2. Gene
  3. NDRG4 - NDRG family member 4 Gene

NDRG4 - NDRG family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NDRG 家族成员 4

种属: Homo sapiens

同用名: BDM1; SMAP8; SMAP-8

基因 ID: 65009 | 基因类型: protein coding

关于 NDRG4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,463,715-58,515,387 (from NCBI)

This gene has 55 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 109.2), heart (RPKM 62.3) and 4 other tissues.

功能概要

该基因是属于 α/β 水解酶超家族的 N-myc 下调基因家族的成员。该基因编码的蛋白质是一种细胞质蛋白，是原代星形胶质细胞细胞周期进程和存活所必需的，并且可能参与调节血管平滑肌细胞中的促有丝分裂信号。选择性剪接导致多个转录本编码不同的异构体。[RefSeq 提供，2011 年 6 月]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

NDRG4 基因产物(24)

mRNA Protein Name
NM_001130487.2 NP_001123959.1 protein NDRG4 isoform 2
NM_001242833.2 NP_001229762.1 protein NDRG4 isoform 4
NM_001242834.2 NP_001229763.1 protein NDRG4 isoform 5
NM_001242835.2 NP_001229764.1 protein NDRG4 isoform 6
NM_001242836.2 NP_001229765.1 protein NDRG4 isoform 3
NM_001363869.2 NP_001350798.1 protein NDRG4 isoform 7
NM_001378332.1 NP_001365261.1 protein NDRG4 isoform 8
NM_001378333.1 NP_001365262.1 protein NDRG4 isoform 9
NM_001378334.1 NP_001365263.1 protein NDRG4 isoform 10
NM_001378335.1 NP_001365264.1 protein NDRG4 isoform 11
NM_001378336.1 NP_001365265.1 protein NDRG4 isoform 12
NM_001378337.1 NP_001365266.1 protein NDRG4 isoform 13
NM_001378338.1 NP_001365267.1 protein NDRG4 isoform 14
NM_001378339.1 NP_001365268.1 protein NDRG4 isoform 15
NM_001378340.1 NP_001365269.1 protein NDRG4 isoform 15
NM_001378341.1 NP_001365270.1 protein NDRG4 isoform 16
NM_001378342.1 NP_001365271.1 protein NDRG4 isoform 17
NM_001378343.1 NP_001365272.1 protein NDRG4 isoform 18
NM_001378344.1 NP_001365273.1 protein NDRG4 isoform 19
NM_001378345.1 NP_001365274.1 protein NDRG4 isoform 20
NM_001378346.1 NP_001365275.1 protein NDRG4 isoform 1
NM_001378347.1 NP_001365276.1 protein NDRG4 isoform 21
NM_020465.4 NP_065198.1 protein NDRG4 isoform 1
NM_022910.4 NP_075061.1 protein NDRG4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
12755708 GOA
involved in negative regulation of smooth muscle cell migration IDA
IDA: 通过直接分析推断
12755708 GOA
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
12755708 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
12755708 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
19535783 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12755708 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDRG4 蛋白结构

Ndr

Ndr: Ndr family (8 - 289)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
蛋白主名 其他名称

protein NDRG4

N-myc downstream-regulated gene 4 protein

NDRG4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NDRG4 Q9ULP0 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
种属内
NDRG4 Q9ULP0 RABAC1 Homo sapiens Q9UI14
Y2H Array
25416956
种属内
NDRG4 Q9ULP0 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
种属内
NDRG4 Q9ULP0 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
种属内
NDRG4 Q9ULP0 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Charcot-Marie-Tooth Disease, Type 4d

Charcot-Marie-Tooth Disease Type 4d

CMT4D

Hmsnl

Hmsn4d

Charcot-Marie-Tooth Neuropathy Type 4d

Hereditary Motor And Sensory Neuropathy Lom Type

Hmsn-Lom

Neuropathy, Hereditary Motor And Sensory, Lom Type

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d

Charcot-Marie-Tooth Neuropathy, Type 4d

Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d

Hmsn Lom Type

Hmsn, Lom Type

Hereditary Motor And Sensory Neuropathy, Lom Type

Charcot-Marie-Tooth Disease 4d

Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d

Hereditary Motor And Sensory Neuropathy Ivd

Hmsn Ivd
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis
Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09117 NDRG4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NDRG4 VGNC VGNC:31941
Macaca mulatta NDRG4 VGNC VGNC:74955
Canis familiaris NDRG4 VGNC VGNC:43681
Felis catus NDRG4 VGNC VGNC:63755
Mus musculus NDRG4 MGD MGI:2384590
Rattus norvegicus NDRG4 RGD RGD:621593
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