1. Gene
  2. AGTRAP - angiotensin II receptor associated protein Gene

AGTRAP - angiotensin II receptor associated protein Gene

中文名称:血管紧张素 II 受体相关蛋白

种属: Homo sapiens

同用名: ATRAP

基因 ID: 57085 | 基因类型: protein coding

关于 AGTRAP

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,736,136-11,750,769 (from NCBI)

This gene has 14 transcripts (splice variants) and 177 orthologues. Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues.

功能概要

该基因编码定位于质膜和核周囊泡结构的跨膜蛋白。该基因产物与血管紧张素 II I 型受体相互作用并负向调节血管紧张素 II 信号传导。该基因的选择性剪接会产生编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AGTRAP 基因产物(5)

mRNA Protein Name
NM_001040194.2 NP_001035284.1 type-1 angiotensin II receptor-associated protein isoform b
NM_001040195.2 NP_001035285.1 type-1 angiotensin II receptor-associated protein isoform c
NM_001040196.2 NP_001035286.1 type-1 angiotensin II receptor-associated protein isoform d
NM_001040197.2 NP_001035287.1 type-1 angiotensin II receptor-associated protein isoform e
NM_020350.5 NP_065083.3 type-1 angiotensin II receptor-associated protein isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AGTRAP 蛋白结构

AGTRAP

AGTRAP: Angiotensin II, type I receptor-associated protein (AGTRAP) (1 - 159)

