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  3. GTF3C1 - general transcription factor IIIC subunit 1 Gene

GTF3C1 - general transcription factor IIIC subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：一般转录因子 IIIC 亚基 1

种属: Homo sapiens

同用名: TFIIIC; TFIIIC220; TFIIICalpha

基因 ID: 2975 | 基因类型: protein coding

关于 GTF3C1

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,460,613-27,549,913 (from NCBI)

This gene has 13 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues.

功能概要

预测有助于 DNA 结合活性。预计参与 RNA 聚合酶 III 的 5S 类 rRNA 转录和 RNA 聚合酶 III 启动子的转录起始。位于核仁和核质中。转录因子 TFIIIC 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF3C1 基因产物(2)

mRNA Protein Name
NM_001286242.2 NP_001273171.1 general transcription factor 3C polypeptide 1 isoform 2
NM_001520.4 NP_001511.2 general transcription factor 3C polypeptide 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: 通过直接分析推断
17409385 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17409385 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription factor TFIIIC complex IDA
IDA: 通过直接分析推断
17409385 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GTF3C1 蛋白结构

B-block_TFIIIC

B-block_TFIIIC: B-block binding subunit of TFIIIC (175 - 249)

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  • 2109 a.a.
蛋白主名 其他名称

general transcription factor 3C polypeptide 1

TF3C-alpha

GTF3C1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GTF3C1 Q12789 MAGEA4 Homo sapiens Q1RN33
Y2H Array
25416956
种属内
GTF3C1 Q12789 MAGEA4 Homo sapiens Q1RN33
Y2H Prey Pooling
25416956
种属内
GTF3C1 Q12789 GTF3C2 Homo sapiens Q8WUA4
Anti Tag CoIP
17409385
种属内
GTF3C1 Q12789 CMTM5 Homo sapiens Q96DZ9
Validated Y2H
25416956
种属内
GTF3C1 Q12789 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
种属内
GTF3C1 Q12789 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Cerebellofaciodental Syndrome

Cerebellar-Facial-Dental Syndrome

CFDS
Esophageal Atresia/Tracheoesophageal Fistula

Esophageal Atresia And/Or Tracheoesophageal Fistula

Tracheoesophageal Fistula With Or Without Esohageal Atresia

Esophageal Atresia / Tracheoesophageal Fistula

Ea/Tef

Esophageal Atresia With Tracheoesophageal Fistula

Esophageal Atresia With Or Without Tracheoesophageal Fistula
Bulbar Polio

Poliomyelitis, Bulbar

Bulbar Poliomyelitis
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1

Smard1

DSMA1

Sianrf

Dhmn6

Spinal Muscular Atrophy With Respiratory Distress 1

HMN6

Severe Infantile Axonal Neuropathy With Respiratory Failure

Autosomal Recessive Distal Spinal Muscular Atrophy 1

Diaphragmatic Spinal Muscular Atrophy

Spinal Muscular Atrophy With Respiratory Distress Type 1

Neuronopathy, Distal Hereditary Motor, Type Vi

Hmn Vi

Neuronopathy, Severe Infantile Axonal, With Respiratory Failure

Distal Spinal Muscular Atrophy 1

Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress

Distal Hereditary Motor Neuropathy Type 6

Distal-Hmn Type 6

Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1

Spinal Muscular Atrophy, Diaphragmatic

Distal Hereditary Motor Neuronopathy Type Vi

Distal Spinal Muscular Atrophy Type 1

Hmnvi

Spinal Muscular Atrophy With Respiratory Distress

Autosomal Recessive Distal Spinal Muscular Atrophy Type 1

Neuronopathy, Distal Hereditary Motor, 6

Dhmn Vi

Distal Hereditary Motor Neuropathy Type Vi

Severe Infantile Axonal Neuronopathy With Respiratory Failure

Spinal Muscular Atrophy Distal Autosomal Recessive 1

Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy

Autosomal Recessive Distal Spinal Muscular Atrophy
Breast Squamous Cell Carcinoma

Breast Primary Squamous Cell Carcinoma

Primary Squamous Cell Carcinoma Of Breast

Primary Squamous Cell Carcinoma Of The Breast

Scc Of Breast

Squamous Cell Carcinoma Of Breast

Squamous Cell Breast Carcinoma
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05906 GTF3C1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GTF3C1 MGD MGI:107887
Bos taurus GTF3C1 VGNC VGNC:29702
Rattus norvegicus GTF3C1 RGD RGD:621048
Felis catus GTF3C1 VGNC VGNC:67503
Canis familiaris GTF3C1 VGNC VGNC:41551
Macaca mulatta GTF3C1 VGNC VGNC:73316
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