NFYA - nuclear transcription factor Y subunit alpha Gene

中文名称：核转录因子 Y 亚基 α

种属: Homo sapiens

同用名: HAP2; CBF-A; CBF-B; NF-YA

关于 NFYA

功能概要

该基因编码的蛋白质是三聚体复合物的一个亚基，形成高度保守的转录因子，可与多种基因启动子区域的 CCAAT 基序结合。亚基 A 与由 B 和 C 亚基组成的紧密二聚体结合，产生以高特异性和亲和力结合 DNA 的三聚体。复合物的序列特异性相互作用是由 A 亚基产生的，表明其作为调节亚基的作用。此外，有证据表明该基因产物存在转录后调控，无论是通过蛋白质降解还是通过翻译控制。进一步的调控表现为富含谷氨酰胺的激活结构域中的选择性剪接，这两种亚型具有明显的组织特异性偏好。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]