1. Gene
  2. APOC1 - apolipoprotein C1 Gene

APOC1 - apolipoprotein C1 Gene

中文名称:载脂蛋白 C1

种属: Homo sapiens

同用名: Apo-CI; ApoC-I; apo-CIB; apoC-IB

基因 ID: 341 | 基因类型: protein coding

关于 APOC1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,914,325-44,919,346 (from NCBI)

This gene has 9 transcripts (splice variants) and 58 orthologues. Biased expression in liver (RPKM 1936.2) and adrenal (RPKM 201.2).

功能概要

该基因编码载脂蛋白 C1 家族的一个成员。该基因主要在肝脏中表达,并在单核细胞分化为巨噬细胞时被激活。编码的蛋白质在高密度脂蛋白 (HDL) 和极低密度脂蛋白 (VLDL) 代谢中起着核心作用。这种蛋白质也被证明可以抑制血浆中的胆固醇酯转移蛋白。该基因的假基因位于同一染色体下游 4 kb 处,方向相同。该基因被映射到 19 号染色体,位于载脂蛋白基因簇内。可变剪接和替代启动子的使用会导致多种转录本变体。[RefSeq 提供,2016 年 9 月]

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

APOC1 基因产物(8)

mRNA Protein Name
NM_001321066.2 NP_001307995.1 apolipoprotein C-I isoform a precursor
NM_001379687.1 NP_001366616.1 apolipoprotein C-I isoform b precursor
NM_001645.5 NP_001636.1 apolipoprotein C-I isoform a precursor
NM_001321065.2 NP_001307994.1 apolipoprotein C-I isoform a precursor
NM_001321065.2 NP_001307994.1 apolipoprotein C-I isoform a precursor
NM_001321066.2 NP_001307995.1 apolipoprotein C-I isoform a precursor
NM_001379687.1 NP_001366616.1 apolipoprotein C-I isoform b precursor
NM_001645.5 NP_001636.1 apolipoprotein C-I isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acid binding IDA
IDA: 通过直接分析推断
17339654 GOA
enables lipase inhibitor activity IDA
IDA: 通过直接分析推断
182536 GOA
enables phospholipase inhibitor activity IDA
IDA: 通过直接分析推断
2302419 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of high-density lipoprotein particle IDA
IDA: 通过直接分析推断
15576844 GOA
part of very-low-density lipoprotein particle IDA
IDA: 通过直接分析推断
15576844 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

APOC1 蛋白结构

ApoC-I

ApoC-I: pfam04691 (26 - 82)

  • 0
  • 83 a.a.
蛋白主名 其他名称

apolipoprotein C-I

APOC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra APOC1 P02654 RTP5 Homo sapiens Q14D33
Validated Y2H
32296183
Intra APOC1 P02654 SYT16 Homo sapiens Q17RD7
Validated Y2H
32296183
Intra APOC1 P02654 TEX44 Homo sapiens Q53QW1
Validated Y2H
32296183
Intra APOC1 P02654 H4C7 Homo sapiens Q99525
Validated Y2H
32296183
Intra APOC1 P02654 MAIP1 Homo sapiens Q8WWC4
Validated Y2H
32296183
Intra APOC1 P02654 MICOS13 Homo sapiens Q5XKP0
Validated Y2H
32296183
Intra APOC1 P02654 GSDMA Homo sapiens Q96QA5
Validated Y2H
32296183
Intra APOC1 P02654 FOXD4L3 Homo sapiens Q6VB84
Validated Y2H
32296183
Intra APOC1 P02654 ACACA Homo sapiens Q13085-4
Validated Y2H
32296183
Intra APOC1 P02654 RSAD2 Homo sapiens Q8WXG1
Validated Y2H
32296183
Intra APOC1 P02654 LETMD1 Homo sapiens Q6P1Q0
Validated Y2H
32296183
Intra APOC1 P02654 TPRG1 Homo sapiens Q6ZUI0
Validated Y2H
32296183
Intra APOC1 P02654 MP68 Homo sapiens P56378-2
Validated Y2H
32296183
Intra APOC1 P02654 ACSF2 Homo sapiens Q96CM8
Validated Y2H
32296183
Intra APOC1 P02654 DHRSX Homo sapiens Q8N5I4
Validated Y2H
32296183
Intra APOC1 P02654 MTCH2 Homo sapiens Q9Y6C9
Validated Y2H
32296183
Intra APOC1 P02654 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra APOC1 P02654 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra APOC1 P02654 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra APOC1 P02654 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra APOC1 P02654 RADIL Homo sapiens Q96JH8
Validated Y2H
32296183
Intra APOC1 P02654 MTERF3 Homo sapiens Q96E29
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Ovarian Cyst
Adermatoglyphia

ADERM

Immigration Delay Disease

Absence Of Fingerprints

Adg

Congenital Absence Of Fingerprints

Isolated Congenital Adermatoglyphia

Fingerprints, Absence Of

Skin Abnormalities

Aphasia
Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus APOC1 RGD RGD:2134
Macaca mulatta APOC1 VGNC VGNC:103787
Mus musculus APOC1 MGD MGI:88053
Canis familiaris APOC1 VGNC VGNC:37999