INPP5K - inositol polyphosphate-5-phosphatase K Gene

中文名称：肌醇聚磷酸-5-磷酸酶 K

种属: Homo sapiens

同用名: PPS; SKIP; MDCCAID

基因 ID: 51763 | 基因类型: protein coding

关于 INPP5K

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,494,577-1,516,612 (from NCBI)

This gene has 20 transcripts (splice variants), 287 orthologues, 13 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 17.9), lung (RPKM 14.5) and 25 other tissues.

功能概要

该基因编码一种对多磷酸肌醇具有 5-磷酸酶活性的蛋白质。该蛋白质定位于缺乏肌动蛋白应力纤维区域的胞质溶胶。人们认为这种蛋白质可能负向调节肌动蛋白细胞骨架。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 10 月]

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin Cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

INPP5K 基因产物(3)

mRNA	Protein	Name
NM_001135642.2	NP_001129114.1	inositol polyphosphate 5-phosphatase K isoform 2
NM_016532.4	NP_057616.2	inositol polyphosphate 5-phosphatase K isoform 1
NM_130766.3	NP_570122.1	inositol polyphosphate 5-phosphatase K isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables inositol bisphosphate phosphatase activity	IDA IDA: 通过直接分析推断	10753883	GOA
enables inositol trisphosphate phosphatase activity	IDA IDA: 通过直接分析推断	10753883	GOA
enables phosphatidylinositol phosphate 5-phosphatase activity	IMP IMP: 通过突变表型推断	18774950	GOA
enables phosphatidylinositol trisphosphate phosphatase activity	IDA IDA: 通过直接分析推断	12556481	GOA
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IDA IDA: 通过直接分析推断	21712384	GOA
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IMP IMP: 通过突变表型推断	28190456	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16002321	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to epidermal growth factor stimulus	IDA IDA: 通过直接分析推断	21712384	GOA
involved in cellular response to insulin stimulus	IDA IDA: 通过直接分析推断	12556481	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	21712384	GOA
involved in dephosphorylation	IDA IDA: 通过直接分析推断	21712384	GOA
involved in dephosphorylation	IMP IMP: 通过突变表型推断	18774950	GOA
involved in negative regulation by host of viral transcription	IDA IDA: 通过直接分析推断	18774950	GOA
involved in negative regulation of D-glucose transmembrane transport	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of calcium ion transport	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of glycogen biosynthetic process	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of protein targeting to membrane	IDA IDA: 通过直接分析推断	12556481	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: 通过直接分析推断	18774950	GOA
involved in negative regulation of stress fiber assembly	IDA IDA: 通过直接分析推断	12556481	GOA
acts upstream of or within phosphatidylinositol dephosphorylation	IDA IDA: 通过直接分析推断	12536145	GOA
involved in phosphatidylinositol dephosphorylation	IDA IDA: 通过直接分析推断	12556481	GOA
involved in ruffle assembly	IDA IDA: 通过直接分析推断	12556481	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	10753883	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	12536145	GOA
located in membrane	IDA IDA: 通过直接分析推断	12536145	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	10753883	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18774950	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18774950	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12556481	GOA
located in ruffle	IDA IDA: 通过直接分析推断	12536145	GOA
located in ruffle membrane	IDA IDA: 通过直接分析推断	12556481	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	12556481	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INPP5K 蛋白结构

Exo_endo_phos

0
100
200
300
400
448 a.a.

蛋白主名

其他名称

inositol polyphosphate 5-phosphatase K

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

INPP5K 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
种属内	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
种属内	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
种属内	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
种属内	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
种属内	INPP5K	Q9BT40	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
种属内	INPP5K	Q9BT40	FADS6	Homo sapiens	Q8N9I5	Y2H Array	32296183
种属内	INPP5K	Q9BT40	FADS6	Homo sapiens	Q8N9I5	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	SFT2D2	Homo sapiens	O95562	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	SFT2D2	Homo sapiens	O95562	Y2H Array	32296183
种属内	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Y2H Array	32296183
种属内	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Validated Y2H	32296183
种属内	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Validated Y2H	25416956
种属内	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Y2H Array	32296183
种属内	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Anti Tag CoIP	33961781
种属内	INPP5K	Q9BT40	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
种属内	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	Y2H	16002321
种属内	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	Anti Tag CoIP	16002321
种属内	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	IF	16002321
种属内	INPP5K	Q9BT40	PBX3	Homo sapiens	Q96AL5	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	PBX3	Homo sapiens	Q96AL5	Y2H Array	32296183
种属内	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
种属内	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
种属内	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
种属内	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
种属内	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Muscular Dystrophy, Congenital, With Cataracts And Intellectual Disability

Congenital Muscular Dystrophy With Cataracts And Intellectual Disability

MDCCAID

Marinesco-Sjogren Syndrome

Marinesco-Sjögren Syndrome	MSS
Marinesco-Garland Syndrome	Garland-Moorhouse Syndrome
Hereditary Oligophrenic Cerebello-Lental Degeneration	Oligophrenic Cerebellolenticular Degeneration
Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism	Marinesco-Sjogren Syndrome-Myopathy
Marinesco-Sjogren-Garland Syndrome	Marinesco-Sjoegren Syndrome

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome	Macrocephaly-Intellectual Disability-Autism Syndrome
MCEPHAS

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy	Congenital Muscular Dystrophy Due To Lmna Mutation
MDCL	L-Cmd
Lmna-Related Congenital Muscular Dystrophy	Muscular Dystrophy, Congenital
Congenital Muscular Dystrophy Lmna-Related	Lmna-Related Cmd
Cmd	Mdc
Muscular Dystrophy Congenital Lmna-Related	Dystrophy, Muscular, Congenital, Lmna-Related
Dystrophy, Muscular, Congenital	Hereditary Muscular Dystrophy
Congenital Hereditary Muscular Dystrophy	Congenital Progressive Muscular Dystrophy
Hereditary Progressive Muscular Dystrophy

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06833	INPP5K Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	INPP5K	RGD	RGD:1359130
Bos taurus	INPP5K	VGNC	VGNC:30214
Mus musculus	INPP5K	MGD	MGI:1194899
Felis catus	INPP5K	VGNC	VGNC:62931
Canis familiaris	INPP5K	VGNC	VGNC:42036
Macaca mulatta	INPP5K	VGNC	VGNC:73695

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

INPP5K - inositol polyphosphate-5-phosphatase K Gene

关于 INPP5K

功能概要

INPP5K 基因产物(3)

INPP5K 蛋白结构

INPP5K 蛋白互作信息

关联疾病

直系同源

热门区域

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INPP5K - inositol polyphosphate-5-phosphatase K Gene

关于 INPP5K

功能概要

INPP5K 基因产物(3)

INPP5K 蛋白结构

INPP5K 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z