VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

中文名称：维生素 K 环氧还原酶复合物亚基 1 样 1

种属: Homo sapiens

基因 ID: 154807 | 基因类型: protein coding

关于 VKORC1L1

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:65,865,772-65,959,558 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 25.2), lung (RPKM 7.7) and 23 other tissues.

功能概要

该基因编码一种在维生素 K 循环中很重要的酶，该酶参与维生素 K 依赖性蛋白质中存在的谷氨酸残基的羧化。编码的酶催化维生素 K 2,3-环氧化物的脱环氧化作用。氧化应激可能会上调该基因的表达，编码的蛋白质可能会保护细胞和膜蛋白免受氧化损伤。该基因和相关基因 (基因 ID：79001) 可能是由祖先基因的基因复制产生的。[RefSeq 提供，2016 年 10 月]

This gene encodes an Enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded Enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

VKORC1L1 基因产物(2)

mRNA	Protein	Name
NM_001284342.3	NP_001271271.1	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2
NM_173517.6	NP_775788.2	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	EXP EXP: 通过实验结果推断	21367861	GOA
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA IDA: 通过直接分析推断	21367861	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to oxidative stress	IMP IMP: 通过突变表型推断	21367861	GOA
involved in peptidyl-glutamic acid carboxylation	IMP IMP: 通过突变表型推断	24532791	GOA
involved in vitamin K metabolic process	IDA IDA: 通过直接分析推断	21367861	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	21367861	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VKORC1L1 蛋白结构

VKOR

0
100
176 a.a.

蛋白主名

其他名称

vitamin K epoxide reductase complex subunit 1-like protein 1

VKORC1-like protein 1

VKORC1L1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Anti Tag CoIP	33961781
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors

Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X

Vkcfd

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2

VKCFD2	Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15660	VKORC1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	VKORC1L1	MGD	MGI:1916818
Canis familiaris	VKORC1L1	VGNC	VGNC:82304
Rattus norvegicus	VKORC1L1	RGD	RGD:1303249
Bos taurus	VKORC1L1	VGNC	VGNC:58426
Macaca mulatta	VKORC1L1	VGNC	VGNC:79322

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

关于 VKORC1L1

功能概要

VKORC1L1 基因产物(2)

VKORC1L1 蛋白结构

VKORC1L1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

关于 VKORC1L1

功能概要

VKORC1L1 基因产物(2)

VKORC1L1 蛋白结构

VKORC1L1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z