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  4. HMN-154

HMN-154是一种新型的苯磺酰胺类抗癌化合物。HMN-154与NF-YB相互作用，从而中断NF-Y异源三聚体与DNA的结合。

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HMN-154 Chemical Structure

HMN-154 Chemical Structure

CAS No. : 173528-92-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2338
In-stock
1 mg ￥1160
In-stock
5 mg ￥2900
In-stock
10 mg ￥4400
In-stock
25 mg 现货 询价
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

HMN-154 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

IC50 & Target

IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)[1]
体外研究
(In Vitro)

HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HMN-154 相关抗体:
分子量

366.43

Formula

C20H18N2O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 15 mg/mL (40.94 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7290 mL 13.6452 mL 27.2903 mL
5 mM 0.5458 mL 2.7290 mL 5.4581 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

Cells are seeded into a 96-well microplate at a cell density of 10000/well. Drug is added on the next day, and the plate then is incubated for 72 h at 37°C. The growth inhibitory concentration is measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

HMN-154 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7290 mL 13.6452 mL 27.2903 mL 68.2259 mL
5 mM 0.5458 mL 2.7290 mL 5.4581 mL 13.6452 mL
10 mM 0.2729 mL 1.3645 mL 2.7290 mL 6.8226 mL
15 mM 0.1819 mL 0.9097 mL 1.8194 mL 4.5484 mL
20 mM 0.1365 mL 0.6823 mL 1.3645 mL 3.4113 mL
25 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7290 mL
30 mM 0.0910 mL 0.4548 mL 0.9097 mL 2.2742 mL
40 mM 0.0682 mL 0.3411 mL 0.6823 mL 1.7056 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HMN-154173528-92-2HMN154HMN 154OthersInhibitorinhibitorinhibit

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产品名称：
HMN-154
目录号：
HY-103001
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