1. Gene
  2. TMPRSS4 - transmembrane serine protease 4 Gene

TMPRSS4 - transmembrane serine protease 4 Gene

中文名称:跨膜丝氨酸蛋白酶 4

种属: Homo sapiens

同用名: CAP2; CAPH2; MT-SP2; TMPRSS3

基因 ID: 56649 | 基因类型: protein coding

关于 TMPRSS4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,077,078-118,125,505 (from NCBI)

This gene has 19 transcripts (splice variants), 148 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues.

功能概要

该基因编码丝氨酸蛋白酶家族的一个成员。已知丝氨酸蛋白酶参与多种生物过程,其功能失调通常会导致人类疾病和紊乱。该基因被鉴定为在胰腺癌中过表达的基因。编码的蛋白质与 N 末端锚定序列和包含丝氨酸蛋白酶结构域的糖基化细胞外区域结合。已发现该蛋白质可促进 SARS-CoV-2 进入宿主细胞。[RefSeq 提供,2021 年 8 月]

This gene encodes a member of the serine Protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine Protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]

TMPRSS4 基因产物(6)

mRNA Protein Name
NM_001083947.2 NP_001077416.2 transmembrane protease serine 4 isoform 3
NM_001173551.2 NP_001167022.2 transmembrane protease serine 4 isoform 4
NM_001173552.2 NP_001167023.2 transmembrane protease serine 4 isoform 5
NM_001290094.2 NP_001277023.2 transmembrane protease serine 4 isoform 6
NM_001290096.2 NP_001277025.2 transmembrane protease serine 4 isoform 7
NM_019894.4 NP_063947.2 transmembrane protease serine 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
24434139 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of growth rate IDA
IDA: 通过直接分析推断
29529050 GOA
involved in positive regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
32404436 GOA
involved in protein processing IDA
IDA: 通过直接分析推断
24434139 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
24434139 GOA
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
29529050 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
24434139 GOA
located in secretory granule IDA
IDA: 通过直接分析推断
29529050 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMPRSS4 蛋白结构

SRCR_2

SRCR_2: Scavenger receptor cysteine-rich domain (109 - 199)

Trypsin

Trypsin: Trypsin (206 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
蛋白主名 其他名称

transmembrane protease serine 4

channel-activating protease 2

TMPRSS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMPRSS4 Q9NRS4 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 RASGRP4 Homo sapiens Q8TDF6-2
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 RASGRP4 Homo sapiens Q8TDF6-2
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra TMPRSS4 Q9NRS4 BNIP3L Homo sapiens O60238
Y2H Array
32296183
Intra TMPRSS4 Q9NRS4 BNIP3L Homo sapiens O60238
Y2H Prey Pooling
32296183
Intra TMPRSS4 Q9NRS4 CSNK1D Homo sapiens P48730-2
Validated Y2H
32814053
Intra TMPRSS4 Q9NRS4 CSNK1D Homo sapiens P48730-2
Y2H Array
32814053
Intra TMPRSS4 Q9NRS4 CSNK1D Homo sapiens P48730-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Recessive Cerebral Atrophy
Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8

DFNB8

Dfnb10

Deafness, Autosomal Recessive 10

Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8

Nsrd8

Autosomal Recessive Nonsyndromic Deafness 8

Deafness, Autosomal Recessive 8/10

Autosomal Recessive Deafness 10

Autosomal Recessive Deafness 8

Childhood-Onset Neurosensory Autosomal Recessive Deafness 8

Nrsd8

Deafness, Autosomal Recessive, 8

Childhood-Onset Neurosensory Deafness Autosomal Recessive 8

Deafness Autosomal Recessive 10

Deafness Autosomal Recessive 8/10

Deafness Neurosensory Autosomal Recessive 8

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8

Deafness, Autosomal Recessive, Type 8/10

Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Colorectal Cancer, Hereditary Nonpolyposis, Type 8

HNPCC8

Hereditary Nonpolyposis Colorectal Cancer Type 8

Hereditary Non-Polyposis Colorectal Cancer 8

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8

Deafness, Autosomal Recessive 98

DFNB98

Autosomal Recessive Nonsyndromic Deafness 98

Autosomal Recessive Deafness 98

Deafness, Autosomal Recessive, 98

Deafness, Autosomal Recessive, Type 98

Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct

Enlarged Vestibular Aqueduct

DFNB4

Neurosensory Nonsyndromic Recessive Deafness 4

Enlarged Vestibular Aqueduct Syndrome

Nsrd4

Autosomal Recessive Nonsyndromic Deafness 4

Dilated Vestibular Aqueduct

Dva

Enlarged Vestibular Aqueduct, Digenic

Autosomal Recessive Deafness 4 With Enlarged Vestibular Aqueduct

Large Vestibular Aqueduct Syndrome

Deafness, Autosomal Recessive, 4

Deafness Neurosensory Autosomal Recessive 4

Eva

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 4

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 4

Deafness, Autosomal Recessive, Type 4 , With Enlarged Vestibular Aqueduct

Deafness, Autosomal Recessive 39

DFNB39

Autosomal Recessive Nonsyndromic Deafness 39

Autosomal Recessive Deafness 39

Deafness, Autosomal Recessive, 39

Congenital Neurosensory Deafness Autosomal Recessive 39

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39

Deafness, Autosomal Recessive, Type 39

Deafness, Autosomal Recessive 83

DFNB83

Autosomal Recessive Nonsyndromic Deafness 83

Autosomal Recessive Deafness 83

Deafness, Autosomal Recessive 77

DFNB77

Autosomal Recessive Nonsyndromic Deafness 77

Autosomal Recessive Deafness 77

Deafness, Autosomal Recessive, 77

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 77

Deafness, Autosomal Recessive, Type 77

Petroclival Meningioma
Deafness, Autosomal Recessive 61

DFNB61

Autosomal Recessive Nonsyndromic Deafness 61

Autosomal Recessive Deafness 61

Deafness, Autosomal Recessive, 61

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61

Deafness, Autosomal Recessive, Type 61

Deafness, Autosomal Recessive 42

DFNB42

Autosomal Recessive Nonsyndromic Deafness 42

Autosomal Recessive Deafness 42

Deafness, Autosomal Recessive, 42

Congenital Neurosensory Deafness Autosomal Recessive 42

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 42

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 42

Deafness, Autosomal Recessive, Type 42

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Deafness, Autosomal Recessive 12

DFNB12

Deafness, Autosomal Recessive 12, Modifier Of

Autosomal Recessive Nonsyndromic Deafness 12

Autosomal Recessive Deafness 12

Deafness, Autosomal Recessive, 12

Congenital Neurosensory Deafness Autosomal Recessive 12

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12

Deafness, Autosomal Recessive, Type 12

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome

Ush

Usher Syndromes

Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMPRSS4 VGNC VGNC:47634
Felis catus TMPRSS4 VGNC VGNC:66387
Bos taurus TMPRSS4 VGNC VGNC:36142
Macaca mulatta TMPRSS4 VGNC VGNC:78577
Rattus norvegicus TMPRSS4 RGD RGD:1305033
Mus musculus TMPRSS4 MGD MGI:2384877
Others TMPRSS4 NCBI