TSPAN33 - tetraspanin 33 Gene

中文名称：四跨膜蛋白 33

种属: Homo sapiens

同用名: PEN; PEN.; TSPAN-33

基因 ID: 340348 | 基因类型: protein coding

关于 TSPAN33

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:129,144,707-129,169,699 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 32 paralogues. Broad expression in kidney (RPKM 45.5), lymph node (RPKM 15.7) and 20 other tissues.

功能概要

启用酶结合活性。参与孔复合体组装；蛋白质定位于质膜；和蛋白质成熟。位于质膜。孔复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]

TSPAN33 基因产物(1)

mRNA	Protein	Name
NM_178562.5	NP_848657.1	tetraspanin-33

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	23091066	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23091066	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in pore complex assembly	IMP IMP: 通过突变表型推断	30463011	GOA
involved in protein localization to plasma membrane	IDA IDA: 通过直接分析推断	23091066	GOA
involved in protein maturation	IDA IDA: 通过直接分析推断	23091066	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	23091066	GOA
part of pore complex	IMP IMP: 通过突变表型推断	30463011	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSPAN33 蛋白结构

Tetraspannin

0
100
200
283 a.a.

蛋白主名

其他名称

tetraspanin-33

penumbra

TSPAN33 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	26686862
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Complementation	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GAD2	Homo sapiens	Q05329	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GAD2	Homo sapiens	Q05329	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15169	TSPAN33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TSPAN33	VGNC	VGNC:66633
Canis familiaris	TSPAN33	VGNC	VGNC:47922
Macaca mulatta	TSPAN33	VGNC	VGNC:79739
Bos taurus	TSPAN33	VGNC	VGNC:36438
Mus musculus	TSPAN33	MGD	MGI:1919012
Rattus norvegicus	TSPAN33	RGD	RGD:1560915

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