SIGLEC12 - sialic acid binding Ig like lectin 12 Gene

中文名称：唾液酸结合 Ig 样凝集素 12

种属: Homo sapiens

同用名: S2V; SLG; SIGLECL1; Siglec-XII

关于 SIGLEC12

功能概要

唾液酸结合免疫球蛋白样凝集素 (Siglec) 是属于免疫球蛋白超家族的细胞表面蛋白家族。它们通过选择性结合存在于糖脂和糖蛋白上的不同唾液酸部分来介导蛋白质-碳水化合物相互作用。该基因编码 Siglec 类 SIGLEC3 亚家族的成员。该亚家族成员的特征在于细胞外 V 组免疫球蛋白样结构域，后跟两个 C2 组免疫球蛋白样结构域，以及基于细胞质酪氨酸的基序 ITIM 和 SLAM 样。编码的蛋白质在酪氨酸磷酸化后已显示可募集含有 Src 同源 2 结构域的蛋白质酪氨酸磷酸酶 SHP1 和 SHP2。有人提出，该蛋白质通过作为抑制性受体发挥作用，参与巨噬细胞信号传导的负调节。该基因与 19q13.4 上的其他 SIGLEC3 样基因位于一个簇中。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with Other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]