MGST1 - microsomal glutathione S-transferase 1 Gene

中文名称：微粒体谷胱甘肽 S-转移酶 1

种属: Homo sapiens

同用名: MGST; PMAN; GST12; MGST-I

关于 MGST1

功能概要

MAPEG (类花生酸和谷胱甘肽代谢中的膜相关蛋白) 家族由六种人类蛋白质组成，其中两种与白三烯和前列腺素 E (炎症的重要介质) 的产生有关。其他家族成员表现出谷胱甘肽 S-转移酶和过氧化物酶活性，参与细胞防御有毒、致癌和具有药理学活性的亲电子化合物。该基因编码的蛋白质可催化谷胱甘肽与亲电子试剂的结合以及脂质氢过氧化物的还原。这种蛋白质定位于内质网和线粒体外膜，据认为可以保护这些膜免受氧化应激。已发现该基因的几种转录变体，一些非蛋白质编码和一些蛋白质编码。[RefSeq 提供，2012 年 5 月]

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating Glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]