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  3. GSDMA - gasdermin A Gene

GSDMA - gasdermin A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：gasdermin A

种属: Homo sapiens

同用名: GSDM; FKSG9; GSDM1

基因 ID: 284110 | 基因类型: protein coding

关于 GSDMA

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,963,004-39,977,768 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 4 paralogues. Biased expression in skin (RPKM 16.4) and esophagus (RPKM 1.0).

功能概要

预测具有磷脂酰肌醇-4,5-二磷酸结合活性；磷脂酰肌醇-4-磷酸结合活性；和磷脂酰丝氨酸结合活性。参与细胞凋亡过程。位于细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GSDMA 基因产物(1)

mRNA Protein Name
NM_178171.5 NP_835465.2 gasdermin-A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables wide pore channel activity IDA
IDA: 通过直接分析推断
35110732 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
35110732 GOA
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
35110732 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in membrane IDA
IDA: 通过直接分析推断
35110732 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17471240 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSDMA 蛋白结构

Gasdermin

Gasdermin: Gasdermin family (3 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
蛋白主名 其他名称

gasdermin-A

gasdermin-1

GSDMA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GSDMA Q96QA5 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra GSDMA Q96QA5 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra GSDMA Q96QA5 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra GSDMA Q96QA5 APOC4 Homo sapiens P55056
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 22

IBD22
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05854 GSDMA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GSDMA RGD RGD:1592062
Felis catus GSDMA VGNC VGNC:62725
Macaca mulatta GSDMA VGNC VGNC:104606
Bos taurus GSDMA VGNC VGNC:49998
Canis familiaris GSDMA VGNC VGNC:54951
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