1. Gene
  2. TM4SF4 - transmembrane 4 L six family member 4 Gene

TM4SF4 - transmembrane 4 L six family member 4 Gene

中文名称:跨膜 4 L 六个家族成员 4

种属: Homo sapiens

同用名: ILTMP; il-TMP

基因 ID: 7104 | 基因类型: protein coding

关于 TM4SF4

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,474,697-149,503,394 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员,也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白,其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。这种编码的蛋白质是一种细胞表面糖蛋白,可以调节细胞增殖。[RefSeq 提供,2011 年 3 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF4 基因产物(1)

mRNA Protein Name
NM_004617.4 NP_004608.1 transmembrane 4 L6 family member 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TM4SF4 蛋白结构

L6_membrane

L6_membrane: L6 membrane protein (1 - 192)

  • 0
  • 100
  • 202 a.a.
蛋白主名 其他名称

transmembrane 4 L6 family member 4

intestinal and liver (il) tetraspan membrane protein

关联疾病

疾病名称 别名
Cutis Laxa, Autosomal Dominant 2

ADCL2

Autosomal Dominant Cutis Laxa 2

Cutis Laxa, Autosomal Dominant, 2

Cutis Laxa, Autosomal Dominant, Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TM4SF4 VGNC VGNC:102855
Macaca mulatta TM4SF4 VGNC VGNC:78564
Mus musculus TM4SF4 MGD MGI:2385173
Canis familiaris TM4SF4 VGNC VGNC:47409
Rattus norvegicus TM4SF4 RGD RGD:621784
Bos taurus TM4SF4 VGNC VGNC:35906