1. Gene
  2. TMEM97 - transmembrane protein 97 Gene

TMEM97 - transmembrane protein 97 Gene

中文名称:跨膜蛋白 97

种属: Homo sapiens

同用名: MAC30; sigma2R

基因 ID: 27346 | 基因类型: protein coding

关于 TMEM97

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,319,200-28,328,685 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Broad expression in testis (RPKM 51.1), liver (RPKM 43.9) and 23 other tissues.

功能概要

TMEM97 是一种保守的整合膜蛋白,在控制细胞胆固醇水平方面发挥作用 (Bartz 等人,2009 [PubMed 19583955]) 。[OMIM 提供,2009 年 8 月]

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular Cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM97 基因产物(1)

mRNA Protein Name
NM_014573.3 NP_055388.2 sigma intracellular receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19583955 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol homeostasis IDA
IDA: 通过直接分析推断
19583955 GOA
involved in positive regulation of lipoprotein transport IMP
IMP: 通过突变表型推断
30443021 GOA
involved in positive regulation of wound healing IMP
IMP: 通过突变表型推断
34233061 GOA
involved in regulation of intracellular cholesterol transport IMP
IMP: 通过突变表型推断
27378690 GOA
involved in regulation of intracellular lipid transport IMP
IMP: 通过突变表型推断
27378690 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum IDA
IDA: 通过直接分析推断
34233061 GOA
located in lysosome IDA
IDA: 通过直接分析推断
19583955 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
19583955 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19583955 GOA
located in rough endoplasmic reticulum IDA
IDA: 通过直接分析推断
19583955 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMEM97 蛋白结构

DUF2781

DUF2781: Protein of unknown function (DUF2781) (11 - 165)

