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  2. CISD2 - CDGSH iron sulfur domain 2 Gene

CISD2 - CDGSH iron sulfur domain 2 Gene

中文名称:CDGSH 铁硫结构域 2

种属: Homo sapiens

同用名: ERIS; WFS2; ZCD2; NAF-1; Miner1

基因 ID: 493856 | 基因类型: protein coding

关于 CISD2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,868,992-102,892,807 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.6), kidney (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种锌指蛋白,定位于内质网。编码的蛋白质结合铁/硫簇,可能参与钙稳态。该基因的缺陷是导致 Wolfram 综合征 2 的原因。[RefSeq 提供,2011 年 3 月]

The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]

CISD2 基因产物(1)

mRNA Protein Name
NM_001008388.5 NP_001008389.1 CDGSH iron-sulfur domain-containing protein 2

CISD2 蛋白结构

MitoNEET_N

MitoNEET_N: Iron-containing outer mitochondrial membrane protein N-terminus (1 - 66)

zf-CDGSH

zf-CDGSH: Iron-binding zinc finger CDGSH type (77 - 115)

  • 0
  • 100
  • 135 a.a.
蛋白主名 其他名称

CDGSH iron-sulfur domain-containing protein 2

endoplasmic reticulum intermembrane small protein

CISD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CISD2 Q8N5K1 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra CISD2 Q8N5K1 PNKP Homo sapiens Q96T60
Validated Y2H
32296183
Intra CISD2 Q8N5K1 CFHR5 Homo sapiens Q9BXR6
Validated Y2H
32296183
Intra CISD2 Q8N5K1 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra CISD2 Q8N5K1 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra CISD2 Q8N5K1 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra CISD2 Q8N5K1 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra CISD2 Q8N5K1 MAN2B2 Homo sapiens Q9Y2E5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 AQP10 Homo sapiens Q96PS8
Y2H Array
32296183
Intra CISD2 Q8N5K1 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra CISD2 Q8N5K1 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra CISD2 Q8N5K1 SLC13A3 Homo sapiens Q8WWT9
Validated Y2H
32296183
Intra CISD2 Q8N5K1 PLPPR2 Homo sapiens Q96GM1
Validated Y2H
32296183
Intra CISD2 Q8N5K1 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra CISD2 Q8N5K1 POMGNT1 Homo sapiens Q8WZA1
Validated Y2H
32296183
Intra CISD2 Q8N5K1 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra CISD2 Q8N5K1 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 HHATL Homo sapiens Q9HCP6
Validated Y2H
32296183
Intra CISD2 Q8N5K1 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra CISD2 Q8N5K1 TMEM43 Homo sapiens Q9BTV4
Validated Y2H
32296183
Intra CISD2 Q8N5K1 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra CISD2 Q8N5K1 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra CISD2 Q8N5K1 BCL2 Homo sapiens P10415
Anti Bait CoIP
20010695
Intra CISD2 Q8N5K1 BCL2 Homo sapiens P10415
Pull Down
20010695
Intra CISD2 Q8N5K1 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 NRG4 Homo sapiens Q8WWG1
Validated Y2H
32296183
Intra CISD2 Q8N5K1 BTN2A2 Homo sapiens Q8WVV5
Validated Y2H
32296183
Intra CISD2 Q8N5K1 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wolfram Syndrome 2

WFS2

Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome

Diabetes Insipidus
Noonan Syndrome 13

NS13

Primary Optic Atrophy
3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy

3-Methylglutaconic Aciduria Type 3

Costeff Syndrome

Mga3

Costeff Optic Atrophy Syndrome

Optic Atrophy Plus Syndrome

Infantile Optic Atrophy With Chorea And Spastic Paraplegia

3-Methylglutaconic Aciduria Type Iii

Autosomal Recessive Optic Atrophy Plus Syndrome

Autosomal Recessive Optic Atrophy Type 3

Opa3 Defect

MGCA3

Mga, Type Iii

Iraqi Jewish Optic Atrophy Plus

Mga Type Iii

Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

Iraqi-Jewish 'Optic Atrophy Plus'

Optic Atrophy 3, Autosomal Recessive

Opa3, Autosomal Recessive

Opa3-Related 3-Methylglutaconic Aciduria

Iraqi-Jewish Optic Atrophy Plus

Atrophy Of Optic Disc

3-Alpha Methylglutaconic Aciduria Type Iii

Optic Atrophy 3

Optic Atrophy Infantile With Chorea And Spastic Paraplegia

Autosomal Recessive Opa3

Autosomal Recessive Optic Atrophy 3

3-Methylglutaconic Aciduria 3

3-Alpha-Methylglutaconic Aciduria Type 3

Optic Atrophy 3 Autosomal Recessive

Atrophy, Optic

Atrophy, Optic, Plus Syndrome

Optic Nerve Atrophy

Primary Optic Atrophy

Oa - [Optic Atrophy]

Second Cranial Nerve Atrophy

Second Cranium Nerve Atrophy

Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1

WS1

Waardenburg Syndrome Type I

Waardenburg Syndrome With Dystopia Canthorum

Waardenburg'S Syndrome Type 1

Waardenburg Syndrome 1

Waardenburg Syndrome, Type I

Waardenburg Syndrome

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder

Waardenburg'S Syndrome

Waardenburg Syndrome

Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome

Van Der Hoeve Halbertsona Waardenburg Syndrome

Waardenburg Shah Syndrome

Waardenburg, Types I And/Or Ii

Mende Syndrome

Waardenburgs Syndrome

Waardenburg Syndrome, Type 4a

Optic Nerve Disease

Optic Neuropathy

Disorder Of The Second Nerve

Optic Nerve Disorder

Optic Nerve

Abnormality Of The Optic Nerve

Optic Nerve Disorders

Neuropathy, Optic

Disorder Of The Optic Nerve

Cranial Nerve Disease

Cranial Nerve Disorder

Disorder Of Cranial Nerve

Cranial Nerve Diseases

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CISD2 VGNC VGNC:27372
Felis catus CISD2 VGNC VGNC:78470
Macaca mulatta CISD2 VGNC VGNC:106563
Rattus norvegicus CISD2 RGD RGD:1566242
Mus musculus CISD2 MGD MGI:1914256
Canis familiaris CISD2 VGNC VGNC:39279