1. Gene
  2. ACSF2 - acyl-CoA synthetase family member 2 Gene

ACSF2 - acyl-CoA synthetase family member 2 Gene

中文名称:酰基辅酶 A 合成酶家族成员 2

种属: Homo sapiens

同用名: ACSMW; AVYV493

基因 ID: 80221 | 基因类型: protein coding

关于 ACSF2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,426,218-50,474,845 (from NCBI)

This gene has 25 transcripts (splice variants), 256 orthologues and 13 paralogues. Broad expression in kidney (RPKM 73.1), thyroid (RPKM 24.6) and 18 other tissues.

功能概要

启用中链脂肪酸-CoA 连接酶活性。预测参与脂肪酸代谢过程。预测位于线粒体基质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables medium-chain fatty acid-CoA Ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ACSF2 基因产物(6)

mRNA Protein Name
NM_001288968.2 NP_001275897.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 1
NM_001288969.2 NP_001275898.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 3
NM_001288970.2 NP_001275899.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 4
NM_001288971.2 NP_001275900.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5
NM_001288972.2 NP_001275901.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5
NM_025149.6 NP_079425.3 medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables medium-chain fatty acid-CoA ligase activity IDA
IDA: 通过直接分析推断
17762044 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ACSF2 蛋白结构

AMP-binding

AMP-binding: AMP-binding enzyme (79 - 515)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (524 - 599)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 615 a.a.
蛋白主名 其他名称

medium-chain acyl-CoA ligase ACSF2, mitochondrial

PPARG binding, long chain fatty acid acyl Co-A ligase like

ACSF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ACSF2 Q96CM8 MICOS13 Homo sapiens Q5XKP0
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 MICOS13 Homo sapiens Q5XKP0
Y2H Array
32296183
种属内
ACSF2 Q96CM8 SYNGR3 Homo sapiens O43761
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 SYNGR3 Homo sapiens O43761
Y2H Array
32296183
种属内
ACSF2 Q96CM8 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
种属内
ACSF2 Q96CM8 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
种属内
ACSF2 Q96CM8 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
种属内
ACSF2 Q96CM8 RDH10 Homo sapiens Q8IZV5
Y2H Array
32296183
种属内
ACSF2 Q96CM8 RDH10 Homo sapiens Q8IZV5
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 APOC1 Homo sapiens P02654
Y2H Array
32296183
种属内
ACSF2 Q96CM8 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
种属内
ACSF2 Q96CM8 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
ACSF2 Q96CM8 C10orf67 Homo sapiens Q8IYJ2-2
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 C10orf67 Homo sapiens Q8IYJ2-2
Y2H Array
32296183
种属内
ACSF2 Q96CM8 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
种属内
ACSF2 Q96CM8 SIGLEC12 Homo sapiens Q96PQ1
Validated Y2H
32296183
种属内
ACSF2 Q96CM8 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
种属内
ACSF2 Q96CM8 CMTM5 Homo sapiens Q96DZ9
Y2H
21516116
种属内
ACSF2 Q96CM8 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
种属内
ACSF2 Q96CM8 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 APOA5 Homo sapiens Q6Q788
Y2H Array
32296183
种属内
ACSF2 Q96CM8 APOA5 Homo sapiens Q6Q788
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
种属内
ACSF2 Q96CM8 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
种属内
ACSF2 Q96CM8 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
种属内
ACSF2 Q96CM8 COQ9 Homo sapiens O75208
Y2H Array
32296183
种属内
ACSF2 Q96CM8 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
种属内
ACSF2 Q96CM8 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
种属内
ACSF2 Q96CM8 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus ACSF2 VGNC VGNC:25562
Felis catus ACSF2 VGNC VGNC:59532
Macaca mulatta ACSF2 VGNC VGNC:69536
Mus musculus ACSF2 MGD MGI:2388287
Canis familiaris ACSF2 VGNC VGNC:37530
Rattus norvegicus ACSF2 RGD RGD:1562656