2. Gene
  3. PCTP - phosphatidylcholine transfer protein Gene

PCTP - phosphatidylcholine transfer protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酰胆碱转运蛋白

种属: Homo sapiens

同用名: PC-TP; STARD2

基因 ID: 58488 | 基因类型: protein coding

关于 PCTP

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,751,051-55,852,715 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 9.3), placenta (RPKM 5.2) and 24 other tissues.

功能概要

启用磷脂酰胆碱结合活性和磷脂酰胆碱转运蛋白活性。参与磷脂转运。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in phospholipid transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PCTP 基因产物(4)

mRNA Protein Name
NM_001102402.3 NP_001095872.1 phosphatidylcholine transfer protein isoform 2
NM_001330377.2 NP_001317306.1 phosphatidylcholine transfer protein isoform 3
NM_001330378.3 NP_001317307.1 phosphatidylcholine transfer protein isoform 4
NM_021213.4 NP_067036.2 phosphatidylcholine transfer protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylcholine binding IDA
IDA: 通过直接分析推断
12055623 GOA
enables phosphatidylcholine transporter activity IDA
IDA: 通过直接分析推断
12055623 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phospholipid transport IDA
IDA: 通过直接分析推断
12055623 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCTP 蛋白结构

START

START: START domain (14 - 211)

  • 0
  • 100
  • 200
  • 214 a.a.
蛋白主名 其他名称

phosphatidylcholine transfer protein

START domain-containing protein 2

PCTP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PCTP Q9UKL6 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
种属内
PCTP Q9UKL6 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153754 Phosphatidylcholine transfer protein inhibitor-1 98.01% 否
HY-110260 LDN-193188 / 否
HY-RS10178 PCTP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCTP RGD RGD:3276
Canis familiaris PCTP VGNC VGNC:44326
Mus musculus PCTP MGD MGI:107375
Macaca mulatta PCTP VGNC VGNC:75789
Felis catus PCTP VGNC VGNC:68738
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