2. Gene
  3. NFYB - nuclear transcription factor Y subunit beta Gene

NFYB - nuclear transcription factor Y subunit beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核转录因子 Y 亚基β

种属: Homo sapiens

同用名: HAP3; CBF-A; CBF-B; NF-YB

基因 ID: 4801 | 基因类型: protein coding

关于 NFYB

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,117,086-104,138,210 (from NCBI)

This gene has 5 transcripts (splice variants), 244 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是三聚体复合物的一个亚基，形成高度保守的转录因子，可与多种基因启动子区域的 CCAAT 基序高度特异性结合。该基因产物 B 亚基与 C 亚基形成紧密的二聚体，这是 A 亚基结合的先决条件。由此产生的三聚体以高特异性和亲和力与 DNA 结合。亚基 B 和 C 每个都包含一个组蛋白样基序。两种类型的证据支持对这些亚基组蛋白性质的观察；蛋白质序列比对和突变体实验。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

NFYB 基因产物(16)

mRNA Protein Name
NM_001414518.1 NP_001401447.1 nuclear transcription factor Y subunit beta isoform a
NM_001414519.1 NP_001401448.1 nuclear transcription factor Y subunit beta isoform a
NM_001414520.1 NP_001401449.1 nuclear transcription factor Y subunit beta isoform b
NM_001414521.1 NP_001401450.1 nuclear transcription factor Y subunit beta isoform b
NM_001414522.1 NP_001401451.1 nuclear transcription factor Y subunit beta isoform c
NM_001414523.1 NP_001401452.1 nuclear transcription factor Y subunit beta isoform d
NM_001414524.1 NP_001401453.1 nuclear transcription factor Y subunit beta isoform d
NM_001414525.1 NP_001401454.1 nuclear transcription factor Y subunit beta isoform d
NM_001414526.1 NP_001401455.1 nuclear transcription factor Y subunit beta isoform d
NM_001414527.1 NP_001401456.1 nuclear transcription factor Y subunit beta isoform e
NM_001414528.1 NP_001401457.1 nuclear transcription factor Y subunit beta isoform f
NM_001414529.1 NP_001401458.1 nuclear transcription factor Y subunit beta isoform f
NM_001414530.1 NP_001401459.1 nuclear transcription factor Y subunit beta isoform g
NM_001414531.1 NP_001401460.1 nuclear transcription factor Y subunit beta isoform h
NM_001414532.1 NP_001401461.1 nuclear transcription factor Y subunit beta isoform h
NM_006166.4 NP_006157.1 nuclear transcription factor Y subunit beta isoform b

NFYB 蛋白结构

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (58 - 122)

  • 0
  • 100
  • 207 a.a.
蛋白主名 其他名称

nuclear transcription factor Y subunit beta

CAAT box DNA-binding protein subunit B

NFYB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NFYB P25208 NFYA Homo sapiens P23511-2
Y2H Array
32296183
Intra NFYB P25208 NFYA Homo sapiens P23511-2
Anti Tag CoIP
26496610
Intra NFYB P25208 NFYA Homo sapiens P23511-2
Y2H Prey Pooling
32296183
Intra NFYB P25208 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra NFYB P25208 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra NFYB P25208 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra NFYB P25208 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra NFYB P25208 TP53 Homo sapiens P04637
Anti Bait CoIP
23734815
Intra NFYB P25208 TP53 Homo sapiens P04637
Anti Bait CoIP
16959611
Intra NFYB P25208 NFYA Homo sapiens P23511
Y2H Array
25416956
Intra NFYB P25208 NFYA Homo sapiens P23511
Anti Bait CoIP
16959611
Intra NFYB P25208 NFYC Homo sapiens Q13952
Anti Tag CoIP
26496610
Intra NFYB P25208 NFYC Homo sapiens Q13952
X-Ray Diffraction
12401788
Intra NFYB P25208 NFYC Homo sapiens Q13952
Y2H
21988832
Intra NFYB P25208 DRAP1 Homo sapiens Q14919
Y2H Pooling
16189514
Intra NFYB P25208 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra NFYB P25208 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Intra NFYB P25208 POLE4 Homo sapiens Q9NR33
Validated Y2H
25416956
Intra NFYB P25208 POLE4 Homo sapiens Q9NR33
Validated Y2H
32296183
Intra NFYB P25208 POLE4 Homo sapiens Q9NR33
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cyclosporiasis

Cyclosporosis

Cyclospora Infection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103001 HMN-154 97.21% 否
HY-RS09272 NFYB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NFYB MGD MGI:97317
Macaca mulatta NFYB VGNC VGNC:97795
Felis catus NFYB VGNC VGNC:97525
Rattus norvegicus NFYB RGD RGD:3172
Bos taurus NFYB VGNC VGNC:32056
Canis familiaris NFYB VGNC VGNC:43791
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