  • 0
  • 100
  • 159 a.a.
蛋白主名 其他名称

type-1 angiotensin II receptor-associated protein

AT1 receptor-associated protein

AGTRAP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AGTRAP Q6RW13 SUCLA2 Homo sapiens E5KS60
Y2H Array
25416956
Intra AGTRAP Q6RW13 SSX5 Homo sapiens O60225
Validated Y2H
25416956
Intra AGTRAP Q6RW13 SSX5 Homo sapiens O60225
Y2H Array
25416956
Intra AGTRAP Q6RW13 SSX5 Homo sapiens O60225
Y2H Array
29892012
Intra AGTRAP Q6RW13 SSX5 Homo sapiens O60225
Y2H Array
31515488
Intra AGTRAP Q6RW13 GDNF Homo sapiens P39905
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 GDNF Homo sapiens P39905
Validated Y2H
25416956
Intra AGTRAP Q6RW13 GAD1 Homo sapiens Q8IVA8
Validated Y2H
25416956
Intra AGTRAP Q6RW13 FASTKD3 Homo sapiens Q14CZ7
Y2H Array
25416956
Intra AGTRAP Q6RW13 FASTKD3 Homo sapiens Q14CZ7
Validated Y2H
25416956
Intra AGTRAP Q6RW13 SYT16 Homo sapiens Q17RD7
Y2H Array
31515488
Intra AGTRAP Q6RW13 SYT16 Homo sapiens Q17RD7
Validated Y2H
25416956
Intra AGTRAP Q6RW13 SYT16 Homo sapiens Q17RD7
Y2H Array
29892012
Intra AGTRAP Q6RW13 PBX3 Homo sapiens Q5JS98
Y2H Array
25416956
Intra AGTRAP Q6RW13 PBX3 Homo sapiens Q5JS98
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 PTPN9 Homo sapiens Q6IQ43
Y2H Array
25416956
Intra AGTRAP Q6RW13 STAG3L1 Homo sapiens Q7L1H2
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 STAG3L1 Homo sapiens Q7L1H2
Validated Y2H
25416956
Intra AGTRAP Q6RW13 STAG3L1 Homo sapiens Q7L1H2
Y2H Array
25416956
Intra AGTRAP Q6RW13 BPIFA2 Homo sapiens Q96DR5
Y2H Array
25416956
Intra AGTRAP Q6RW13 BPIFA2 Homo sapiens Q96DR5
Validated Y2H
25416956
Intra AGTRAP Q6RW13 MCEE Homo sapiens Q96PE7
Validated Y2H
25416956
Intra AGTRAP Q6RW13 MCEE Homo sapiens Q96PE7
Y2H Array
25416956
Intra AGTRAP Q6RW13 MCEE Homo sapiens Q96PE7
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 MCEE Homo sapiens Q96PE7
Y2H Array
31515488
Intra AGTRAP Q6RW13 H4C7 Homo sapiens Q99525
Y2H Array
25416956
Intra AGTRAP Q6RW13 H4C7 Homo sapiens Q99525
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 SSX3 Homo sapiens Q99909
Validated Y2H
25416956
Intra AGTRAP Q6RW13 SSX3 Homo sapiens Q99909
Y2H Array
25416956
Intra AGTRAP Q6RW13 MUTYH Homo sapiens Q9UIF7-3
Validated Y2H
25416956
Intra AGTRAP Q6RW13 MUTYH Homo sapiens Q9UIF7-3
Y2H Array
25416956
Intra AGTRAP Q6RW13 NDRG4 Homo sapiens Q9ULP0
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 NDRG4 Homo sapiens Q9ULP0
Y2H Array
25416956
Intra AGTRAP Q6RW13 ISCU Homo sapiens Q9H1K1
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 TFAM Homo sapiens Q00059
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 TFAM Homo sapiens Q00059
Validated Y2H
25416956
Intra AGTRAP Q6RW13 ALDH18A1 Homo sapiens P54886
Validated Y2H
25416956
Intra AGTRAP Q6RW13 HSCB Homo sapiens Q8IWL3
Y2H Array
31515488
Intra AGTRAP Q6RW13 HSCB Homo sapiens Q8IWL3
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 HSCB Homo sapiens Q8IWL3
Y2H Array
25416956
Intra AGTRAP Q6RW13 AP3M1 Homo sapiens Q9Y2T2
Validated Y2H
25416956
Intra AGTRAP Q6RW13 AP3M1 Homo sapiens Q9Y2T2
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 FARS2 Homo sapiens O95363
Y2H Array
25416956
Intra AGTRAP Q6RW13 PIMREG Homo sapiens Q9BSJ6
Y2H Array
25416956
Intra AGTRAP Q6RW13 PIMREG Homo sapiens Q9BSJ6
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 FAM114A1 Homo sapiens Q8IWE2
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 RMDN2 Homo sapiens Q96LZ7
Y2H Array
25416956
Intra AGTRAP Q6RW13 RMDN2 Homo sapiens Q96LZ7
Validated Y2H
25416956
Intra AGTRAP Q6RW13 SNX1 Homo sapiens Q13596
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 SNX1 Homo sapiens Q13596
Y2H Array
25416956
Intra AGTRAP Q6RW13 ACSF2 Homo sapiens Q96CM8
Y2H Array
31515488
Intra AGTRAP Q6RW13 TXN2 Homo sapiens Q99757
Y2H Array
25416956
Intra AGTRAP Q6RW13 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
Intra AGTRAP Q6RW13 GTF3C1 Homo sapiens Q12789
Validated Y2H
25416956
Intra AGTRAP Q6RW13 HMGB1 Homo sapiens P09429
Validated Y2H
25416956
Intra AGTRAP Q6RW13 HMGB1 Homo sapiens P09429
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 HMGB1 Homo sapiens P09429
Y2H Array
25416956
