2. Gene
  3. KCNK5 - potassium two pore domain channel subfamily K member 5 Gene

KCNK5 - potassium two pore domain channel subfamily K member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钾二孔域通道亚科 K 成员 5

种属: Homo sapiens

同用名: TASK2; K2p5.1; KCNK5b; TASK-2

基因 ID: 8645 | 基因类型: protein coding

关于 KCNK5

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,188,971-39,229,475 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 14 paralogues. Broad expression in small intestine (RPKM 18.5), kidney (RPKM 17.9) and 19 other tissues.

功能概要

该基因编码含有两个成孔 P 结构域的钾通道蛋白超家族成员之一。该基因的信息主要在肾的皮质远端小管和集合管中表达。该蛋白对外部 pH 高度敏感，结合其表达模式表明它可能在肾钾转运中发挥重要作用。[RefSeq 提供，2008 年 7 月]

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

KCNK5 基因产物(1)

mRNA Protein Name
NM_003740.4 NP_003731.1 potassium channel subfamily K member 5

KCNK5 蛋白结构

Ion_trans_2

Ion_trans_2: Ion channel (78 - 137)

Ion_trans_2

Ion_trans_2: Ion channel (170 - 244)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
蛋白主名 其他名称

potassium channel subfamily K member 5

K2P5.1 potassium channel

KCNK5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KCNK5 O95279 TMEM128 Homo sapiens Q5BJH2-2
Validated Y2H
32296183
Intra KCNK5 O95279 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra KCNK5 O95279 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra KCNK5 O95279 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra KCNK5 O95279 TSPAN33 Homo sapiens Q86UF1
Validated Y2H
32296183
Intra KCNK5 O95279 STRIT1 Homo sapiens P0DN84
Validated Y2H
32296183
Intra KCNK5 O95279 MAN2B2 Homo sapiens Q9Y2E5
Validated Y2H
32296183
Intra KCNK5 O95279 ATP5PF Homo sapiens P18859
Validated Y2H
32296183
Intra KCNK5 O95279 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra KCNK5 O95279 TMEM176A Homo sapiens Q96HP8
Validated Y2H
32296183
Intra KCNK5 O95279 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra KCNK5 O95279 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra KCNK5 O95279 COMT Homo sapiens P21964
Validated Y2H
32296183
Intra KCNK5 O95279 GJB2 Homo sapiens P29033
Validated Y2H
32296183
Intra KCNK5 O95279 SLC66A2 Homo sapiens Q8N2U9
Validated Y2H
32296183
Intra KCNK5 O95279 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra KCNK5 O95279 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra KCNK5 O95279 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra KCNK5 O95279 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra KCNK5 O95279 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra KCNK5 O95279 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra KCNK5 O95279 BNIP2 Homo sapiens Q12982
Validated Y2H
32296183
Intra KCNK5 O95279 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra KCNK5 O95279 TM4SF4 Homo sapiens P48230
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Migraine Without Aura

Common Migraine

Migraine With Or Without Aura, Susceptibility To

Migraine Without Aura, Susceptibility To

Acute Migraine Without Aura
Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome
Danubian Endemic Familial Nephropathy

Balkan Nephropathy

Balkan Endemic Nephropathy

Nephropathia Epidemica

Defn

Ben

Aristolochic Acid Nephropathy

Aan

Endemic Nephropathy Balkan

Balkan Nephritis
Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome
Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis

Marble Brain Disease

OPTB3

Guibaud-Vainsel Syndrome

Carbonic Anhydrase Ii Deficiency

Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis

Autosomal Recessive Osteopetrosis 3

Carbonic Anhydrase 2 Deficiency

Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis

Osteopetrosis Autosomal Recessive 3

Autosomal Recessive Osteopetrosis Type 3

Guibaud Vainsel Syndrome

Mixed Rta

Mixed Renal Tubular Acidosis

Renal Tubular Acidosis Type 3

Carbonic Anhydrase Ii Deficiency Syndrome

Carbonic Anhydrase Ii Variant

Osteopetrosis, Autosomal Recessive, Type 3

Carbonic Anhydrase 2
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07161 KCNK5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KCNK5 VGNC VGNC:42277
Mus musculus KCNK5 MGD MGI:1336175
Macaca mulatta KCNK5 VGNC VGNC:73995
Felis catus KCNK5 VGNC VGNC:67922
Rattus norvegicus KCNK5 RGD RGD:1564985
Bos taurus KCNK5 VGNC VGNC:30475
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