SSX5 - SSX family member 5 Gene

中文名称：SSX 家族成员 5

种属: Homo sapiens

关于 SSX5

功能概要

该基因的产物属于高度同源的滑膜肉瘤 X (SSX) 断点蛋白家族。这些蛋白质可能起到转录抑制因子的作用。它们还能够在癌症患者中引发自发的体液和细胞免疫反应，并且是基于癌症疫苗的免疫疗法的潜在有用靶点。虽然一些相关的 SSX 基因参与了 t (X;18) (p11.2;q11.2) 易位，这种易位在所有滑膜肉瘤中都有发现，但该基因似乎并未参与此类易位。已经为该基因鉴定了编码不同亚型的两个转录物变体。[RefSeq 提供，2013 年 7 月]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]