2. Gene
  3. ATP5PF - ATP synthase peripheral stalk subunit F6 Gene

ATP5PF - ATP synthase peripheral stalk subunit F6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATP 合酶外周茎亚基 F6

种属: Homo sapiens

同用名: F6; CF6; ATP5; ATPM; ATP5A; ATP5J

基因 ID: 522 | 基因类型: protein coding

关于 ATP5PF

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,724,500-25,735,653 (from NCBI)

This gene has 8 transcripts (splice variants) and 293 orthologues. Ubiquitous expression in heart (RPKM 71.0), kidney (RPKM 49.2) and 25 other tissues.

功能概要

线粒体 ATP 合酶催化 ATP 合成，利用氧化磷酸化过程中跨内膜的质子电化学梯度。它由两个连接的多亚基复合物组成：可溶性催化核心 F1 和跨膜成分 Fo，后者包含质子通道。 F1 复合体由 5 个不同的亚基 (alpha、beta、gamma、delta 和 epsilon) 组成，它们以 3 个 alpha、3 个 beta 和一个代表其他 3 个的比例组装。Fo 复合体有 9 个亚基 (a、b 、c、d、e、f、g、F6 和 8) 。该基因编码 Fo 复合体的 F6 亚基。 F1 和 Fo 相互作用需要 F6 亚基。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。该基因有 1 个或多个假基因。[RefSeq 提供，2016 年 2 月]

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]

ATP5PF 基因产物(7)

mRNA Protein Name
NM_001003696.2 NP_001003696.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001003697.2 NP_001003697.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001003701.2 NP_001003701.1 ATP synthase-coupling factor 6, mitochondrial isoform b precursor
NM_001003703.2 NP_001003703.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001320266.2 NP_001307195.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001320267.2 NP_001307196.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001685.5 NP_001676.2 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27499296 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: 通过直接分析推断
12110673 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: 通过直接分析推断
12110673 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of proton-transporting ATP synthase complex IDA
IDA: 通过直接分析推断
12110673 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATP5PF 蛋白结构

ATP-synt_F6

ATP-synt_F6: Mitochondrial ATP synthase coupling factor 6 (1 - 97)

  • 0
  • 100
  • 108 a.a.
蛋白主名 其他名称

ATP synthase-coupling factor 6, mitochondrial

ATP synthase subunit h

ATP5PF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ATP5PF P18859 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra ATP5PF P18859 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
Intra ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
Intra ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Validated Y2H
32296183
Intra ATP5PF P18859 PHOSPHO2 Homo sapiens Q8TCD6
Validated Y2H
32296183
Intra ATP5PF P18859 ATP5F1A Homo sapiens P25705
Crosslink
30021884
Intra ATP5PF P18859 ATP5F1A Homo sapiens P25705
Anti Tag CoIP
33961781
Intra ATP5PF P18859 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra ATP5PF P18859 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra ATP5PF P18859 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra ATP5PF P18859 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra ATP5PF P18859 ATP5PD Homo sapiens O75947
Anti Tag CoIP
33961781
Intra ATP5PF P18859 MIEF1 Homo sapiens Q9NQG6
Validated Y2H
32296183
Intra ATP5PF P18859 PTPN9 Homo sapiens P43378
Validated Y2H
32296183
Intra ATP5PF P18859 INPP5K Homo sapiens Q9BT40
Validated Y2H
32296183
Intra ATP5PF P18859 MALL Homo sapiens Q13021
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 21, Multiple Types

Cataract 21 Multiple Types

CTRCT21

Cca4

Cataract 21, Multiple Types, With Or Without Microcornea

Cataract, Pulverulent, Juvenile-Onset

Congenital Cataract Cerulean Type 4

Cataract, Congenital, Cerulean Type, 4

Cataract 21 Multiple Types With Or Without Microcornea

Cataract, Pulverulent Or Cerulean, With Or Without Microcornea

Cataract Pulverulent Juvenile-Onset

Congenital Cataract Blue Dot Type 4

Cataract, Type 21, Multiple Types
Oculoglandular Tularemia
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01212 ATP5PF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ATP5PF VGNC VGNC:26304
Rattus norvegicus ATP5PF RGD RGD:621376
Felis catus ATP5PF VGNC VGNC:68647
Mus musculus ATP5PF MGD MGI:107777
Canis familiaris ATP5PF VGNC VGNC:38265
Macaca mulatta ATP5PF VGNC VGNC:81288
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