Intra AGTRAP Q6RW13 NFYB Homo sapiens P25208
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 HARS2 Homo sapiens P49590
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 HARS2 Homo sapiens P49590
Y2H Array
25416956
Intra AGTRAP Q6RW13 NKG7 Homo sapiens Q16617
Y2H Array
25416956
Intra AGTRAP Q6RW13 CD160 Homo sapiens O95971
Validated Y2H
25416956
Intra AGTRAP Q6RW13 CD160 Homo sapiens O95971
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 PCTP Homo sapiens Q9UKL6
Y2H Array
25416956
Intra AGTRAP Q6RW13 TUBA1B Homo sapiens P68363
Y2H Array
25416956
Intra AGTRAP Q6RW13 ECPAS Homo sapiens Q5VYK3
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 ECPAS Homo sapiens Q5VYK3
Validated Y2H
25416956
Intra AGTRAP Q6RW13 ECPAS Homo sapiens Q5VYK3
Y2H Array
25416956
Intra AGTRAP Q6RW13 MRM1 Homo sapiens Q6IN84
Validated Y2H
25416956
Intra AGTRAP Q6RW13 MRM1 Homo sapiens Q6IN84
Y2H Array
25416956
Intra AGTRAP Q6RW13 TCEANC2 Homo sapiens Q96MN5
Validated Y2H
25416956
Intra AGTRAP Q6RW13 TCEANC2 Homo sapiens Q96MN5
Y2H Array
25416956
Intra AGTRAP Q6RW13 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 ARFIP2 Homo sapiens P53365
Validated Y2H
25416956
Intra AGTRAP Q6RW13 TBRG4 Homo sapiens Q969Z0
Y2H Array
25416956
Intra AGTRAP Q6RW13 MYG1 Homo sapiens Q9HB07
Y2H Array
31515488
Intra AGTRAP Q6RW13 CAPNS1 Homo sapiens P04632
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 CAPNS1 Homo sapiens P04632
Y2H Array
25416956
Intra AGTRAP Q6RW13 GABARAPL2 Homo sapiens P60520
Validated Y2H
25416956
Intra AGTRAP Q6RW13 GABARAPL2 Homo sapiens P60520
Y2H Array
25416956
Intra AGTRAP Q6RW13 GABARAPL2 Homo sapiens P60520
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 NFU1 Homo sapiens Q9UMS0
Validated Y2H
25416956
Intra AGTRAP Q6RW13 NFU1 Homo sapiens Q9UMS0
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra AGTRAP Q6RW13 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 MIEF1 Homo sapiens Q9NQG6
Y2H Array
25416956
Intra AGTRAP Q6RW13 MIEF1 Homo sapiens Q9NQG6
Validated Y2H
25416956
Intra AGTRAP Q6RW13 FHIP1B Homo sapiens Q8N612
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 FHIP1B Homo sapiens Q8N612
Validated Y2H
25416956
Intra AGTRAP Q6RW13 FHIP1B Homo sapiens Q8N612
Y2H Array
25416956
Intra AGTRAP Q6RW13 SPG21 Homo sapiens Q9NZD8
Y2H Array
31515488
Intra AGTRAP Q6RW13 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 PTPN9 Homo sapiens P43378
Y2H
21516116
Intra AGTRAP Q6RW13 PTPN9 Homo sapiens P43378
Y2H Array
31515488
Intra AGTRAP Q6RW13 PTPN9 Homo sapiens P43378
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 PTPN9 Homo sapiens P43378
Y2H Array
25416956
Intra AGTRAP Q6RW13 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra AGTRAP Q6RW13 COQ8A Homo sapiens Q8NI60
Y2H Array
31515488
Intra AGTRAP Q6RW13 COQ8A Homo sapiens Q8NI60
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 COQ8A Homo sapiens Q8NI60
Validated Y2H
25416956
Intra AGTRAP Q6RW13 COQ8A Homo sapiens Q8NI60
Y2H Array
25416956
Intra AGTRAP Q6RW13 PITPNC1 Homo sapiens Q9UKF7
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 MIEF2 Homo sapiens Q96C03
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 MIEF2 Homo sapiens Q96C03
Validated Y2H
25416956
Intra AGTRAP Q6RW13 PDHX Homo sapiens O00330
Y2H Array
31515488
Intra AGTRAP Q6RW13 PDHX Homo sapiens O00330
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 PDHX Homo sapiens O00330
Y2H
21516116
Intra AGTRAP Q6RW13 MTERF3 Homo sapiens Q96E29
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 GAD2 Homo sapiens Q05329
Validated Y2H
25416956
Intra AGTRAP Q6RW13 GAD2 Homo sapiens Q05329
Y2H Array
25416956
Intra AGTRAP Q6RW13 GAD2 Homo sapiens Q05329
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 TPD52L3 Homo sapiens Q96J77
Y2H Prey Pooling
25416956
Intra AGTRAP Q6RW13 TPD52L3 Homo sapiens Q96J77
Validated Y2H
25416956
Intra AGTRAP Q6RW13 ARAF Homo sapiens Q96II5
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypertensive Retinopathy
Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AGTRAP VGNC VGNC:69604
Rattus norvegicus AGTRAP RGD RGD:1359346
Bos taurus AGTRAP VGNC VGNC:25747
Mus musculus AGTRAP MGD MGI:1339977
Canis familiaris AGTRAP VGNC VGNC:37722