  • 0
  • 100
  • 176 a.a.
蛋白主名 其他名称

sigma intracellular receptor 2

meningioma-associated protein 30

sigma-2 receptor

sigma2 receptor

TMEM97 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMEM97 Q5BJF2 SGPL1 Homo sapiens O95470 32296183
种属内
TMEM97 Q5BJF2 SGPL1 Homo sapiens O95470 32296183
种属内
TMEM97 Q5BJF2 NEMP1 Homo sapiens O14524-2 32296183
种属内
TMEM97 Q5BJF2 NEMP1 Homo sapiens O14524-2 32296183
种属内
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9 32296183
种属内
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9 32296183
种属内
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9 32296183
种属内
TMEM97 Q5BJF2 ARL13B Homo sapiens Q3SXY8 32296183
种属内
TMEM97 Q5BJF2 ARL13B Homo sapiens Q3SXY8 32296183
种属内
TMEM97 Q5BJF2 GPX8 Homo sapiens Q8TED1 32296183
种属内
TMEM97 Q5BJF2 GPX8 Homo sapiens Q8TED1 32296183
种属内
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5 32296183
种属内
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5 32296183
种属内
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5 32296183
种属内
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5 32296183
种属内
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5 32296183
种属内
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5 32296183
种属内
TMEM97 Q5BJF2 SPINT1 Homo sapiens O43278-2 32296183
种属内
TMEM97 Q5BJF2 SPINT1 Homo sapiens O43278-2 32296183
种属内
TMEM97 Q5BJF2 FXYD3 Homo sapiens Q14802-3 32296183
种属内
TMEM97 Q5BJF2 FXYD3 Homo sapiens Q14802-3 32296183
种属内
TMEM97 Q5BJF2 PLP1 Homo sapiens P60201-2 32296183
种属内
TMEM97 Q5BJF2 PLP1 Homo sapiens P60201-2 32296183
种属内
TMEM97 Q5BJF2 CD74 Homo sapiens P04233-2 32296183
种属内
TMEM97 Q5BJF2 CD74 Homo sapiens P04233-2 32296183
种属内
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4 32296183
种属内
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4 32296183
种属内
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4 32296183
种属内
TMEM97 Q5BJF2 AQP2 Homo sapiens P41181 32296183
种属内
TMEM97 Q5BJF2 AQP2 Homo sapiens P41181 32296183
种属内
TMEM97 Q5BJF2 AQP6 Homo sapiens Q13520 32296183
种属内
TMEM97 Q5BJF2 AQP6 Homo sapiens Q13520 32296183
种属内
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2 32296183
种属内
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2 32296183
种属内
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2 32296183
种属内
TMEM97 Q5BJF2 SLC14A2 Homo sapiens Q15849 32296183
种属内
TMEM97 Q5BJF2 SLC14A2 Homo sapiens Q15849 32296183
种属内
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6 32296183
种属内
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6 32296183
种属内
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6 32296183
种属内
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51 32296183
种属内
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51 32296183
种属内
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51 32296183
种属内
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902 32296183
种属内
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902 32296183
种属内
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902 32296183
种属内
TMEM97 Q5BJF2 MUC1 Homo sapiens P15941-11 32296183
种属内
TMEM97 Q5BJF2 MUC1 Homo sapiens P15941-11 32296183
种属内
TMEM97 Q5BJF2 AQP12B Homo sapiens A6NM10-2 32296183
种属内
TMEM97 Q5BJF2 AQP12B Homo sapiens A6NM10-2 32296183
种属内
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3 32296183
种属内
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3 32296183
种属内
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3 32296183
种属内
TMEM97 Q5BJF2 LEUTX Homo sapiens A8MZ59 32296183
种属内
TMEM97 Q5BJF2 LEUTX Homo sapiens A8MZ59 32296183
种属内
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
TMEM97 Q5BJF2 TMEM52B Homo sapiens Q4KMG9 32296183
种属内
TMEM97 Q5BJF2 TMEM52B Homo sapiens Q4KMG9 32296183
种属内
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71 32296183
种属内
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71 32296183
种属内
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71 32296183
种属内
TMEM97 Q5BJF2 SLC14A1 Homo sapiens Q13336-2 32296183
种属内
TMEM97 Q5BJF2 SLC14A1 Homo sapiens Q13336-2 32296183
种属内
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675 32296183
种属内
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675 32296183
种属内
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675 32296183
种属内
TMEM97 Q5BJF2 ATP6AP2 Homo sapiens O75787 32296183
种属内
TMEM97 Q5BJF2 ATP6AP2 Homo sapiens O75787 32296183
种属内
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183 32296183
种属内
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183 32296183
种属内
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183 32296183
种属内
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8 32296183
种属内
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8 32296183
种属内
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8 32296183
种属内
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2 32296183
种属内
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2 32296183
种属内
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2 32296183
种属内
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400 32296183
种属内
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400 32296183
种属内
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400 32296183
种属内
TMEM97 Q5BJF2 FFAR2 Homo sapiens O15552 32296183
种属内
TMEM97 Q5BJF2 FFAR2 Homo sapiens O15552 32296183
种属内
TMEM97 Q5BJF2 GPR37L1 Homo sapiens O60883 32296183
种属内
TMEM97 Q5BJF2 GPR37L1 Homo sapiens O60883 32296183
种属内
TMEM97 Q5BJF2 LRRC59 Homo sapiens Q96AG4 32296183
种属内
TMEM97 Q5BJF2 LRRC59 Homo sapiens Q96AG4 32296183
种属内
TMEM97 Q5BJF2 IFNGR2 Homo sapiens P38484 32296183
种属内
TMEM97 Q5BJF2 IFNGR2 Homo sapiens P38484 32296183
种属内
TMEM97 Q5BJF2 GJB3 Homo sapiens O75712 32296183
种属内
TMEM97 Q5BJF2 GJB3 Homo sapiens O75712 32296183
种属内
TMEM97 Q5BJF2 GJB5 Homo sapiens O95377 32296183
种属内
TMEM97 Q5BJF2 GJB5 Homo sapiens O95377 32296183
种属内
TMEM97 Q5BJF2 EBP Homo sapiens Q15125 32296183
种属内
TMEM97 Q5BJF2 EBP Homo sapiens Q15125 32296183
种属内
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680 32296183
种属内
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680 32296183
种属内
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680 32296183
种属内
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31 32296183
种属内
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31 32296183
种属内
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31 32296183
种属内
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21 32296183
种属内
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21 32296183
种属内
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21 32296183
种属内
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0 32296183
种属内
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0 32296183
种属内
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0 32296183
种属内
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84 32296183
种属内
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84 32296183
种属内
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84 32296183
种属内
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320 32296183
种属内
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320 32296183
种属内
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320 32296183
种属内
TMEM97 Q5BJF2 CD53 Homo sapiens P19397 32296183
种属内
TMEM97 Q5BJF2 CD53 Homo sapiens P19397 32296183
种属内
TMEM97 Q5BJF2 FRMD3 Homo sapiens A2A2Y4 32296183
种属内
TMEM97 Q5BJF2 FRMD3 Homo sapiens A2A2Y4 32296183
种属内
TMEM97 Q5BJF2 BIK Homo sapiens Q13323 32296183
种属内
TMEM97 Q5BJF2 BIK Homo sapiens Q13323 32296183
种属内
TMEM97 Q5BJF2 PDZK1IP1 Homo sapiens Q13113 32296183
种属内
TMEM97 Q5BJF2 PDZK1IP1 Homo sapiens Q13113 32296183
种属内
TMEM97 Q5BJF2 CLDN7 Homo sapiens O95471 32296183
种属内
TMEM97 Q5BJF2 CLDN7 Homo sapiens O95471 32296183
种属内
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375 32296183
种属内
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375 32296183
种属内
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375 32296183
种属内
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9 32296183
种属内
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9 32296183
种属内
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9 32296183
种属内
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
TMEM97 Q5BJF2 KIR2DL3 Homo sapiens P43628 32296183
种属内
TMEM97 Q5BJF2 KIR2DL3 Homo sapiens P43628 32296183
种属内
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2 32296183
种属内
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2 32296183
种属内
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C

NPC1

Niemann-Pick Disease, Type D

Niemann-Pick Disease Type C1

Niemann-Pick Disease With Cholesterol Esterification Block

Niemann-Pick Disease, Subacute Juvenile Form

Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

Npc

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease Without Sphingomyelinase Deficiency

Niemann-Pick Disease Type C

Niemann-Pick Disease Type D

Niemann-Pick C1 Disease

Niemann-Pick Disease C1

Niemann-Pick Disease Chronic Neuronopathic Form

Niemann-Pick Disease Nova Scotian Type

Niemann-Pick Disease Subacute Juvenile Form

Niemann-Pick Disease Type Ii

Niemann-Picks Disease Type C

Combined Oxidative Phosphorylation Deficiency 37

COXPD37

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMEM97 RGD RGD:1307423
Mus musculus TMEM97 MGD MGI:1916321
Macaca mulatta TMEM97 VGNC VGNC:79683
Bos taurus TMEM97 VGNC VGNC:36129
Canis familiaris TMEM97 VGNC VGNC:47617
Felis catus TMEM97 VGNC VGNC:97664
Others TMEM97 NCBI