU9	DNAJB6	Homo sapiens	O75190	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	DNAJB6	Homo sapiens	O75190	Y2H	16919237
种属内	BRMS1	Q9HCU9	HDAC6	Homo sapiens	Q9UBN7	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	HDAC6	Homo sapiens	Q9UBN7	Anti Tag CoIP	16919237
种属内	BRMS1	Q9HCU9	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
种属内	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	28514442
种属内	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	16919237
种属内	BRMS1	Q9HCU9	HDAC4	Homo sapiens	P56524	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Validated Y2H	25416956
种属内	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Y2H	16919237
种属内	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	25416956
种属内	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	MAPPIT	25416956
种属内	BRMS1	Q9HCU9	SMARCE1	Homo sapiens	Q969G3	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	SMARCE1	Homo sapiens	Q969G3	Anti Tag CoIP	25416956
种属内	BRMS1	Q9HCU9	SUDS3	Homo sapiens	Q9H7L9	Y2H	16919237
种属内	BRMS1	Q9HCU9	SUDS3	Homo sapiens	Q9H7L9	Anti Bait CoIP	16919237
种属内	BRMS1	Q9HCU9	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	16919237
种属内	BRMS1	Q9HCU9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-145946	BRM/BRG1 ATP Inhibitor-2	Inhibitor	99.67%	否
HY-148373	BRM/BRG1 ATP Inhibitor-3	Inhibitor	/	否
HY-148374	BRM/BRG1 ATP Inhibitor-4	Inhibitor	/	否
HY-168242	PROTAC BRM/BRG1 degrader-1	Inhibitor	/	否
HY-RS01626	BRMS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	BRMS1	VGNC	VGNC:60178
Canis familiaris	BRMS1	VGNC	VGNC:54777
Bos taurus	BRMS1	VGNC	VGNC:54781
Rattus norvegicus	BRMS1	RGD	RGD:1311057
Mus musculus	BRMS1	MGD	MGI:2388804
Macaca mulatta	BRMS1	VGNC	VGNC:70334

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

关于 BRMS1

功能概要

BRMS1 基因产物(2)

BRMS1 蛋白结构

BRMS1 蛋白互作信息

关联疾病

直系同源

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BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

关于 BRMS1

功能概要

BRMS1 基因产物(2)

BRMS1 蛋白结构

BRMS1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z