2. Gene
  3. MRM1 - mitochondrial rRNA methyltransferase 1 Gene

MRM1 - mitochondrial rRNA methyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线粒体 rRNA 甲基转移酶 1

种属: Homo sapiens

基因 ID: 79922 | 基因类型: protein coding

关于 MRM1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,601,583-36,634,698 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 1.2), lymph node (RPKM 1.0) and 25 other tissues.

功能概要

启用 rRNA (鸟苷-2'-O-) -甲基转移酶活性。预计参与 rRNA 2'-O-甲基化。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MRM1 基因产物(1)

mRNA Protein Name
NM_024864.5 NP_079140.2 rRNA methyltransferase 1, mitochondrial precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables rRNA (guanosine-2'-O-)-methyltransferase activity EXP
EXP: 通过实验结果推断
25074936 GOA
enables rRNA (guanosine-2'-O-)-methyltransferase activity IMP
IMP: 通过突变表型推断
35177605 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
27184847 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRM1 蛋白结构

SpoU_sub_bind

SpoU_sub_bind: RNA 2'-O ribose methyltransferase substrate binding (51 - 128)

SpoU_methylase

SpoU_methylase: SpoU rRNA Methylase family (146 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

rRNA methyltransferase 1, mitochondrial

16S rRNA (guanosine(1145)-2'-O)-methyltransferase

MRM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MRM1 Q6IN84 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra MRM1 Q6IN84 CCL4L1 Homo sapiens Q8NHW4
Validated Y2H
32296183
Intra MRM1 Q6IN84 VKORC1L1 Homo sapiens Q8N0U8
Validated Y2H
32296183
Intra MRM1 Q6IN84 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra MRM1 Q6IN84 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra MRM1 Q6IN84 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra MRM1 Q6IN84 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra MRM1 Q6IN84 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra MRM1 Q6IN84 VSTM1 Homo sapiens Q6UX27-3
Validated Y2H
32296183
Intra MRM1 Q6IN84 BRICD5 Homo sapiens Q6PL45-2
Validated Y2H
32296183
Intra MRM1 Q6IN84 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra MRM1 Q6IN84 SYT3 Homo sapiens Q9BQG1
Validated Y2H
32296183
Intra MRM1 Q6IN84 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra MRM1 Q6IN84 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Intra MRM1 Q6IN84 NXPE3 Homo sapiens Q969Y0
Validated Y2H
32296183
Intra MRM1 Q6IN84 SPX Homo sapiens Q9BT56
Validated Y2H
32296183
Intra MRM1 Q6IN84 ITGAM Homo sapiens P11215
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra MRM1 Q6IN84 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra MRM1 Q6IN84 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra MRM1 Q6IN84 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra MRM1 Q6IN84 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra MRM1 Q6IN84 CGGBP1 Homo sapiens Q9UFW8
Anti Tag CoIP
28514442
Intra MRM1 Q6IN84 CGGBP1 Homo sapiens Q9UFW8
Anti Tag CoIP
33961781
Intra MRM1 Q6IN84 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
32296183
Intra MRM1 Q6IN84 CMTM3 Homo sapiens Q96MX0
Validated Y2H
32296183
Intra MRM1 Q6IN84 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra MRM1 Q6IN84 COQ8A Homo sapiens Q8NI60
Validated Y2H
32296183
Intra MRM1 Q6IN84 KLRG1 Homo sapiens Q96E93
Validated Y2H
32296183
Intra MRM1 Q6IN84 DNAJC30 Homo sapiens Q96LL9
Validated Y2H
32296183
Intra MRM1 Q6IN84 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 SYP Homo sapiens P08247
Y2H Array
32296183
Intra MRM1 Q6IN84 MAL2 Homo sapiens Q969L2
Y2H Prey Pooling
32296183
Intra MRM1 Q6IN84 MAL2 Homo sapiens Q969L2
Validated Y2H
32296183
Intra MRM1 Q6IN84 MAL2 Homo sapiens Q969L2
Y2H Array
32296183
Intra MRM1 Q6IN84 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 9

Mrx44

Mrx9

X-Linked Mental Retardation 44
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency

MCC1D

Mccd Type 1

Mcc1 Deficiency

Methylcrotonylglycinuria Type I

3-Methylcrotonylglycinuria I

3-Methylcrotonoyl-Coa Carboxylase 1 Deficiency

3-Methylcrotonylglycinuria Type I

Mcgi

3 Methylcrotonyl-Coa Carboxylase 1 Deficiency

3-Methylcrotonyl Coa Carboxylase 1 Deficiency
Raynaud-Claes Syndrome

Mrx49

MRXSRC

Mental Retardation, X-Linked 49

Mrx15

Clcn4-Related X-Linked Intellectual Disability Syndrome

Mental Retardation, X-Linked 15

X-Linked Mental Retardation 15

X-Linked Mental Retardation 49

Mental Retardation, X-Linked-49
Mitochondrial Dna Depletion Syndrome 4b

Mitochondrial Neurogastrointestinal Encephalopathy Syndrome

Mngie Syndrome

Thymidine Phosphorylase Deficiency

MTDPS4B

Mitochondrial Neurogastrointestinal Encephalopathy Disease

Mngie

Myoneurogastrointestinal Encephalopathy Syndrome

Ogimd

Oculogastrointestinal Muscular Dystrophy

Polip

Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction

Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related

Mngie, Polg-Related

Mepop

Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction

Mngie Disease

Mitochondrial Dna Depletion Syndrome 4b Mngie Type

Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related

Mngie Polg-Related

Mitochondrial Dna Depletion Syndrome, Type 4b

Visceral Myopathy Familial External Ophthalmoplegia
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2

PKD2

Polycystic Kidney Disease, Adult, Type Ii

Apkd2

Polycystic Kidney Disease, Type 2

Adpkd2

Adult Polycystic Kidney Disease Type 2

Autosomal Dominant Polycystic Kidney Disease 2

Pkd-2

Polycystic Kidney Disease Adult Type Ii

Polycystic Kidney Type 2 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 2
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08655 MRM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MRM1 VGNC VGNC:31605
Felis catus MRM1 VGNC VGNC:63582
Rattus norvegicus MRM1 RGD RGD:1566232
Mus musculus MRM1 MGD MGI:2443470
Macaca mulatta MRM1 VGNC VGNC:74833
Canis familiaris MRM1 VGNC VGNC:43366
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