2. Gene
  3. NFYC - nuclear transcription factor Y subunit gamma Gene

NFYC - nuclear transcription factor Y subunit gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核转录因子 Y 亚基γ

种属: Homo sapiens

同用名: HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A

基因 ID: 4802 | 基因类型: protein coding

关于 NFYC

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,691,704-40,771,603 (from NCBI)

This gene has 24 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues.

功能概要

该基因编码三聚体复合物的一个亚基，形成高度保守的转录因子，以高特异性结合多种基因启动子中的 CCAAT 基序。编码的蛋白质 C 亚基与 B 亚基形成紧密二聚体，这是 A 亚基结合的先决条件。由此产生的三聚体以高特异性和亲和力与 DNA 结合。亚基 B 和 C 每个都包含一个组蛋白样基序。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

NFYC 基因产物(7)

mRNA Protein Name
NM_001142587.2 NP_001136059.1 nuclear transcription factor Y subunit gamma isoform 3
NM_001142588.2 NP_001136060.1 nuclear transcription factor Y subunit gamma isoform 1
NM_001142589.2 NP_001136061.1 nuclear transcription factor Y subunit gamma isoform 4
NM_001142590.2 NP_001136062.1 nuclear transcription factor Y subunit gamma isoform 5
NM_001308114.1 NP_001295043.1 nuclear transcription factor Y subunit gamma isoform 6
NM_001308115.2 NP_001295044.1 nuclear transcription factor Y subunit gamma isoform 7
NM_014223.5 NP_055038.2 nuclear transcription factor Y subunit gamma isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15243141 GOA
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11256944 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12401788 GOA
contributes to transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
11256944 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23332751 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15243141 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CCAAT-binding factor complex IDA
IDA: 通过直接分析推断
15243141 GOA
part of CCAAT-binding factor complex IPI
IPI: 通过物理相互作用推断
23332751 GOA
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
11256944 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15243141 GOA
part of protein-DNA complex IDA
IDA: 通过直接分析推断
11256944 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFYC 蛋白结构

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (42 - 105)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

nuclear transcription factor Y subunit gamma

CAAT box DNA-binding protein subunit C

NFYC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NFYC Q13952 NFYB Homo sapiens P25208
Affinity Chrom
35140242
Intra NFYC Q13952 NFYB Homo sapiens P25208
BioID
35140242
Intra NFYC Q13952 NFYB Homo sapiens P25208
Y2H Pooling
20936779
Intra NFYC Q13952 NFYB Homo sapiens P25208
Anti Tag CoIP
33961781
Intra NFYC Q13952 NFYA Homo sapiens P23511
Anti Tag CoIP
33961781
Intra NFYC Q13952 NFYA Homo sapiens P23511
Affinity Chrom
35140242
Intra NFYC Q13952 NFYA Homo sapiens P23511
BioID
35140242
Intra NFYC Q13952 NFYA Homo sapiens P23511
Y2H Pooling
20936779
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Choroid Plexus Cancer

Choroid Plexus Carcinoma

Choroid Plexus Neoplasms

Choroid Plexus Neoplasm

Tumor Of Choroid Plexus

Tumor Of The Choroid Plexus

Choroid Plexus Tumor

Choroid Plexus Tumors

Anaplastic Choroid Plexus Papilloma

Choroid Plexus Papilloma Nos

Papilloma Of Choroid Plexus

Plexus Choroideus Papilloma

Choroid Plexus Papilloma In Fourth Ventricle

Plexus Choroideus Papilloma In Fourth Ventricle
Neonatal Candidiasis

Neonatal Candida Infection

Neonatal Monilia Infection

Neonatal Moniliasis
Adult Acute Monocytic Leukemia

Adult Acute Monoblastic And Acute Monocytic Leukemia
Cyclosporiasis

Cyclosporosis

Cyclospora Infection
Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09273 NFYC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NFYC VGNC VGNC:106416
Felis catus NFYC VGNC VGNC:68492
Canis familiaris NFYC VGNC VGNC:43792
Bos taurus NFYC VGNC VGNC:32057
Mus musculus NFYC MGD MGI:107901
Rattus norvegicus NFYC RGD RGD:3173
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